2025
Intravenous infusion of mesenchymal stem cells increased axonal signal intensity in the rubrospinal tract in spinal cord injury
Hirota R, Sasaki M, Teramoto A, Yamashita T, Kocsis J, Honmou O. Intravenous infusion of mesenchymal stem cells increased axonal signal intensity in the rubrospinal tract in spinal cord injury. Molecular Brain 2025, 18: 35. PMID: 40241097, PMCID: PMC12004759, DOI: 10.1186/s13041-025-01210-0.Peer-Reviewed Original ResearchConceptsIntravenous infusion of mesenchymal stem cellsInfusion of mesenchymal stem cellsSpinal cord injuryIntravenous infusionMesenchymal stem cellsRubrospinal tractCircuit reorganizationInfused mesenchymal stem cellsCord injuryNeural circuit reorganizationNeuronal tracing techniquesSignal intensityInjury siteFunctional improvementSpontaneous recoveryStem cellsDescending tractsAxonal connectionsInjuryAxonal growthTractAxonal network
2016
Reorganization of Intact Descending Motor Circuits to Replace Lost Connections After Injury
Fink KL, Cafferty WB. Reorganization of Intact Descending Motor Circuits to Replace Lost Connections After Injury. Neurotherapeutics 2016, 13: 370-381. PMID: 26846379, PMCID: PMC4824020, DOI: 10.1007/s13311-016-0422-x.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCentral nervous systemMotor pathwaysFunctional recoveryMotor functionMotor circuitsIntact circuitsIncomplete spinal cord injuryPartial spinal cord injuryAdult central nervous systemCorticospinal tract lesionsLimited spontaneous recoveryPermanent functional impairmentSpontaneous functional recoveryExperimental rodent modelsIntrinsic growth capacityRestoration of functionFine motor behaviorRaphespinal tractsDenervated sideTract lesionsCord injuryRubrospinal tractReticulospinal tractCNS neurons
2008
Nogo-66 Receptor Antagonist Peptide (NEP1-40) Administration Promotes Functional Recovery and Axonal Growth After Lateral Funiculus Injury in the Adult Rat
Cao Y, Shumsky JS, Sabol MA, Kushner RA, Strittmatter S, Hamers FP, Lee DH, Rabacchi SA, Murray M. Nogo-66 Receptor Antagonist Peptide (NEP1-40) Administration Promotes Functional Recovery and Axonal Growth After Lateral Funiculus Injury in the Adult Rat. Neurorehabilitation And Neural Repair 2008, 22: 262-278. PMID: 18056009, PMCID: PMC2853251, DOI: 10.1177/1545968307308550.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalDenervationEfferent PathwaysFemaleGPI-Linked ProteinsGrowth ConesMyelin ProteinsNerve RegenerationNeuronal PlasticityNogo Receptor 1Peptide FragmentsPyramidal TractsRaphe NucleiRatsRats, Sprague-DawleyReceptors, Cell SurfaceRecovery of FunctionRed NucleusSpinal Cord InjuriesSpinal Nerve RootsTreatment OutcomeWallerian DegenerationConceptsNEP1-40 groupDorsal root axonsRST axonsRubrospinal axonsRubrospinal tractAxonal growthNEP1-40 treatmentPromotes Functional RecoveryCervical spinal cordDorsal hemisectionForelimb usageNEP1-40Corticospinal axonsFunctional recoveryIntrathecal deliveryLateral funiculusSpinal cordMotor functionOutcome measuresAdult ratsLesion siteOperated controlsWhite matterGait analysisAxons
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