2024
There Is More to Life Than Walking: A Qualitative Study of Survivorship Among Peer Mentors in the Spinal Cord Injury Community
Kayani T, Cotter R, Sigworth J, Doolittle B. There Is More to Life Than Walking: A Qualitative Study of Survivorship Among Peer Mentors in the Spinal Cord Injury Community. The Yale Journal Of Biology And Medicine 2024, 97: 271-280. PMID: 39351326, PMCID: PMC11426298, DOI: 10.59249/yxeb6783.Peer-Reviewed Original ResearchConceptsPeer mentorship programSpinal cord injuryMentorship programSurvivorship journeySpinal cord injury survivorsPeer mentoringSpinal cord injury communityPost-injuryPost-injury rehabilitationPromote independent livingSemi-structured interviewsCommunity integrationStudies of survivorshipThematic analysisFamily supportQualitative studyEmotional copingIndependent livingTwenty-eight membersCord injuryLongitudinal effectsLife satisfactionAccessibility challengesSurvivorshipPost-SCI
2023
Cross-hemicord spinal fiber reorganization associates with cortical sensory and motor network expansion in the rat model of hemicontusion cervical spinal cord injury
Mihailovic J, Sanganahalli B, Hyder F, Chitturi J, Elkabes S, Heary R, Kannurpatti S. Cross-hemicord spinal fiber reorganization associates with cortical sensory and motor network expansion in the rat model of hemicontusion cervical spinal cord injury. Neuroscience Letters 2023, 820: 137607. PMID: 38141752, PMCID: PMC10797561, DOI: 10.1016/j.neulet.2023.137607.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCervical spinal cord injuryDiffusion tensor imagingCord injurySpinal cordCervical spinal cordState functional connectivitySpinal cord samplesSpinal cord diffusion tensor imagingMagnetic resonance imagingBrain functional MRIInjury epicenterSpinal reorganizationPost-SCINeuroplastic changesCord samplesCortical sensoryRat modelTraumatic injuryMD changeMotor networkNervous systemResonance imagingSingle-subject levelFunctional MRI
2020
Pericytes improve locomotor recovery after spinal cord injury in male and female neonatal rats
Mayo J, Kauer S, Brumley M, Bearden S. Pericytes improve locomotor recovery after spinal cord injury in male and female neonatal rats. Microcirculation 2020, 27: e12646. PMID: 32608116, DOI: 10.1111/micc.12646.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBlood Flow VelocityCell- and Tissue-Based TherapyCell ProliferationCell SurvivalCells, CulturedDisease Models, AnimalFemaleHeterograftsHindlimbHumansLocomotionMaleNeovascularization, PhysiologicPericytesRatsRecovery of FunctionSex FactorsSpinal CordSpinal Cord InjuriesConceptsSpinal cord injuryCord injuryVascular densityImproved motor function recoveryHindlimb motor recoveryMotor function recoveryFemale neonatal ratsRecovery post-SCIPostnatal day threeSite of injurySite of transectionBlood flow perfusionGreater vascular densityHypoxia-inducible factor (HIF) pathwayMotor recoveryLocomotor recoveryNeonatal modelPost-SCIFunction recoveryNew capillary growthNeonatal ratsAcute deliveryMotor functionSpinal cordRat pups
2015
Diffuse and persistent blood–spinal cord barrier disruption after contusive spinal cord injury rapidly recovers following intravenous infusion of bone marrow mesenchymal stem cells
Matsushita T, Lankford KL, Arroyo EJ, Sasaki M, Neyazi M, Radtke C, Kocsis JD. Diffuse and persistent blood–spinal cord barrier disruption after contusive spinal cord injury rapidly recovers following intravenous infusion of bone marrow mesenchymal stem cells. Experimental Neurology 2015, 267: 152-164. PMID: 25771801, DOI: 10.1016/j.expneurol.2015.03.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceBlood-Brain BarrierCell- and Tissue-Based TherapyDisease Models, AnimalEndothelial CellsExploratory BehaviorGlial Fibrillary Acidic ProteinLocomotionMaleMesenchymal Stem CellsMicrovesselsPermeabilityRatsRats, Sprague-DawleyRats, TransgenicReceptor, Platelet-Derived Growth Factor betaSpinal Cord InjuriesTime Factorsvon Willebrand FactorConceptsSpinal cord injuryContusive spinal cord injuryBlood-spinal cord barrierBSCB leakageIntravenous infusionMesenchymal stem cellsVon Willebrand factorMSC infusionCord injurySpinal cordBlood-spinal cord barrier disruptionExperimental spinal cord injuryIntravenous MSC infusionSpinal cord barrierEx vivo optical imagingDissociation of pericytesBone marrow mesenchymal stem cellsStem cellsMarrow mesenchymal stem cellsBSCB integrityBSCB permeabilityLocomotor recoveryPost-SCIBarrier disruptionAntigen expression
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