2025
Transcriptomic Alterations Induced by Tetrahydrocannabinol in SIV/HIV Infection: A Systematic Review
Valizadeh A, Veenhuis R, Bradley B, Xu K. Transcriptomic Alterations Induced by Tetrahydrocannabinol in SIV/HIV Infection: A Systematic Review. International Journal Of Molecular Sciences 2025, 26: 2598. PMID: 40141240, PMCID: PMC11942185, DOI: 10.3390/ijms26062598.Peer-Reviewed Original ResearchConceptsSimian immunodeficiency virus (SIV)-infected macaquesPrevalence of cannabis useSIV-infected macaquesChronic immune activationHIV-infected human cellsEpithelial cell proliferationModulate immune responsesSystematic reviewSIV/HIV infectionHIV infectionPreclinical evidencePathways related to inflammationImmune activationCannabis useMicro-RNA expressionImmunomodulatory roleImmunomodulatory effectsReduce inflammationImmune responseTetrahydrocannabinolComprehensive searchCell proliferationTranscriptomic alterationsMethodological qualityPWH
2024
Mesenchymal Stem Cells and Their Extracellular Vesicles: Therapeutic Mechanisms for Blood–Spinal Cord Barrier Repair Following Spinal Cord Injury
Nakazaki M, Yokoyama T, Lankford K, Hirota R, Kocsis J, Honmou O. Mesenchymal Stem Cells and Their Extracellular Vesicles: Therapeutic Mechanisms for Blood–Spinal Cord Barrier Repair Following Spinal Cord Injury. International Journal Of Molecular Sciences 2024, 25: 13460. PMID: 39769223, PMCID: PMC11677717, DOI: 10.3390/ijms252413460.Peer-Reviewed Original ResearchConceptsBlood-spinal cord barrierBSCB repairMesenchymal stromal/stem cellsSpinal cord injuryMSC-EVsMesenchymal stromal/stem cell therapyBlood-spinal cord barrier integritySpinal cord homeostasisBlood-spinal cord barrier permeabilityCord injuryImpaired axonal regenerationTreating spinal cord injuryCell-free alternativeExtracellular vesiclesTight junction proteinsSpinal neural tissueBlood-brain barrierImprove patient outcomesAnti-inflammatory propertiesImmune cellsPreclinical studiesJunction proteinsSecreted extracellular vesiclesClinical trialsReduce inflammationPlatelet–Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease
Zhang Y, Jia C, Guo M, Chen Q, Wen Y, Wang T, Xie Y, Fan X, Gao J, Yarovinsky T, Liu R, Jiang Z, Wang M, Zhou J, Che D, Fu L, Edelson R, Gu X, Hwa J, Tang W. Platelet–Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease. Advanced Science 2024, 12: 2406282. PMID: 39665236, PMCID: PMC11792051, DOI: 10.1002/advs.202406282.Peer-Reviewed Original ResearchKawasaki diseaseCD14<sup>+</sup>CD16<sup>+</sup> monocytesPlatelet-monocyte aggregatesAberrant immune responseAcute febrile illnessCoronary artery aneurysmsNuclear factor-kappaBSystemic vasculitisPlatelet-monocyteProinflammatory monocytesPlatelet hyperreactivityArtery aneurysmVasculopathyFebrile illnessCytokine mediatorsHyperactive plateletsReduce inflammationPlatelet glycoproteinImmune responseInterleukin-1Platelet activationPositive feedback loopLigand 1MonocytesGrowth factorStrategically Staged Tumor Ablation and Inflammation Suppression Using Shell‐Core Nanoparticles to Eradicate Bladder Tumors and Prevent Recurrence
Xu Y, Zhang R, Zhu J, Guo Z, Jin D, Qian L, Yang Y, Chen H. Strategically Staged Tumor Ablation and Inflammation Suppression Using Shell‐Core Nanoparticles to Eradicate Bladder Tumors and Prevent Recurrence. Advanced Functional Materials 2024, 34 DOI: 10.1002/adfm.202402078.Peer-Reviewed Original ResearchPrevent tumor recurrenceBladder tumorsTumor recurrenceTumor ablationPreventing bladder tumor recurrenceRat bladder tumor modelBladder tumor modelBladder tumor recurrenceInflammation suppressionCancer-related inflammationRelease of nitric oxideAnti-inflammatory effectsAcidic tumor environmentTumor environmentTumor modelPrevent recurrenceReduce inflammationTumorRecurrenceInflammationReactive oxygen speciesNitric oxideIn vitroAbstract NanomedicineAnti-tumorNovel muscle-derived extracellular matrix hydrogel promotes angiogenesis and neurogenesis in volumetric muscle loss
Chen Z, Huang Y, Xing H, Tseng T, Edelman H, Perry R, Kyriakides T. Novel muscle-derived extracellular matrix hydrogel promotes angiogenesis and neurogenesis in volumetric muscle loss. Matrix Biology 2024, 127: 38-47. PMID: 38325441, PMCID: PMC10958762, DOI: 10.1016/j.matbio.2024.02.001.Peer-Reviewed Original ResearchConceptsDecellularized extracellular matrixVolumetric muscle lossCharacterization of hydrogelsExtracellular matrix hydrogelTreat VML injuriesMuscle lossEnhancement of tissue repairRegenerative capacity of skeletal muscleMatrix hydrogelPromote muscle repairRegenerative capacityHydrogelsVolumetric muscle loss modelNative biomaterialsScar tissue formationEnhanced cell invasionCapacity of skeletal muscleMuscle repairTibialis anterior muscleClinical challengeBlood vessel formationReduce inflammationVML injuryLoss of functionSubcutaneous implantation
2023
The role of local inflammation in complications associated with intubation in pediatric patients: A narrative review
Amaya S, Murillo M, Pérez M, Cervera H, Andrade M, Zuñiga M, Barreto N, Daza M, Carvajal L, Alarcón C, Aponte L, Olbrecht V. The role of local inflammation in complications associated with intubation in pediatric patients: A narrative review. Pediatric Anesthesia 2023, 33: 427-434. PMID: 36719267, DOI: 10.1111/pan.14643.Peer-Reviewed Original ResearchConceptsPediatric patientsOrotracheal intubationAssociated with worse outcomesComplications associated with intubationOral bacterial floraAdvanced airway managementIntubated pediatric patientsNarrative reviewProlonged intubationTreatment optionsWorse outcomesLocal inflammationAirway managementPatient populationExperience complicationsInflammatory mediatorsReduce inflammationInflammatory responseIntubationPatientsComplicationsPresence of traumaInflammationExcessive manipulationBacterial flora
2019
Keratinocyte-derived CCL20 orchestrates epidermal localization of IL-17-producing γδ T cells and ILCs to mediate psoriasis-like skin inflammation
Singh T, Lu X, Singh S, Zhang H, Doucet M, Kominsky S, Farber J. Keratinocyte-derived CCL20 orchestrates epidermal localization of IL-17-producing γδ T cells and ILCs to mediate psoriasis-like skin inflammation. The Journal Of Immunology 2019, 202: 183.21-183.21. DOI: 10.4049/jimmunol.202.supp.183.21.Peer-Reviewed Original ResearchIL-17-producingT cellsKnock-In MiceIL-17Psoriasis-like skin inflammationGd T cellsExpression of CCL20Expression of IL17Hair folliclesCCR6 ligandIMQ treatmentPsoriatic dermatitisCCR6IL-22Skin inflammationReduce inflammationCCL20Day 4Treated skinInflammationMiceB-defensinsSuperficial epidermisKeratinocytesIMQ
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