2025
The United Kingdom Hand and Upper Limb Transplantation Service: A report on the first twelve years of a single-center, single-protocol clinical cohort
Leonard D, Natalwala I, Taplin S, Burdon J, Clarke E, Seitz A, Merchant W, Wilks D, Clark B, Bellew M, Baker R, Bourke G, Kay S. The United Kingdom Hand and Upper Limb Transplantation Service: A report on the first twelve years of a single-center, single-protocol clinical cohort. Journal Of Plastic Reconstructive & Aesthetic Surgery 2025, 106: 331-341. PMID: 40472654, DOI: 10.1016/j.bjps.2025.05.001.Peer-Reviewed Original ResearchConceptsDonor-specific antibodiesFollow-upSingle-centerYears of follow-upSemmes-Weinstein monofilament testBox & Block TestHistory of dialysisLevel of amputationComposite functional scoresPatient satisfaction questionnaireWorld's first caseFunctional outcome measuresUpper limb transplantationMycophenolate mofetilRenal impairmentClinically significant improvementPsychological follow-upImmunosuppression monitoringGraft survivalRejection monitoringSecondary surgeryImmunological evaluationSurgical techniqueMonofilament testSF-36B-cell infiltration distinguishes mucosal from skin patterns of rejection in facial vascularized composite allografts
Kauke-Navarro M, Crisler W, Younis N, Khetani R, Sadigh S, Teague J, Ho Sui S, Ko C, Zhan Q, Steuart S, Treister N, Pober J, Azzi J, Clark R, Pomahac B. B-cell infiltration distinguishes mucosal from skin patterns of rejection in facial vascularized composite allografts. American Journal Of Transplantation 2025, 25: 1193-1207. PMID: 39842779, DOI: 10.1016/j.ajt.2025.01.013.Peer-Reviewed Original ResearchFacial Vascularized Composite AllotransplantationPeripheral blood mononuclear cellsB cell infiltrationB cellsMucosal rejectionRejection monitoringFacial vascularized composite allograftT cell-mediated rejectionSigns of immune activationNon-rejection biopsiesGranzyme B expressionB cell populationsInnate-like B cellsBlood mononuclear cellsVascularized Composite AllograftsVascularized Composite AllotransplantationAcute rejectionOral mucosaT cellsPattern of rejectionImmune activationMucosal biopsiesPlasma cellsSkin biopsiesMononuclear cells
2024
Outcome-based Risk Assessment of Non-HLA Antibodies in Heart Transplantation: A Systematic Review
Panicker A, Prokop L, Hacke K, Jaramillo A, Griffiths L. Outcome-based Risk Assessment of Non-HLA Antibodies in Heart Transplantation: A Systematic Review. The Journal Of Heart And Lung Transplantation 2024, 43: 1450-1467. PMID: 38796046, DOI: 10.1016/j.healun.2024.05.012.Peer-Reviewed Original ResearchConceptsNon-HLA antibodiesEndomyocardial biopsyHeart transplantationRejection pathologyDonor-specific anti-human leukocyte antigen antibodiesAnti-human leukocyte antigen antibodiesHistocompatibility complex class I chain-related gene ANon-human leukocyte antigenSystematic reviewNon-HLA antigensStrength of evidenceAntibody-mediated rejectionInvasive endomyocardial biopsyPositive endomyocardial biopsyClinical risk stratificationHLA-DSAHT recipientsRejection monitoringLeukocyte antigenRisk stratificationRejection eventsRisk factorsInclusion criteriaAntigen antibodiesAntibodies
2015
Utility of Sentinel Flaps in Assessing Facial Allograft Rejection
Kueckelhaus M, Fischer S, Lian C, Bueno E, Marty F, Tullius S, Pribaz J, Murphy G, Pomahac B. Utility of Sentinel Flaps in Assessing Facial Allograft Rejection. Plastic & Reconstructive Surgery 2015, 135: 250-258. PMID: 25255116, DOI: 10.1097/prs.0000000000000797.Peer-Reviewed Original ResearchConceptsFacial allograftRejection monitoringFasciocutaneous radial forearm flapCLINICAL QUESTION/LEVELSevere rejection episodesFurther surgical proceduresFacial allotransplantationFree fasciocutaneous radial forearm flapRadial forearm flapAxial blood supplyFunctional flapNonfacial sitesRejection episodesLimited skin areaSevere rejectionAllograft rejectionClinical findingsFacial dermatitisFrequent biopsiesBiopsy pairsBiopsy specimensHistologic evaluationSkin biopsiesBlood supplySurgical procedures
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