2024
Analyzing determinants of premature trial discontinuation in leukemia clinical trials
Rotter L, Alhajahjeh A, Stempel J, Grimshaw A, Bewersdorf J, Blaha O, Kewan T, Podoltsev N, Shallis R, Mendez L, Stahl M, Zeidan A. Analyzing determinants of premature trial discontinuation in leukemia clinical trials. Leukemia & Lymphoma 2024, 66: 289-297. PMID: 39440622, DOI: 10.1080/10428194.2024.2416565.Peer-Reviewed Original ResearchClinical trialsSlow accrualLeukemia trialsEarly-phase trialsNon-randomized trialsAcademic-sponsored trialsImprove patient outcomesLeukemia clinical trialsSingle-centerTrial discontinuationSponsored trialsSmall trialsLeukemiaEarly terminationPatient outcomesLate-phaseIndependent reviewersTermination ratesComprehensive searchTrials
2021
JAK-inhibitor and type I interferon ability to produce favorable clinical outcomes in COVID-19 patients: a systematic review and meta-analysis
Walz L, Cohen AJ, Rebaza AP, Vanchieri J, Slade MD, Dela Cruz CS, Sharma L. JAK-inhibitor and type I interferon ability to produce favorable clinical outcomes in COVID-19 patients: a systematic review and meta-analysis. BMC Infectious Diseases 2021, 21: 47. PMID: 33430799, PMCID: PMC7797881, DOI: 10.1186/s12879-020-05730-z.Peer-Reviewed Original ResearchConceptsCOVID-19 patientsType I interferonOdds of mortalityPositive clinical outcomesClinical outcomesI interferonICU admissionExcessive cytokine releaseType I interferon treatmentStandard treatment groupOdds of dischargeFavorable clinical outcomeNon-randomized trialsJanus kinase inhibitorSearch of MEDLINETerms of mortalityKinase inhibitor treatmentHospital dischargeCytokine releaseInterferon treatmentPotential antiviral candidatesNovel therapiesTreatment outcomesTreatment groupsAntiviral candidates
2020
Feasibility Study of Back2School, a Modular Cognitive Behavioral Intervention for Youth With School Attendance Problems
Lomholt JJ, Johnsen DB, Silverman WK, Heyne D, Jeppesen P, Thastum M. Feasibility Study of Back2School, a Modular Cognitive Behavioral Intervention for Youth With School Attendance Problems. Frontiers In Psychology 2020, 11: 586. PMID: 32328012, PMCID: PMC7153503, DOI: 10.3389/fpsyg.2020.00586.Peer-Reviewed Original ResearchCognitive-behavioral interventionsModular cognitive behavioral interventionBehavioral interventionsEvidence-based modulesNon-randomized trialsTransdiagnostic cognitive-behavioural interventionSignificant increaseSchool attendance dataEffectiveness trialSchool attendancePsychological symptomsFeasibility dataLevel of staffingStudy proceduresAarhus MunicipalityTrialsSchool attendance problemsTreatment deliveryIntervention outcomesInterventionSession twoSchool registersBehavior problemsConsultationCurrent study
2016
Endoscopic balloon dilation in the management of strictures in Crohn’s disease: a systematic review and meta-analysis of non-randomized trials
Navaneethan U, Lourdusamy V, Njei B, Shen B. Endoscopic balloon dilation in the management of strictures in Crohn’s disease: a systematic review and meta-analysis of non-randomized trials. Surgical Endoscopy 2016, 30: 5434-5443. PMID: 27126619, DOI: 10.1007/s00464-016-4902-1.Peer-Reviewed Original ResearchConceptsEndoscopic balloon dilationSurgical intervention rateRisk of surgical interventionManagement of Crohn’s stricturesIntervention ratesPrimary stricturesCrohn's stricturesBalloon dilationSurgical interventionAdverse eventsMethodsA comprehensive search of MEDLINEDecreased riskTreated with endoscopic balloon dilationMedian follow-up periodDilatation of anastomotic stricturesSafety of endoscopic balloon dilationAssociated with strictureComprehensive search of MEDLINEFollow-up periodDiagnosis of CDMethodsA comprehensive searchNon-randomized trialsSystematic reviewManagement of stricturesPrimary outcome measure
2013
Analysis of toxicity and outcomes in patients undergoing hyperthermic isolated hepatic perfusion with melphalan for metastatic melanoma to the liver.
Golas B, Magge D, Zureikat A, Zeh H, Alexander H, Libutti S, Royal R, Hughes M, Holtzman M, Turaga K, Pappas S, Gamblin T, Bartlett D, Pingpank J. Analysis of toxicity and outcomes in patients undergoing hyperthermic isolated hepatic perfusion with melphalan for metastatic melanoma to the liver. Journal Of Clinical Oncology 2013, 31: 178-178. DOI: 10.1200/jco.2013.31.4_suppl.178.Peer-Reviewed Original ResearchLiver metastasesOcular melanomaUnresectable LMOverall survivalHepatic tumor burdenHigh-dose melphalanLiver-directed therapiesRetrohepatic vena cavaNon-randomized trialsPatients per yearMedian OSOS probabilityProgression-FreeProlonged OSRadiographic responseMedian survivalTumor burdenMetastatic melanomaTumor regressionWHO criteriaVena cavaHepatic perfusionKaplan-MeierTreated patientsGastroduodenal artery
2012
Sanitary Pad Interventions for Girls' Education in Ghana: A Pilot Study
Montgomery P, Ryus CR, Dolan CS, Dopson S, Scott LM. Sanitary Pad Interventions for Girls' Education in Ghana: A Pilot Study. PLOS ONE 2012, 7: e48274. PMID: 23118968, PMCID: PMC3485220, DOI: 10.1371/journal.pone.0048274.Peer-Reviewed Original ResearchConceptsPuberty educationGirls' educationSchool attendanceEducation of girlsSecondary educationEducationDevelopment needsAttendance levelsEducation interventionEvents of menarcheGirls transitionSanitary padsAttendancePilot studyPan African Clinical Trials RegistryAfrican Clinical Trials RegistryPAD interventionsClinical Trials RegistryNon-randomized trialsContextPositive healthProvisionGhanaSchoolgirlsParticipants
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