2024
Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort
Barr P, Bigdeli T, Meyers J, Peterson R, Sanchez-Roige S, Mallard T, Dick D, Harden K, Wilkinson A, Graham D, Nielsen D, Swann A, Lipsky R, Kosten T, Aslan M, Harvey P, Kimbrel N, Beckham J, Aslan M, Antonelli M, de Asis M, Bauer M, Brophy M, Concato J, Cunningham F, Freedman R, Gaziano M, Gleason T, Harvey P, Huang G, Kelsoe J, Kosten T, Lehner T, Lohr J, Marder S, Miller P, O Leary T, Patterson T, Peduzzi P, Przygodski R, Siever L, Sklar P, Strakowski S, Zhao H, Fanous A, Farwell W, Malhorta A, Mane S, Palacios P, Bigdeli T, Corsey M, Zaluda L, Johnson J, Sueiro M, Cavaliere D, Jeanpaul V, Maffucci A, Mancini L, Deen J, Muldoon G, Whitbourne S, Canive J, Adamson L, Calais L, Fuldauer G, Kushner R, Toney G, Lackey M, Mank A, Mahdavi N, Villarreal G, Muly E, Amin F, Dent M, Wold J, Fischer B, Elliott A, Felix C, Gill G, Parker P, Logan C, McAlpine J, DeLisi L, Reece S, Hammer M, Agbor-Tabie D, Goodson W, Aslam M, Grainger M, Richtand N, Rybalsky A, Al Jurdi R, Boeckman E, Natividad T, Smith D, Stewart M, Torres S, Zhao Z, Mayeda A, Green A, Hofstetter J, Ngombu S, Scott M, Strasburger A, Sumner J, Paschall G, Mucciarelli J, Owen R, Theus S, Tompkins D, Potkin S, Reist C, Novin M, Khalaghizadeh S, Douyon R, Kumar N, Martinez B, Sponheim S, Bender T, Lucas H, Lyon A, Marggraf M, Sorensen L, Surerus C, Sison C, Amato J, Johnson D, Pagan-Howard N, Adler L, Alerpin S, Leon T, Mattocks K, Araeva N, Sullivan J, Suppes T, Bratcher K, Drag L, Fischer E, Fujitani L, Gill S, Grimm D, Hoblyn J, Nguyen T, Nikolaev E, Shere L, Relova R, Vicencio A, Yip M, Hurford I, Acheampong S, Carfagno G, Haas G, Appelt C, Brown E, Chakraborty B, Kelly E, Klima G, Steinhauer S, Hurley R, Belle R, Eknoyan D, Johnson K, Lamotte J, Granholm E, Bradshaw K, Holden J, Jones R, Le T, Molina I, Peyton M, Ruiz I, Sally L, Tapp A, Devroy S, Jain V, Kilzieh N, Maus L, Miller K, Pope H, Wood A, Meyer E, Givens P, Hicks P, Justice S, McNair K, Pena J, Tharp D, Davis L, Ban M, Cheatum L, Darr P, Grayson W, Munford J, Whitfield B, Wilson E, Melnikoff S, Schwartz B, Tureson M, D Souza D, Forselius K, Ranganathan M, Rispoli L, Sather M, Colling C, Haakenson C, Kruegar D, Muralidhar S, Ramoni R, Breeling J, Chang K, O Donnell C, Tsao P, Moser J, Brewer J, Warren S, Argyres D, Stevens B, Humphries D, Do N, Shayan S, Nguyen X, Pyarajan S, Cho K, Hauser E, Sun Y, Wilson P, McArdle R, Dellitalia L, Harley J, Whittle J. Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort. JAMA Psychiatry 2024, 81: 188-197. PMID: 37938835, PMCID: PMC10633411, DOI: 10.1001/jamapsychiatry.2023.4141.Peer-Reviewed Original ResearchSubstance use disordersPolygenic risk scoresMillion Veteran ProgramCorrelates of riskElectronic health recordsPsychiatric problemsComorbid psychiatric problemsViral hepatitis C.Chronic airway obstructionHealth recordsElectronic health record dataUS veteran populationMillion Veteran Program cohortCommon etiologic pathwayHealth care centersHealth record dataInternational Statistical ClassificationSuicide-related behaviorsAirway obstructionCohort studyHepatitis C.Recent genome-wide association studiesLiver diseaseUS veteransCare centerIntegrating mental health into primary care in Nigeria: Implementation outcomes and clinical impact of the HAPPINESS intervention
Iheanacho T, Chu C, Aguocha C, Nwefoh E, Dike C. Integrating mental health into primary care in Nigeria: Implementation outcomes and clinical impact of the HAPPINESS intervention. Cambridge Prisms Global Mental Health 2024, 11: e9. PMID: 38390244, PMCID: PMC10882178, DOI: 10.1017/gmh.2024.4.Peer-Reviewed Original ResearchPost-interventionMental healthScale-up mental health servicesPatient Health Questionnaire scoresPrimary health care centersEffect sizeMental health servicesHealth care centersTechnology-supported interventionsStatistically significant reductionQuasi-experimental designPrimary careIntervention implementationImplementation outcomesHealth servicesHealth actionsCommunity-BasedBrief Psychiatric Rating Scale scoresQuestionnaire scoresSignificant reductionPsychiatric Rating Scale scoresCare centerPsychiatric problemsHappiness interventionsHealth
2023
Advancing diagnosis and management of liver disease in adults through exome sequencing
Zheng M, Hakim A, Konkwo C, Deaton A, Ward L, Genetics A, Silveira M, Assis D, Liapakis A, Jaffe A, Jiang Z, Curry M, Lai M, Cho M, Dykas D, Bale A, Mistry P, Vilarinho S. Advancing diagnosis and management of liver disease in adults through exome sequencing. EBioMedicine 2023, 95: 104747. PMID: 37566928, PMCID: PMC10433007, DOI: 10.1016/j.ebiom.2023.104747.Peer-Reviewed Original ResearchConceptsLiver diseaseWhole-exome sequencingUnknown etiologyTertiary referral academic medical centerReferral academic medical centerExome sequencingLiver disease patientsManagement of adultsAcademic health care centerComprehensive clinical evaluationHealth care centersAcademic medical centerGenetic variantsRare genetic variantsAdult patientsLiver centersHepatic steatosisDisease patientsClinical evaluationCare centerFamily historyMedical CenterClinical valueAdult medicinePatientsRetatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA
Rosenstock J, Frias J, Jastreboff A, Du Y, Lou J, Gurbuz S, Thomas M, Hartman M, Haupt A, Milicevic Z, Coskun T. Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA. The Lancet 2023, 402: 529-544. PMID: 37385280, DOI: 10.1016/s0140-6736(23)01053-x.Peer-Reviewed Original ResearchConceptsGlucose-dependent insulinotropic polypeptideType 2 diabetesGLP-1 receptor agonistsEscalation groupPhase 2 trialReceptor agonistDulaglutide groupPlacebo groupStudy treatmentGLP-1Interactive web response systemModerate gastrointestinal adverse eventsType 2 diabetes managementCurrent consensus guidelinesGastrointestinal adverse eventsWeb response systemPhase 1 studyStudy site personnelHealth care centersGlucagon receptor agonistPhase 3 programRange of dosesPhase 2 dataBaseline HbAGlycaemic targetsDevelopment of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis
Gunasekera K, Marcy O, Muñoz J, Lopez-Varela E, Sekadde M, Franke M, Bonnet M, Ahmed S, Amanullah F, Anwar A, Augusto O, Aurilio R, Banu S, Batool I, Brands A, Cain K, Carratalá-Castro L, Caws M, Click E, Cranmer L, García-Basteiro A, Hesseling A, Huynh J, Kabir S, Lecca L, Mandalakas A, Mavhunga F, Myint A, Myo K, Nampijja D, Nicol M, Orikiriza P, Palmer M, Sant'Anna C, Siddiqui S, Smith J, Song R, Thuong Thuong N, Ung V, van der Zalm M, Verkuijl S, Viney K, Walters E, Warren J, Zar H, Marais B, Graham S, Debray T, Cohen T, Seddon J. Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis. The Lancet Child & Adolescent Health 2023, 7: 336-346. PMID: 36924781, PMCID: PMC10127218, DOI: 10.1016/s2352-4642(23)00004-4.Peer-Reviewed Original ResearchConceptsTreatment decision algorithmsPrimary health care settingsIndividual participant dataHigh tuberculosis incidencePulmonary tuberculosisManagement of tuberculosisHealth care centersComposite reference standardHealth care settingsClinical featuresTuberculosis incidenceClinical evaluationParticipant dataTreatment decisionsChest X-ray featuresPrimary health care centersFuture prospective evaluationTuberculosis-related mortalityEvidence-based algorithmChest X-rayVariable diagnostic performanceMultivariable prediction modelReference standardEvidence-based approachTuberculosis experts
2022
Prevalence and Molecular Mechanisms of Carbapenem Resistance among Gram-Negative Bacilli in Three Hospitals of Northern Lebanon
Rima M, Oueslati S, Dabos L, Daaboul D, Mallat H, Raad E, Achkar M, Mawlawi O, Bernabeu S, Bonnin R, Girlich D, Osman M, Hamze M, Naas T. Prevalence and Molecular Mechanisms of Carbapenem Resistance among Gram-Negative Bacilli in Three Hospitals of Northern Lebanon. Antibiotics 2022, 11: 1295. PMID: 36289953, PMCID: PMC9598570, DOI: 10.3390/antibiotics11101295.Peer-Reviewed Original ResearchCarbapenem-resistant Gram-negative bacilliCarbapenem resistanceGram-negative bacilliHealth care centersCare centerEpidemiological surveyDiscordant resultsCarba NP testHealth issuesOXA-162PCR sequencingNP testHospitalPrevalenceMolecular mechanismsNovel variantsIsolatesImmunochromatographic assayRegistration systemResistance spreadOXABacilliCarbapenemsGenesImplementación de la Iniciativa HEARTS en Argentina: primeros resultados
Rodriguez G, Rosende A, Prado C, Mariño R, Irazola V, DiPette D, Orias M, Arcila G, Laspiur S. Implementación de la Iniciativa HEARTS en Argentina: primeros resultados. BULL PAN AM HEALTH ORGAN 2022, 46: e181. PMID: 36160765, PMCID: PMC9491484, DOI: 10.26633/rpsp.2022.181.Peer-Reviewed Original ResearchCombination therapyHearts InitiativePrimary health care centersStandardized treatment protocolMain risk factorsHealth care centersCause of mortalityBlood pressure measurement devicesArterial hypertensionRisk factorsCare centerTherapy levelsCardiovascular diseaseHealth centersTreatment protocolHealth teamsBaseline valuesParadoxical decreasePressure measurement deviceClinical competencyPeriod of restrictionHypertensionGeneralized reductionCOVID-19Therapy
2021
Fresh frozen plasma transfusion in acute variceal haemorrhage: Results from a multicentre cohort study
Mohanty A, Kapuria D, Canakis A, Lin H, Amat MJ, Paniz G, Placone NT, Thomasson R, Roy H, Chak E, Baffy G, Curry MP, Laine L, Rustagi T. Fresh frozen plasma transfusion in acute variceal haemorrhage: Results from a multicentre cohort study. Liver International 2021, 41: 1901-1908. PMID: 33969607, DOI: 10.1111/liv.14936.Peer-Reviewed Original ResearchConceptsAcute variceal hemorrhageFresh frozen plasma transfusionFrozen plasma transfusionFFP transfusionLength of stayPlasma transfusionVariceal hemorrhageCohort studyClinical outcomesEnd-stage liver disease (MELD) scoreStage liver disease scoreTertiary health care centerSevere variceal bleedingLiver Disease scoreMulticentre cohort studyRetrospective cohort studyHigh-risk patientsOdds of mortalityPoor clinical outcomeHealth care centersMultivariable regression analysisEligible patientsActive bleedingVariceal bleedingMultivariable analysis
2020
The short-term impact on economic outcomes of SBIRT interventions implemented in reproductive health care settings
Olmstead TA, Martino S, Ondersma SJ, Gilstad-Hayden K, Forray A, Yonkers KA. The short-term impact on economic outcomes of SBIRT interventions implemented in reproductive health care settings. Journal Of Substance Use And Addiction Treatment 2020, 120: 108179. PMID: 33298305, PMCID: PMC7733031, DOI: 10.1016/j.jsat.2020.108179.Peer-Reviewed Original ResearchConceptsReproductive health care settingsHealth care settingsGeneral health care utilizationHealth care utilizationCare settingsE-SBIRTCare utilizationReproductive health care centersRandomized clinical trialsHealth care centersPopulation of womenImpact of screeningMisused prescription medicationsMotor vehicle crashesPublic health perspectiveFuture systematic reviewsSBIRT interventionUsual careRoutine careSBIRT programEconomic outcomesPrescription medicationsCare centerClinical trialsDifferences regression modelsTrends Among Rural and Urban Medicare Beneficiaries in Care Delivery and Outcomes for Acute Stroke and Transient Ischemic Attacks, 2008-2017
Wilcock A, Zachrison K, Schwamm L, Uscher-Pines L, Zubizarreta J, Mehrotra A. Trends Among Rural and Urban Medicare Beneficiaries in Care Delivery and Outcomes for Acute Stroke and Transient Ischemic Attacks, 2008-2017. JAMA Neurology 2020, 77: 863-871. PMID: 32364573, PMCID: PMC7358912, DOI: 10.1001/jamaneurol.2020.0770.Peer-Reviewed Original ResearchConceptsTransient ischemic attackAcute ischemic strokeIschemic attackAcute strokeStroke centersRural-urban disparitiesResidential zip codeIschemic strokeEnd-stage kidney diseaseRural-Urban Commuting Area codesDescriptive observational studyHealth care centersUrban Medicare beneficiariesQuality of careTraditional MedicareNeurologist evaluationOutcome patientsUrban patientsStroke careNeurology consultationKidney diseaseMean ageCare centerStroke systemsObservational study
2019
Clinical utility of genomic analysis in adults with idiopathic liver disease
Hakim A, Zhang X, DeLisle A, Oral EA, Dykas D, Drzewiecki K, Assis DN, Silveira M, Batisti J, Jain D, Bale A, Mistry PK, Vilarinho S. Clinical utility of genomic analysis in adults with idiopathic liver disease. Journal Of Hepatology 2019, 70: 1214-1221. PMID: 31000363, PMCID: PMC6526061, DOI: 10.1016/j.jhep.2019.01.036.Peer-Reviewed Original ResearchConceptsIdiopathic liver diseaseUnexplained liver diseaseManagement of adultsWhole-exome sequencingLiver diseaseAdult patientsUnknown etiologyHeterozygous variantsUse of WESAmelioration of dyslipidemiaDaily insulin requirementLeptin replacement therapyUtility of WESChronic liver diseaseNon-alcoholic steatohepatitisAcademic health care centerHealth care centersHomozygous pathogenic variantUnrelated adult patientsNon-oncological diseasesDisease preventive measuresInsulin requirementsLean patientsDevastating complicationLiver aminotransferases
2017
Development of the Yale Gender Center: An Early Progress Report.
Olezeski CL, Boulware SD. Development of the Yale Gender Center: An Early Progress Report. Connecticut Medicine 2017, 81: 41-44. PMID: 29782766.Peer-Reviewed Original Research
2006
Decentralising tuberculosis case management in two districts of Burkina Faso.
Drabo K, Dauby C, Coste T, Dembelé M, Hien C, Ouedraogo A, Macq J, Ouedraogo J, Dujardin B. Decentralising tuberculosis case management in two districts of Burkina Faso. The International Journal Of Tuberculosis And Lung Disease 2006, 10: 93-8. PMID: 16466044.Peer-Reviewed Original ResearchConceptsNational Tuberculosis ProgrammeCase managementTB suspectsSmear-positive TB casesPrimary health care centersTuberculosis case managementTB case managementHealth care centersHealth care delivery systemCare delivery systemConfirmation of TBChronic coughTB casesTuberculosis ProgrammeDistrict hospitalCare centerDetection rateCase detectionBurkina FasoCase management systemDelivery systemTBCoughPatientsHospital
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