2022
BMPR1A promotes ID2–ZEB1 interaction to suppress excessive endothelial to mesenchymal transition
Lee H, Adachi T, Pak B, Park S, Hu X, Choi W, Kowalski PS, Chang CH, Clapham KR, Lee A, Papangeli I, Kim J, Han O, Park J, Anderson DG, Simons M, Jin S, Chun HJ. BMPR1A promotes ID2–ZEB1 interaction to suppress excessive endothelial to mesenchymal transition. Cardiovascular Research 2022, 119: 813-825. PMID: 36166408, PMCID: PMC10409893, DOI: 10.1093/cvr/cvac159.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein Receptors, Type IEndothelial CellsEndotheliumEpithelial-Mesenchymal TransitionHypertension, PulmonaryInhibitor of Differentiation Protein 2LungMicePulmonary Arterial HypertensionReceptor, Transforming Growth Factor-beta Type IIZinc Finger E-box-Binding Homeobox 1ConceptsPathogenesis of PAHPulmonary arterial hypertensionEndothelial cellsOnset of PAHAmeliorate pulmonary arterial hypertensionPotential novel therapeutic targetType 1 receptorType 2 receptorEndothelial-mesenchymal transitionNovel therapeutic targetGrowth factor-beta stimulationSmooth muscle cellsBone morphogenetic proteinPAH patientsArterial hypertensionVascular disordersBMP type 1 receptorsResponse of ECsAdult miceEndoMTTherapeutic targetBeta stimulationPathogenesisMesenchymal transitionMuscle cellsPressure‐based estimation of right ventricular ejection fraction
Heerdt PM, Singh I, Elassal A, Kheyfets V, Richter MJ, Tello K. Pressure‐based estimation of right ventricular ejection fraction. ESC Heart Failure 2022, 9: 1436-1443. PMID: 35150211, PMCID: PMC8934966, DOI: 10.1002/ehf2.13839.Peer-Reviewed Original ResearchConceptsRight ventricular ejection fractionCardiac magnetic resonance imagingRight heart catheterizationPulmonary arterial hypertensionMagnetic resonance imagingRV pressure waveformsVentricular ejection fractionRV responseEjection fractionMale PAH patientsCardiac MRI measurementsReceiver operator characteristic curvePressure waveformROC curve analysisClinical reference standardOperator characteristic curveSignificant reductionMeasurements of RVEFPAH patientsArterial hypertensionHeart catheterizationSecondary outcomesStudy cohortLimits of agreementBland-Altman analysis
2018
Neurohormonal modulation as therapeutic avenue for right ventricular dysfunction in pulmonary artery hypertension: till the dawn, waiting.
Emanuel R, Chichra A, Patel N, Le Jemtel TH, Jaiswal A. Neurohormonal modulation as therapeutic avenue for right ventricular dysfunction in pulmonary artery hypertension: till the dawn, waiting. Annals Of Translational Medicine 2018, 6: 301. PMID: 30211189, PMCID: PMC6123204, DOI: 10.21037/atm.2018.06.04.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPulmonary arterial hypertensionRight ventricular dysfunctionRV dysfunctionVentricular dysfunctionManagement of PAHAldosterone system modulationNeuro-hormonal activationPulmonary artery hypertensionBeta-adrenergic blockadeNon-pharmacological modalitiesCurrent clinical experienceArtery hypertensionArterial hypertensionNeurohormonal activationPAH patientsSystemic hypotensionAdrenergic blockadePathophysiological backgroundSignificant morbidityNeurohormonal modulationClinical studiesClinical experienceSystem modulationDysfunctionTherapeutic avenues
2016
Utility of B-type natriuretic peptides in the assessment of patients with systemic sclerosis-associated pulmonary hypertension in the PHAROS registry.
Chung L, Fairchild RM, Furst DE, Li S, Alkassab F, Bolster MB, Csuka ME, Derk CT, Domsic RT, Fischer A, Frech TM, Gomberg-Maitland M, Gordon JK, Hinchcliff M, Hsu V, Hummers LK, Khanna D, Medsger TAJ, Molitor JA, Preston IR, Schiopu E, Shapiro L, Hant F, Silver R, Simms R, Varga J, Steen VD, Zamanian RT. Utility of B-type natriuretic peptides in the assessment of patients with systemic sclerosis-associated pulmonary hypertension in the PHAROS registry. Clinical And Experimental Rheumatology 2016, 35 Suppl 106: 106-113. PMID: 27908301.Peer-Reviewed Original ResearchConceptsB-type natriuretic peptideNT-proBNP levelsPg/mLSSc-PHNT-proBNPPulmonary hypertensionSSc patientsSystemic sclerosisNatriuretic peptideBaseline B-type natriuretic peptideMedian B-type natriuretic peptideSystemic sclerosis-associated pulmonary hypertensionMulticenter prospective cohortNT-proBNP groupNatriuretic peptide levelsRight ventricular dysfunctionPredictors of mortalityPulmonary arterial hypertensionPredictors of progressionAssessment of patientsBaseline creatinineSSc-PAHArterial hypertensionPAH patientsVentricular dysfunctionRight atrial pressure/pulmonary artery wedge pressure ratio: A more specific predictor of survival in pulmonary arterial hypertension
Fares WH, Bellumkonda L, Tonelli AR, Carson SS, Hassoun PM, Trow TK, Herzog EL, Kaminski N, Kholdani CA, Zhang L, Zhou Y, Hammel JP, Dweik RA. Right atrial pressure/pulmonary artery wedge pressure ratio: A more specific predictor of survival in pulmonary arterial hypertension. The Journal Of Heart And Lung Transplantation 2016, 35: 760-767. PMID: 26856665, DOI: 10.1016/j.healun.2015.12.028.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionHemodynamic variablesArterial hypertensionCohort 2Cohort 1Accurate prognostic variableRelative prognostic valueSpecific predictorsCurrent prognostic modelsMultivariable regression modelsPAH registryPAH patientsHazard ratioPAH cohortReferral centerPrognostic valueMean ageClinical trialsClinical prognosticationPrognostic variablesSeparate cohortDisease statusFatal diseasePrognostic modelSecondary analysis
2012
Pediatric Pulmonary Arterial Hypertension and Hyperthyroidism: A Potentially Fatal Combination
Trapp CM, Elder RW, Gerken AT, Sopher AB, Lerner S, Aranoff GS, Rosenzweig EB. Pediatric Pulmonary Arterial Hypertension and Hyperthyroidism: A Potentially Fatal Combination. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: 2217-2222. PMID: 22622024, PMCID: PMC3387403, DOI: 10.1210/jc.2012-1109.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionAcute cardiopulmonary decompensationThyroid function testsCardiopulmonary decompensationAcute decompensationArterial hypertensionPAH patientsFunction testsPediatric pulmonary arterial hypertensionEmergency total thyroidectomySetting of hyperthyroidismStable PAH patientsTargeted PAH therapyRadioactive iodine ablationInstitutional review board approvalSymptoms of hyperthyroidismReview board approvalEmergency thyroidectomyPAH therapyIodine ablationTotal thyroidectomyΒ-blockadeAggressive treatmentPediatric patientsCardiopulmonary status
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