2025
Effects of Centro-Median Nucleus Stimulation on Interictal scalp EEG burden in LGS.
Sivaraju A, Poe J, Blumenfed H, Cukiert A. Effects of Centro-Median Nucleus Stimulation on Interictal scalp EEG burden in LGS. Stereotactic And Functional Neurosurgery 2025, 1-9. PMID: 40889229, DOI: 10.1159/000548242.Peer-Reviewed Original ResearchInterictal dischargesDeep brain stimulationAcute EEG changesDuration of EEG recordingSeizure reduction rateLennox-Gastaut syndromeOne-month post-surgeryExpert human readersShort durationCM-DBSLGS patientsLennox-GastautPredictive biomarkersBaseline EEGEEG changesTreatment optionsNon-respondersPost-surgeryInterictal activityThalamic nucleiClinical utilityPatientsEEG recordingsNucleus stimulationHypothesis-generatingStereotactic Laser Ablation vs Open Corpus Callosotomy: A Systematic Review and Meta-Analysis of Individual Patient Data.
Merenzon M, O'Malley G, Terry F, Sarwar S, Sturgill D, Ali M, Clocchiatti-Tuozzo S, Lehner K, Obaid S, Patel N, Anderson W, Danish S. Stereotactic Laser Ablation vs Open Corpus Callosotomy: A Systematic Review and Meta-Analysis of Individual Patient Data. Operative Neurosurgery 2025 PMID: 40719433, DOI: 10.1227/ons.0000000000001709.Peer-Reviewed Original ResearchLaser interstitial thermal therapyCorpus callosotomyIndependent predictorsSeizure outcomeSystematic reviewComplication rateIndependent predictors of seizure freedomPredictors of seizure freedomIndividual Patient Data Meta-AnalysisMultivariate logistic regression analysisSeizure reduction ratePatient data meta-analysisFollow-up durationMeta-analysisStereotactic laser ablationInterstitial thermal therapyLennox-Gastaut syndromeVagal nerve stimulationRefractory generalized epilepsyData Meta-AnalysisLogistic regression analysisIntervention typeConcurrent resectionFreedom ratesLennox-GastautEffectiveness and safety of perampanel in Lennox-Gastaut syndrome: a GRADE-assessed systematic review and meta-analysis
Kumar D, Sabet H, Elshahat A, El-Moslemani M, Arafa A, Saleh M, Gamal S, Abbas A. Effectiveness and safety of perampanel in Lennox-Gastaut syndrome: a GRADE-assessed systematic review and meta-analysis. Naunyn-Schmiedeberg's Archives Of Pharmacology 2025, 1-16. PMID: 40613940, DOI: 10.1007/s00210-025-04414-2.Peer-Reviewed Original ResearchLennox-Gastaut syndromeLennox-Gastaut syndrome patientsSafety of perampanelAdverse eventsBehavioral adverse eventsLennox-GastautAdjunctive therapySeizure freedomResponder rateDiscontinuation due to lackSystematic reviewPooled responder ratesIndividual risk-benefit evaluationConfidence intervalsSeizure freedom ratesPooled incidence rateComplete seizure freedomMeta-analysis aimComprehensive literature searchRandom-effects modelRisk-benefit evaluationChi-square testFreedom ratesWeb of ScienceSeizure aggravation
2024
Acquired, Lesional Lennox-Gastaut Syndrome
Herlopian A. Acquired, Lesional Lennox-Gastaut Syndrome. 2024, 919-943. DOI: 10.1007/978-3-031-23828-4_37.Peer-Reviewed Original ResearchCentromedian nucleusConfirm electrode placementGeneralized atonic seizuresLennox-Gastaut syndromeCentromedian thalamic nucleusLanguage lateralizationPost-operative language deficitsRare entityLennox-GastautCorpus callosotomySurgical interventionCortical malformationsAtonic seizuresSurgical proceduresThalamic nucleiCorpus callosumEpileptic networkDeep brain stimulation devicesLanguage deficitsNeurostimulation devicesElectrode placementPatientsNeurophysiological recordingsEpilepsyLanguage
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