2025
Cold snare endoscopic resection for large colon polyps: a randomised trial
Pohl H, Rex D, Barber J, Moyer M, Elmunzer B, Rastogi A, Gordon S, Zolotarevsky E, Levenick J, Aslanian H, Elatrache M, von Renteln D, Wallace M, Brahmbhatt B, Keswani R, Kumta N, Pleskow D, Smith Z, Abu Ghanimeh M, Simmer S, Sanaei O, Mackenzie T, Piraka C. Cold snare endoscopic resection for large colon polyps: a randomised trial. Gut 2025, gutjnl-2025-335075. PMID: 40393701, DOI: 10.1136/gutjnl-2025-335075.Peer-Reviewed Original ResearchCold endoscopic mucosal resectionEndoscopic mucosal resectionColorectal polypsSessile serrated polypsPrimary interventionEMR groupRandomised trialsSevere adverse eventsSerrated polypsMulticentre randomised trialPolyp sizePolyp recurrenceSecondary outcomesPrimary outcomeComplications of endoscopic mucosal resectionInterventionPolypsCold resectionRate of severe adverse eventsAntithrombotic medicationMucosal resectionColorectalPostprocedural bleedingComparative safetyEndoscopic resection
2021
Clip Closure Does Not Reduce Risk of Bleeding After Resection of Large Serrated Polyps: Results From a Randomized Trial
Crockett S, Khashab M, Rex D, Grimm I, Moyer M, Rastogi A, Mackenzie T, Pohl H, Consortium L, Al-Kawas F, Antaki F, Aslanian H, Crockett S, Elias P, Elmunzer B, Gill J, Gordon S, Grimm I, Hasan M, Khashab M, Law R, Levenick J, Mackenzie T, Mathew A, Moyer M, Ortiz O, Pellise M, Pleskow D, Pohl H, Rastogi A, von Renteln D, Rex D, Sanaei O. Clip Closure Does Not Reduce Risk of Bleeding After Resection of Large Serrated Polyps: Results From a Randomized Trial. Clinical Gastroenterology And Hepatology 2021, 20: 1757-1765.e4. PMID: 34971811, DOI: 10.1016/j.cgh.2021.12.036.Peer-Reviewed Original ResearchConceptsLarge serrated polypsEndoscopic mucosal resectionPost-procedure bleedingAdenomatous polypsBleeding rateProximal colonSerrated polypsControl groupLarge non-pedunculated polypsLimited clinical trial evidenceOverall serious adverse eventsPost-polypectomy bleeding rateDay of colonoscopyNon-pedunculated polypsSerious adverse eventsClinical trial evidenceRisk of bleedingColorectal cancer precursorsResection baseBleeding riskAdverse eventsMucosal resectionMulticenter trialPrimary outcomeProphylactic clippingDifferential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps
Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell 2021, 184: 6262-6280.e26. PMID: 34910928, PMCID: PMC8941949, DOI: 10.1016/j.cell.2021.11.031.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAdenomaAdultAgedAnimalsCarcinogenesisCell DeathCell DifferentiationColonic PolypsColorectal NeoplasmsDisease ProgressionFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksGenetic HeterogeneityHumansMaleMiceMiddle AgedMutationNeoplastic Stem CellsReproducibility of ResultsRNA-SeqSingle-Cell AnalysisTumor MicroenvironmentConceptsHuman colorectal polypsColorectal cancerColorectal polypsPrevention of CRCMicrosatellite-unstable colorectal cancersUnstable colorectal cancersGastric metaplasiaImmune microenvironmentTumor cell differentiation statusImmune cellsPrecision surveillancePrecursor polypsSerrated polypsConventional adenomasStem cell propertiesMalignant progressionImmunogenic potentialPolypsTumor cellsTherapeutic insightsCell differentiation statusCellular originMetaplasiaAdenomasMolecular heterogeneity
2019
Knowledge gaps in the appendix: a multi-institutional study from seven academic centers
Arnold CA, Graham RP, Jain D, Kakar S, Lam-Himlin DM, Naini BV, Wu TT, Yeh MM, Torbenson MS. Knowledge gaps in the appendix: a multi-institutional study from seven academic centers. Modern Pathology 2019, 32: 988-996. PMID: 30765881, DOI: 10.1038/s41379-019-0216-x.Peer-Reviewed Original ResearchConceptsLow-grade appendiceal mucinous neoplasmGrade appendiceal mucinous neoplasmAppendiceal mucinous neoplasmGoblet cell carcinoidMucinous neoplasmsCell carcinoidExtra-appendiceal mucinHigh-risk featuresUnique diagnostic challengeHigh-grade atypiaMulti-institutional studyAppendix pathologyDiverticular diseaseMucinous adenocarcinomaDiagnostic challengeSerrated polypsAcademic centersNeoplasmsCommon knowledge gapsCarcinoidsConsultsAdenocarcinomaAdditional studiesDiagnosisPathologists
2018
Clinical, Histologic, and Immunophenotypic Features of Serrated Polyps in Patients With Inflammatory Bowel Disease
Yang C, Tarabishy Y, Dassopoulos T, Nalbantoglu I. Clinical, Histologic, and Immunophenotypic Features of Serrated Polyps in Patients With Inflammatory Bowel Disease. Gastroenterology Research 2018, 11: 355-360. PMID: 30344807, PMCID: PMC6188039, DOI: 10.14740/gr1064w.Peer-Reviewed Original ResearchInflammatory bowel diseaseSSA/PsHyperplastic polypsSerrated polypsBowel diseaseSporadic serrated polypsLow-grade dysplasiaSessile serrated adenomas/polypsSerrated adenomas/polypsImmunohistochemistry staining patternsTraditional serrated adenomasSite-matched controlsColorectal serrated polypsAdenomas/polypsSporadic colorectal carcinomasOlder patientsClinicopathologic featuresImmunophenotypical featuresImmunophenotypic featuresColorectal carcinomaStudy groupPatientsSerrated adenomasStaining patternPolyps
2017
KRAS and BRAF somatic mutations in colonic polyps and the risk of metachronous neoplasia
Juárez M, Egoavil C, Rodríguez-Soler M, Hernández-Illán E, Guarinos C, García-Martínez A, Alenda C, Giner-Calabuig M, Murcia O, Mangas C, Payá A, Aparicio JR, Ruiz FA, Martínez J, Casellas JA, Soto JL, Zapater P, Jover R. KRAS and BRAF somatic mutations in colonic polyps and the risk of metachronous neoplasia. PLOS ONE 2017, 12: e0184937. PMID: 28953955, PMCID: PMC5617162, DOI: 10.1371/journal.pone.0184937.Peer-Reviewed Original ResearchConceptsAdvanced adenomasKRAS mutationsColonic polypsAdvanced neoplasiaAdvanced polypsMetachronous advanced neoplasiaHigh-grade dysplasiaSomatic KRAS mutationsBRAF somatic mutationsMetachronous neoplasiaSurveillance colonoscopyPathologic characteristicsSplenic flexureGrade dysplasiaVillous componentUnivariate analysisSerrated polypsRisk featuresSomatic BRAFMultivariate analysisAdenomasAbstractTextPolypsPatientsNeoplasia
2016
High-quality Bowel Preparation Is Required for Detection of Sessile Serrated Polyps
Clark BT, Laine L. High-quality Bowel Preparation Is Required for Detection of Sessile Serrated Polyps. Clinical Gastroenterology And Hepatology 2016, 14: 1155-1162. PMID: 27060426, PMCID: PMC4955697, DOI: 10.1016/j.cgh.2016.03.044.Peer-Reviewed Original ResearchConceptsSessile serrated adenomas/polypsBowel preparation qualityProportion of patientsDetection of adenomasPreparation qualityRight colonBBPS scoresHigh-quality bowel preparationBoston Bowel Preparation ScaleMultivariate logistic regressionBowel Preparation ScaleSerrated adenomas/polypsSessile serrated polypsAdenomas/polypsSurveillance colonoscopyBowel preparationProspective studyAronchick scaleEntire colonSmall proportionSerrated polypsPatientsPreparation ScaleScoring systemAbstractText
2015
Clinical, pathologic, and outcome study of hyperplastic and sessile serrated polyps in inflammatory bowel disease
Shen J, Gibson JA, Schulte S, Khurana H, Farraye FA, Levine J, Burakoff R, Cerda S, Qazi T, Hamilton M, Srivastava A, Odze RD. Clinical, pathologic, and outcome study of hyperplastic and sessile serrated polyps in inflammatory bowel disease. Human Pathology 2015, 46: 1548-1556. PMID: 26297256, DOI: 10.1016/j.humpath.2015.06.019.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseNeoplastic lesionsHyperplastic polypsFlat dysplasiaIBD patientsBowel diseaseAdenoma-like dysplasiaTraditional serrated adenomasSessile serrated polypsAverage followSurgical resectionClinicopathological featuresColon resectionSporadic adenomasSerrated polypsLower riskSerrated pathwayPatientsSerrated adenomasLesionsDysplasiaAdenoma/AdenocarcinomaResectionAdenomasMulti-Center Colonoscopy Quality Measurement Utilizing Natural Language Processing
Imler TD, Morea J, Kahi C, Sherer EA, Cardwell J, Johnson CS, Xu H, Ahnen D, Antaki F, Ashley C, Baffy G, Cho I, Dominitz J, Hou J, Korsten M, Nagar A, Promrat K, Robertson D, Saini S, Shergill A, Smalley W, Imperiale TF. Multi-Center Colonoscopy Quality Measurement Utilizing Natural Language Processing. The American Journal Of Gastroenterology 2015, 110: 543. PMID: 25756240, DOI: 10.1038/ajg.2015.51.Peer-Reviewed Original ResearchConceptsNatural language processingSurveillance intervalsHyperplastic polypsColorectal cancer screeningColonoscopy surveillance intervalsLarge hyperplastic polypsNumber of adenomasAdenoma detection rateSmall hyperplastic polypsSessile serrated polypsColonoscopy quality measuresLanguage processingManual reviewColonoscopy findingsAdvanced adenomasPrimary outcomePathologic findingsPathology recordsCancer screeningSerrated polypsLesion locationColonoscopy qualityExpert manual review
2011
MUC Expression in Hyperplastic and Serrated Colonic Polyps
Gibson JA, Hahn HP, Shahsafaei A, Odze RD. MUC Expression in Hyperplastic and Serrated Colonic Polyps. The American Journal Of Surgical Pathology 2011, 35: 742-749. PMID: 21490447, DOI: 10.1097/pas.0b013e31821537a2.Peer-Reviewed Original ResearchConceptsSSA/PExpression of MUC6Hyperplastic polypsSerrated polypsSSA/PsPolyp groupRight colonMUC expressionColonic polypsSerrated colonic polypsSessile serrated adenomas/polypsSerrated adenomas/polypsTraditional serrated adenomasGoblet cell typeProgression of malignancyAdenomas/polypsIntensity of stainingDifferent anatomic locationsMicrovesicular typeSerrated carcinogenesisDifferential diagnosisMUC6 expressionAnatomic locationSerrated pathwaySerrated adenomas
2008
Serrated Polyps With “Intermediate Features” of Sessile Serrated Polyp and Microvesicular Hyperplastic Polyp
Chung S, Chen Y, Panczykowski A, Schamberg N, Klimstra D, Yantiss R. Serrated Polyps With “Intermediate Features” of Sessile Serrated Polyp and Microvesicular Hyperplastic Polyp. The American Journal Of Surgical Pathology 2008, 32: 407-412. PMID: 18300810, DOI: 10.1097/pas.0b013e318158dde2.Peer-Reviewed Original ResearchConceptsSessile serrated polypsNondysplastic serrated polypsMicrovesicular hyperplastic polypsSerrated polypsHyperplastic polypsKRAS mutation statusColorectal cancer riskO6-methylguanine methyltransferaseMolecular featuresMutation statusKi-67BRAF mutationsProximal colon carcinomasStudy polypsMUC5AC expressionColon carcinomaExpressed MUC5ACCancer riskDistal lesionsProspective dataMethyltransferase expressionDiagnostic criteriaNatural historyPolypsBRAF
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