2016
Serrated colorectal cancer: Molecular classification, prognosis, and response to chemotherapy
Murcia O, Juárez M, Hernández-Illán E, Egoavil C, Giner-Calabuig M, Rodríguez-Soler M, Jover R. Serrated colorectal cancer: Molecular classification, prognosis, and response to chemotherapy. World Journal Of Gastroenterology 2016, 22: 3516-3530. PMID: 27053844, PMCID: PMC4814638, DOI: 10.3748/wjg.v22.i13.3516.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsBiomarkers, TumorColorectal NeoplasmsCpG IslandsDNA MethylationGenetic Predisposition to DiseaseHumansMicrosatellite InstabilityMolecular Diagnostic TechniquesMutationNeoplasm StagingPhenotypePredictive Value of TestsProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)Treatment OutcomeConceptsColorectal cancerSerrated pathwayGene mutationsKRAS gene mutationsBRAF gene mutationClinical featuresColorectal carcinogenesisMolecular alterationsMicrosatellite instabilityHistological analysisSerrated appearanceTumor suppressor geneMolecular classificationAlternative pathwayChemotherapyPrognosisMolecular advancesSuppressor geneGenetic profileNew classificationPathwayHypermethylationTumorsCancerMutations
2015
Clinical, pathologic, and outcome study of hyperplastic and sessile serrated polyps in inflammatory bowel disease
Shen J, Gibson JA, Schulte S, Khurana H, Farraye FA, Levine J, Burakoff R, Cerda S, Qazi T, Hamilton M, Srivastava A, Odze RD. Clinical, pathologic, and outcome study of hyperplastic and sessile serrated polyps in inflammatory bowel disease. Human Pathology 2015, 46: 1548-1556. PMID: 26297256, DOI: 10.1016/j.humpath.2015.06.019.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseNeoplastic lesionsHyperplastic polypsFlat dysplasiaIBD patientsBowel diseaseAdenoma-like dysplasiaTraditional serrated adenomasSessile serrated polypsAverage followSurgical resectionClinicopathological featuresColon resectionSporadic adenomasSerrated polypsLower riskSerrated pathwayPatientsSerrated adenomasLesionsDysplasiaAdenoma/AdenocarcinomaResectionAdenomas
2011
MUC Expression in Hyperplastic and Serrated Colonic Polyps
Gibson JA, Hahn HP, Shahsafaei A, Odze RD. MUC Expression in Hyperplastic and Serrated Colonic Polyps. The American Journal Of Surgical Pathology 2011, 35: 742-749. PMID: 21490447, DOI: 10.1097/pas.0b013e31821537a2.Peer-Reviewed Original ResearchConceptsSSA/PExpression of MUC6Hyperplastic polypsSerrated polypsSSA/PsPolyp groupRight colonMUC expressionColonic polypsSerrated colonic polypsSessile serrated adenomas/polypsSerrated adenomas/polypsTraditional serrated adenomasGoblet cell typeProgression of malignancyAdenomas/polypsIntensity of stainingDifferent anatomic locationsMicrovesicular typeSerrated carcinogenesisDifferential diagnosisMUC6 expressionAnatomic locationSerrated pathwaySerrated adenomas
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