2025
Cold snare endoscopic resection for large colon polyps: a randomised trial
Pohl H, Rex D, Barber J, Moyer M, Elmunzer B, Rastogi A, Gordon S, Zolotarevsky E, Levenick J, Aslanian H, Elatrache M, von Renteln D, Wallace M, Brahmbhatt B, Keswani R, Kumta N, Pleskow D, Smith Z, Abu Ghanimeh M, Simmer S, Sanaei O, Mackenzie T, Piraka C. Cold snare endoscopic resection for large colon polyps: a randomised trial. Gut 2025, gutjnl-2025-335075. PMID: 40393701, DOI: 10.1136/gutjnl-2025-335075.Peer-Reviewed Original ResearchCold endoscopic mucosal resectionEndoscopic mucosal resectionColorectal polypsSessile serrated polypsPrimary interventionEMR groupRandomised trialsSevere adverse eventsSerrated polypsMulticentre randomised trialPolyp sizePolyp recurrenceSecondary outcomesPrimary outcomeComplications of endoscopic mucosal resectionInterventionPolypsCold resectionRate of severe adverse eventsAntithrombotic medicationMucosal resectionColorectalPostprocedural bleedingComparative safetyEndoscopic resectionIncreased risk of colorectal adenoma and benign colorectal polyp associated with Helicobacter pylori infection: a systematic review and meta-analysis
Kim J, Han H, Song J, Kim S, Kim Y, Kim H, Rhee T, Shim S. Increased risk of colorectal adenoma and benign colorectal polyp associated with Helicobacter pylori infection: a systematic review and meta-analysis. Translational Cancer Research 2025, 0: 0-0. PMID: 40386279, PMCID: PMC12079237, DOI: 10.21037/tcr-24-795.Peer-Reviewed Original ResearchBenign colorectal polypsAdvanced colorectal adenomaRisk of colorectal adenomaColorectal adenomasMeta-regression analysisIncreased risk of colorectal adenomaMeta-analysisSystematic reviewMeta-analysis findingsColorectal polypsAssociated with increased probabilityComprehensive literature searchCochrane DatabaseHelicobacter pylori infectionIncreased riskRisk factorsLiterature searchPotential moderatorsSubgroup analysisStatistically significant differenceHistological subtypesEffects of <i>H. pyPylori infectionEthnicityRisk
2021
Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps
Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell 2021, 184: 6262-6280.e26. PMID: 34910928, PMCID: PMC8941949, DOI: 10.1016/j.cell.2021.11.031.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAdenomaAdultAgedAnimalsCarcinogenesisCell DeathCell DifferentiationColonic PolypsColorectal NeoplasmsDisease ProgressionFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksGenetic HeterogeneityHumansMaleMiceMiddle AgedMutationNeoplastic Stem CellsReproducibility of ResultsRNA-SeqSingle-Cell AnalysisTumor MicroenvironmentConceptsHuman colorectal polypsColorectal cancerColorectal polypsPrevention of CRCMicrosatellite-unstable colorectal cancersUnstable colorectal cancersGastric metaplasiaImmune microenvironmentTumor cell differentiation statusImmune cellsPrecision surveillancePrecursor polypsSerrated polypsConventional adenomasStem cell propertiesMalignant progressionImmunogenic potentialPolypsTumor cellsTherapeutic insightsCell differentiation statusCellular originMetaplasiaAdenomasMolecular heterogeneityFactors associated with complete clip closure after endoscopic mucosal resection of large colorectal polyps
Ortiz O, Rex DK, Grimm IS, Moyer MT, Hasan MK, Pleskow D, Elmunzer BJ, Khashab MA, Sanaei O, Al-Kawas FH, Gordon SR, Mathew A, Levenick JM, Aslanian H, Antaki F, von Renteln D, Crockett SD, Rastogi A, Gill JA, Law R, Wallace MB, Elias PA, MacKenzie TA, Pohl H, Pellisé M. Factors associated with complete clip closure after endoscopic mucosal resection of large colorectal polyps. Endoscopy 2021, 53: 1150-1159. PMID: 33291159, DOI: 10.1055/a-1332-6727.Peer-Reviewed Original ResearchConceptsEndoscopic mucosal resectionProphylactic clip closureLarge colorectal polypsClip closureMucosal defectsMucosal resectionColorectal polypsLarge polypsResection defectsComplete closureCommon adverse eventsSubmucosal liftingAdverse eventsBloc resectionMultivariable analysisProximal polypsSerrated histologyClip groupMAIN OUTCOMECLIP studyStudy aimPolyp sizeResectionPolypsPatients
2019
215 ELECTROCAUTERY SETTING DOES NOT AFFECT EFFICACY AND SAFETY OF ENDOSCOPIC RESECTION OF LARGE COLORECTAL POLYPS
Pohl H, Grimm I, Moyer M, Hasan M, Pleskow D, Elmunzer B, Khashab M, Sanaei O, al Kawas F, Gordon S, Mathew A, Levenick J, Aslanian H, Antaki F, von Renteln D, Crockett S, Rastogi A, Gill J, Law R, Elias P, Pellise M, MacKenzie T, Rex D. 215 ELECTROCAUTERY SETTING DOES NOT AFFECT EFFICACY AND SAFETY OF ENDOSCOPIC RESECTION OF LARGE COLORECTAL POLYPS. Gastrointestinal Endoscopy 2019, 89: ab64. DOI: 10.1016/j.gie.2019.04.030.Peer-Reviewed Original ResearchELECTROCAUTERY SETTING DOES NOT AFFECT EFFICACY AND SAFETY OF ENDOSCOPIC RESECTION OF LARGE COLORECTAL POLYPS
Pohl H, Grimm I, Moyer M, Hasan M, Pleskow D, Elmunzer B, Khashab M, Sanaei O, Al-Kawas F, Gordon, Mathew A, Levenick J, Aslanian H, Antaki F, Renteln D, Crockett S, Rastogi A, Gill J, Law R, Elias P, Pellise M, Mackenzie T, Rex D. ELECTROCAUTERY SETTING DOES NOT AFFECT EFFICACY AND SAFETY OF ENDOSCOPIC RESECTION OF LARGE COLORECTAL POLYPS. Endoscopy 2019, 51: s32-s33. DOI: 10.1055/s-0039-1681265.Peer-Reviewed Original ResearchFACTORS ASSOCIATED WITH DIFFICULTY IN PROPHYLACTIC CLIP CLOSURE AFTER ENDOSCOPIC MUCOSAL RESECTION OF LARGE COLORECTAL POLYPS
Ortiz O, Pellise M, Rex D, Grimm I, Moyer M, Hasan M, Pleskow D, Elmunzer B, Kashab M, Sanaei O, Al-Kawas F, Gordon S, Mathew A, Levenick J, Aslanian H, Antaki F, Von Renteln D, Crockett S, Rastogi A, Gill J, Law R, Elias P, Mackenzie T, Pohl H. FACTORS ASSOCIATED WITH DIFFICULTY IN PROPHYLACTIC CLIP CLOSURE AFTER ENDOSCOPIC MUCOSAL RESECTION OF LARGE COLORECTAL POLYPS. Endoscopy 2019, 51: s191-s191. DOI: 10.1055/s-0039-1681735.Peer-Reviewed Original Research
2017
Outcomes following polypectomy for malignant colorectal polyps are similar to those following surgery in the general population
Lopez A, Bouvier A, Jooste V, Cottet V, Romain G, Faivre J, Manfredi S, Lepage C. Outcomes following polypectomy for malignant colorectal polyps are similar to those following surgery in the general population. Gut 2017, 68: 111. PMID: 29074726, DOI: 10.1136/gutjnl-2016-312093.Peer-Reviewed Original ResearchConceptsSessile malignant polypsColorectal malignant polypsMalignant polypsPathological marginsEndoscopic resectionSurgical resectionRecurrence rateGeneral populationAge-standardised incidence ratesFive-year net survivalAge-standardised incidenceCumulative recurrence ratePopulation-based studyMalignant colorectal polypsTransanal resectionIncidence rateResectionColorectal polypsNet survivalPatientsSurvival analysisSurgeryPolypectomyTime trendsOutcomes
2016
Pathology of premalignant colorectal neoplasia
Gibson JA, Odze RD. Pathology of premalignant colorectal neoplasia. Digestive Endoscopy 2016, 28: 312-323. PMID: 26861656, DOI: 10.1111/den.12633.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsColorectal cancerPrecursor lesionsColorectal carcinogenesisMolecular featuresManagement of patientsNeoplastic precursor lesionsEpithelial precursor lesionsScreening colonoscopyColorectal neoplasiaColorectal carcinomaColorectal polypsColon cancerPersonalized treatmentOncological diseasesCancerEarly detectionMolecular pathwaysPatientsLesionsEarly phasePresent reviewCarcinogenesisSignificant changesColonoscopyCarcinoma
2009
Mucosal Schwann Cell “Hamartoma”
Gibson JA, Hornick JL. Mucosal Schwann Cell “Hamartoma”. The American Journal Of Surgical Pathology 2009, 33: 781-787. PMID: 19065103, DOI: 10.1097/pas.0b013e31818dd6ca.Peer-Reviewed Original ResearchMeSH KeywordsActinsAgedAged, 80 and overAntigens, CD34Cell DifferentiationCell ProliferationClaudin-1Colonic PolypsColonoscopyColorectal NeoplasmsDiagnosis, DifferentialFemaleGlial Fibrillary Acidic ProteinHamartomaHumansImmunohistochemistryIncidental FindingsIntestinal MucosaMaleMembrane ProteinsMiddle AgedMucin-1Neurofibromatosis 1Neurofilament ProteinsNeuromaProto-Oncogene Proteins c-kitS100 ProteinsSchwann CellsConceptsLamina propriaHistologic featuresGanglion cellsSchwann cellsColorectal polypsNF1 patientsNeurofilament proteinDense eosinophilic cytoplasmGlial fibrillary acidic proteinSolitary colorectal polypsSimilar histologic featuresBland spindle cellsIndistinct cell bordersType 1 neurofibromatosisEpithelial membrane antigenFibrillary acidic proteinSchwann cell proliferationSmooth muscle actinUniform bland spindle cellsRare axonsMucosal biopsiesPositive axonsImmunohistochemical featuresNeural lesionsIntralesional heterogeneity
2008
Narrow-band imaging without high magnification to differentiate polyps during real-time colonoscopy: improvement with experience
Rogart JN, Jain D, Siddiqui UD, Oren T, Lim J, Jamidar P, Aslanian H. Narrow-band imaging without high magnification to differentiate polyps during real-time colonoscopy: improvement with experience. Gastrointestinal Endoscopy 2008, 68: 1136-1145. PMID: 18691708, DOI: 10.1016/j.gie.2008.04.035.Peer-Reviewed Original ResearchConceptsNarrow-band imagingNonadenomatous polypsColorectal polypsSingle tertiary referral centerReal-time colonoscopyTertiary referral centerKudo pit patternLearning curvePit pattern classificationWL colonoscopyEndoscopic diagnosisColonoscopyClinical decisionDiagnostic accuracyPatientsPolypsEndoscopist performancePit patternAdenomasTotalVivoPolypectomyHistology
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