2025
Cold snare endoscopic resection for large colon polyps: a randomised trial
Pohl H, Rex D, Barber J, Moyer M, Elmunzer B, Rastogi A, Gordon S, Zolotarevsky E, Levenick J, Aslanian H, Elatrache M, von Renteln D, Wallace M, Brahmbhatt B, Keswani R, Kumta N, Pleskow D, Smith Z, Abu Ghanimeh M, Simmer S, Sanaei O, Mackenzie T, Piraka C. Cold snare endoscopic resection for large colon polyps: a randomised trial. Gut 2025, gutjnl-2025-335075. PMID: 40393701, DOI: 10.1136/gutjnl-2025-335075.Peer-Reviewed Original ResearchCold endoscopic mucosal resectionEndoscopic mucosal resectionColorectal polypsSessile serrated polypsPrimary interventionEMR groupRandomised trialsSevere adverse eventsSerrated polypsMulticentre randomised trialPolyp sizePolyp recurrenceSecondary outcomesPrimary outcomeComplications of endoscopic mucosal resectionInterventionPolypsCold resectionRate of severe adverse eventsAntithrombotic medicationMucosal resectionColorectalPostprocedural bleedingComparative safetyEndoscopic resection
2021
Factors associated with complete clip closure after endoscopic mucosal resection of large colorectal polyps
Ortiz O, Rex DK, Grimm IS, Moyer MT, Hasan MK, Pleskow D, Elmunzer BJ, Khashab MA, Sanaei O, Al-Kawas FH, Gordon SR, Mathew A, Levenick JM, Aslanian H, Antaki F, von Renteln D, Crockett SD, Rastogi A, Gill JA, Law R, Wallace MB, Elias PA, MacKenzie TA, Pohl H, Pellisé M. Factors associated with complete clip closure after endoscopic mucosal resection of large colorectal polyps. Endoscopy 2021, 53: 1150-1159. PMID: 33291159, DOI: 10.1055/a-1332-6727.Peer-Reviewed Original ResearchConceptsEndoscopic mucosal resectionProphylactic clip closureLarge colorectal polypsClip closureMucosal defectsMucosal resectionColorectal polypsLarge polypsResection defectsComplete closureCommon adverse eventsSubmucosal liftingAdverse eventsBloc resectionMultivariable analysisProximal polypsSerrated histologyClip groupMAIN OUTCOMECLIP studyStudy aimPolyp sizeResectionPolypsPatientsEffects of Somatic Methylation in Colonic Polyps on Risk of Developing Metachronous Advanced Colorectal Lesions
Murcia O, Martínez-Roca A, Juárez M, Giner-Calabuig M, Alustiza M, Mira C, Mangas-Sanjuan C, Serrano E, Ruiz-Gómez FA, Baile-Maxia S, Medina L, Alenda C, Payá A, Rodriguez-Soler M, Zapater P, Jover R. Effects of Somatic Methylation in Colonic Polyps on Risk of Developing Metachronous Advanced Colorectal Lesions. Cancers 2021, 13: 246. PMID: 33440809, PMCID: PMC7827613, DOI: 10.3390/cancers13020246.Peer-Reviewed Original ResearchCpG island methylator phenotypeAdvanced colorectal lesionsColorectal lesionsColonic polypsRetrospective cohort studyHigh-grade dysplasiaNegative predictive valueBaseline colonoscopyCohort studyConsecutive patientsEndoscopic surveillancePathological characteristicsVillous componentSerrated lesionsPredictive valuePatientsUseful markerSomatic hypermethylationPolyp sizePolypsLesionsMethylator phenotypeSomatic methylationDysplasiaRisk
2019
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT. Nasal polyps and rhinosinusitis. Allergy & Asthma Proceedings 2019, 40: 380-384. PMID: 31690375, DOI: 10.2500/aap.2019.40.4252.Peer-Reviewed Original ResearchConceptsAspirin-exacerbated respiratory diseaseChronic rhinosinusitisNasal polypsNasal congestionEthmoid sinusSinus cavityCiliated columnar epithelial cellsPolyp sizeAcute sinus infectionsTopical nasal steroidsAnterior ethmoid sinusChronic mucosal inflammationAllergic fungal rhinosinusitisMajority of patientsTreatment of choiceParanasal sinus mucosaPosterior ethmoid sinusColumnar epithelial cellsAspirin desensitizationIntranasal corticosteroidsNasal steroidsOral steroidsAcute rhinosinusitisMaintenance therapyPersistent asthma
2018
Magnetic Resonance Imaging Features of Endometrial Polyps
Balcacer P, Cooper KA, Huber S, Spektor M, Pahade JK, Israel GM. Magnetic Resonance Imaging Features of Endometrial Polyps. Journal Of Computer Assisted Tomography 2018, 42: 721-726. PMID: 29901509, DOI: 10.1097/rct.0000000000000765.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingEndometrial polypsResonance imagingMagnetic resonance imaging featuresInterobserver agreementInstitutional review board approvalReview board approvalModerate interobserver agreementPresence of polypsMRI pelvisStudy cohortSurgical interventionImaging featuresPolyp characteristicsBoard approvalIntratumoral cystsT2 signalPolyp sizeSlight agreementPolypsModerate agreementReader 1Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations
Druliner B, Wang P, Bae T, Baheti S, Slettedahl S, Mahoney D, Vasmatzis N, Xu H, Kim M, Bockol M, O’Brien D, Grill D, Warner N, Munoz-Gomez M, Kossick K, Johnson R, Mouchli M, Felmlee-Devine D, Washechek-Aletto J, Smyrk T, Oberg A, Wang J, Chia N, Abyzov A, Ahlquist D, Boardman L. Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations. Scientific Reports 2018, 8: 3161. PMID: 29453410, PMCID: PMC5816667, DOI: 10.1038/s41598-018-21525-4.Peer-Reviewed Original ResearchConceptsColorectal cancerManagement of polypsPolyp patientsPolyp groupMalignant polypsPrecursor lesionsColorectal adenomasResidual polypPolyp tissuesPolyp sizePolypsCancerAltered expressionMethylome alterationsPatientsWhole-genome sequencingTissueMore mutationsAlterationsExpression changesSignificant expression changesMolecular determinantsMethylation alterationsMolecular distinctionMolecular characterization
2009
Polypoid Lesions of the Gallbladder: Diagnosis and Followup
Ito H, Hann L, D'Angelica M, Allen P, Fong Y, Dematteo R, Klimstra D, Blumgart L, Jarnagin W. Polypoid Lesions of the Gallbladder: Diagnosis and Followup. Journal Of The American College Of Surgeons 2009, 208: 570-575. PMID: 19476792, DOI: 10.1016/j.jamcollsurg.2009.01.011.Peer-Reviewed Original ResearchConceptsPolypoid lesionsRisk of invasive cancerIn situ cancerAbdominal USInvasive cancerMedian ageGallbladder cancerInfiltrative massAbdominal symptomsNo polypAssociated with symptomsHistological findingsPolyp sizeUltrasonographyHistological characteristicsOptimal managementPatientsNatural historyNeoplastic polypsGallbladderPolypsLesionsCancerCholecystectomyFollowup
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