2020
Effects of Cytokines and Nitric Oxide on Bicarbonate Secretion by Cholangiocytes
Spirlì C, Okolicsanyi L, Strazzabosco M. Effects of Cytokines and Nitric Oxide on Bicarbonate Secretion by Cholangiocytes. 2020, 81-88. DOI: 10.1201/9780367813888-7.Peer-Reviewed Original ResearchInflammatory mediatorsBiliary epitheliumRole of inflammationSecretory mechanismElectrolyte transportEffects of cytokinesPathophysiology of cholangiopathiesProgressive cholestasisFibrogenetic processInhibition of cAMPProliferative responseBicarbonate secretionPathogenetic sequenceCholestasisDuctal cholestasisCAMP formationCholangiopathyNitric oxideAvailable evidenceCell damageAdenylyl cyclaseCytokinesMediatorsCholangiocytesEpithelium
2003
Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes
Spirlì C, Fabris L, Duner E, Fiorotto R, Ballardini G, Roskams T, Larusso NF, Sonzogni A, Okolicsanyi L, Strazzabosco M. Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes. Gastroenterology 2003, 124: 737-753. PMID: 12612912, DOI: 10.1053/gast.2003.50100.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl Cyclase InhibitorsAdenylyl CyclasesAnimalsBile DuctsBile Ducts, IntrahepaticCell LineCyclic AMPDrug SynergismGene ExpressionHumansInterferon-gammaIntracellular FluidIon TransportLiver DiseasesNitratesNitric OxideNitric Oxide DonorsNitric Oxide SynthaseNitric Oxide Synthase Type IINitritesRatsTumor Necrosis Factor-alphaConceptsPrimary sclerosing cholangitisProinflammatory cytokinesBiliary epitheliumAdenylyl cyclaseHuman chronic liver diseaseInducible nitric oxide synthaseChronic liver diseaseSecretory mechanismInhibition of ACNitric oxide synthaseTumor necrosis factorDependent fluid secretionReactive nitrogen oxide speciesCAMP-dependent secretionNOS-2 inhibitorCystic fibrosis transmembrane conductance regulatorCAMP-dependent ClDuctular cholestasisProgressive cholestasisSclerosing cholangitisLiver diseaseCholestatic effectLiver damageBile productionNOS2 induction
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply