2024
Mouse Models of Hereditary Xerocytosis-Associated PIEZO1 Mutations Reveal Genotype-Phenotype Differences in Hematological Defects and Iron Loading
Finberg K, Peres Diaz L, Shan P, Chua E, Lalwani K, Gallagher P. Mouse Models of Hereditary Xerocytosis-Associated PIEZO1 Mutations Reveal Genotype-Phenotype Differences in Hematological Defects and Iron Loading. Blood 2024, 144: 3851-3851. DOI: 10.1182/blood-2024-203740.Peer-Reviewed Original ResearchRed cell distribution widthHereditary xerocytosisSpleen weight/body weight ratioRed blood cell countMean corpuscular volumeCompared to wild-typeHematological defectsMouse modelHeart weight/body weight ratioWild-typeIron loadingComplete blood count analysisRed blood cell turnoverSerum transferrin saturationC57BL/6 genetic backgroundSerum hepcidin levelsLiver iron loadingYoung adult miceGenotype-phenotype differencesCell distribution widthMean corpuscular hemoglobinGain-of-function mutationsBlood count analysisNon-heme iron concentrationsRed cell indicesHematocrits of red blood cell units increase during storage due to changes in mean corpuscular volume, impacting outcomes of red cell exchange procedures
Lee E, Musante K, Errico J, Rinder H, Kleinstein S, Tormey C, Yurtsever N. Hematocrits of red blood cell units increase during storage due to changes in mean corpuscular volume, impacting outcomes of red cell exchange procedures. American Journal Of Clinical Pathology 2024, 162: s157-s157. DOI: 10.1093/ajcp/aqae129.348.Peer-Reviewed Original ResearchMean corpuscular volumeMultilevel linear regression modelsPosterior meanStorage timeWeeks of storageRed blood cell exchangeFunction of storage timeLinear regression modelsRed blood cell unitsPosterior distribution of model parametersAkaike weightsMultilevel regression modelsRegression modelsRed blood cellsPosterior distributionDistribution of model parametersRBC unitsModel selectionRStan packageCorpuscular volumeHematological parametersEvaluation of mean corpuscular volume among anemic people with HIV in North America following ART initiation
Lang R, Coburn S, Gill M, Justice A, Grossman J, Gebo K, Horberg M, Mayor A, Silverberg M, McGinnis K, Hogan B, Moore R, Althoff K. Evaluation of mean corpuscular volume among anemic people with HIV in North America following ART initiation. AIDS Research And Therapy 2024, 21: 52. PMID: 39113038, PMCID: PMC11304803, DOI: 10.1186/s12981-024-00641-4.Peer-Reviewed Original ResearchConceptsAntiretroviral therapy initiationAntiretroviral therapyNormocytic anemiaMicrocytic anemiaMean corpuscular volumeRisk factorsMacrocytic anemiaAssociated with increased morbidityCausative factors of anemiaProportion of PWHFactors of anemiaAssociated with increasing ageClassification of anemiaIdentified risk factorsAnemic peopleCD4 countHIV factorsNA-ACCORDLow hemoglobinAnemiaPWHEstimate crudeRobust varianceHemoglobin measurementsHIV
2019
Transcranial Doppler Screening in Children with Sickle Cell Anemia Is Feasible in Central India and Reveals High Risk of Stroke
Jain D, Ganesan K, Sahota S, Darbari D, Krishnamurti L, Kirkham F. Transcranial Doppler Screening in Children with Sickle Cell Anemia Is Feasible in Central India and Reveals High Risk of Stroke. Blood 2019, 134: 2279. DOI: 10.1182/blood-2019-131416.Peer-Reviewed Original ResearchWhite blood cell countBody mass indexMean corpuscular volumeSickle cell anemiaPosterior cerebral arteryTranscranial DopplerHeight/weightNormal rangeCerebral arteryHigh riskNon-tribal populationCell anemiaHomozygous sickle cell anemiaIntracranial blood flow velocityTranscranial Doppler screeningAnterior cerebral arteryTertiary care centerRisk of strokeBlood cell countCross-sectional studyBlood flow velocityQuarter of childrenTerms of ageDepartment of RadiologyAdvisory board meetings
2014
A pilot study of electronic directly observed therapy to improve hydroxyurea adherence in pediatric patients with sickle‐cell disease
Creary S, Gladwin M, Byrne M, Hildesheim M, Krishnamurti L. A pilot study of electronic directly observed therapy to improve hydroxyurea adherence in pediatric patients with sickle‐cell disease. Pediatric Blood & Cancer 2014, 61: 1068-1073. PMID: 24436121, DOI: 10.1002/pbc.24931.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnemia, Sickle CellAntisickling AgentsCell PhoneChildChild, PreschoolDirectly Observed TherapyDrug Administration ScheduleElectronic MailFeedbackFemaleHealth SurveysHumansHydroxyureaMaleMedication AdherenceMicrocomputersPatient SatisfactionPilot ProjectsReimbursement, IncentiveReminder SystemsRewardText MessagingVideo RecordingYoung AdultConceptsSickle cell diseaseMedian medication possession ratioMean corpuscular volumeHU adherenceHydroxyurea adherencePilot studyHemoglobin F percentageMedication possession ratioParticipant satisfactionPossession ratioSecondary outcomesPediatric patientsPrimary outcomeStudy entryClinical outcomesHU useHU therapyOverall participant satisfactionSingle institutionCell diseaseReminder alertsCorpuscular volumeTherapyAdherenceOverall median
2012
Anaemia in pregnancy in the district of Anuradhapura, Sri Lanka – need for updating prevalence data and screening strategies
Chathurani U, Dharshika I, Galgamuwa D, Wickramasinghe N, Agampodi T, Agampodi S. Anaemia in pregnancy in the district of Anuradhapura, Sri Lanka – need for updating prevalence data and screening strategies. Ceylon Medical Journal 2012, 57: 101-6. PMID: 23086024, DOI: 10.4038/cmj.v57i3.4148.Peer-Reviewed Original ResearchConceptsPrevalence of anemiaMean corpuscular hemoglobin concentrationMean corpuscular volumePregnant womenMean corpuscular hemoglobinDistrict of AnuradhapuraHemoglobin concentrationAnemic pregnant womenMedian hemoglobin concentrationCorpuscular hemoglobin concentrationAnuradhapura districtHaemoglobin Colour ScaleAntenatal clinicSerum hemoglobinGestational ageThird trimesterAnemia prevalenceMethemoglobin methodClinical examinationStudy populationAnemiaCorpuscular volumePregnancyPrevalence dataCorpuscular hemoglobin
2011
Effect of Hydroxyurea on Elevated Pulmonary Artery Pressures in Children with Sickle Cell Disease
Pashankar F, Manwani D, Lee M, Green N. Effect of Hydroxyurea on Elevated Pulmonary Artery Pressures in Children with Sickle Cell Disease. Blood 2011, 118: 4841. DOI: 10.1182/blood.v118.21.4841.4841.Peer-Reviewed Original ResearchTricuspid regurgitant jet velocityElevated pulmonary artery pressurePulmonary artery pressureSickle cell diseaseArtery pressureCell diseaseEffect of hydroxyureaPulmonary hypertensionElevated tricuspid regurgitant jet velocityWhite blood cell countMean reticulocyte countTotal daily doseRegurgitant jet velocityRole of inflammationMean oxygen saturationBlood cell countFetal hemoglobinMean corpuscular volumeRepeat echocardiogramAverage followEndothelial dysfunctionDaily doseEndothelial functionPersistent elevationMean age
2008
Clinical and molecular characteristics of sickle cell anemia in the northeast of Brazil
Adorno E, Zanette Â, Lyra I, Seixas M, Reis M, Gonçalves M. Clinical and molecular characteristics of sickle cell anemia in the northeast of Brazil. Genetics And Molecular Biology 2008, 31: 621-625. DOI: 10.1590/s1415-47572008000400003.Peer-Reviewed Original ResearchSevere sickle cell anemiaSickle cell anemiaCell anemiaBeta S-globin gene haplotypesMean hemoglobin concentrationLow mean corpuscular volumeMean corpuscular volumeErythrocyte transfusionCerebrovascular accidentHigher mean hemoglobin concentrationHigh HbF levelsClinical dataCAR haplotypeHemoglobin concentrationCorpuscular volumeCorpuscular hemoglobinOutpatientsHbF levelsFetal hemoglobinAnemiaPCR-RFLPCarrier valuesHemoglobinGene haplotypesMolecular characteristics
2006
The Role of Macrophage Migration Inhibitory Factor (MIF) Genetic Polymorphisms in Predicting the Development of Macrocytic Anemia in HIV+ Patients.
Lin S, Fultz S, Justice A, Bucala R, Vanasse K, Berliner N. The Role of Macrophage Migration Inhibitory Factor (MIF) Genetic Polymorphisms in Predicting the Development of Macrocytic Anemia in HIV+ Patients. Blood 2006, 108: 1254. DOI: 10.1182/blood.v108.11.1254.1254.Peer-Reviewed Original ResearchDevelopment of anemiaVeterans Aging Cohort StudySetting of HIVMIF expressionMIF polymorphismsMacrocytic anemiaCox proportional hazards modelMacrophage migration inhibitory factor geneMarkers of morbidityMIF gene polymorphismsEtiology of anemiaIndependent risk factorCo-morbid conditionsCo-morbid diseasesAging Cohort StudySingle nucleotide polymorphismsSeverity of manifestationsRelease of TNFProportional hazards modelCytokine gene expressionMean corpuscular volumeType/severityVariety of illnessesCD4 countCohort studyAre Commonly Ordered Lab Tests Useful Screens for Alcohol Disorders in Older Male Veterans Receiving Primary Care?
Reid MC, Guo Z, Van Ness PH, O'Connor PG, Concato J. Are Commonly Ordered Lab Tests Useful Screens for Alcohol Disorders in Older Male Veterans Receiving Primary Care? Substance Abuse 2006, 26: 25-32. PMID: 16687367, DOI: 10.1300/j465v26n02_04.Peer-Reviewed Original ResearchConceptsAST/ALT ratioAlcohol abuse/dependenceMean corpuscular volumeOlder male veteransAbuse/dependenceAlcohol Use Disorders Identification TestCAGE positivityRisk drinkingAlanine aminotransferaseALT ratioAspartate aminotransferaseAlcohol disordersMale veteransPrimary careMedical recordsParticipants' medical recordsAbnormal test resultsTest performance characteristicsDisorders Identification TestPositive likelihood ratioNegative likelihood ratioLikelihood ratioRoutine careVA databasesCAGE questionnaire
2003
Hematology of a natural population of toque macaques (Macaca sinica) at polonnaruwa, Sri Lanka
Ekanayake D, Horadagoda N, Sanjeevani G, Arulkanthan A, Gunatilake K, Dittus W. Hematology of a natural population of toque macaques (Macaca sinica) at polonnaruwa, Sri Lanka. American Journal Of Primatology 2003, 61: 13-28. PMID: 12966516, DOI: 10.1002/ajp.10105.Peer-Reviewed Original ResearchConceptsToque macaquesErythrocyte sedimentation rateMean corpuscular volumeWild toque macaquesMacaca sinicaDry seasonFree-ranging macaquesRed blood cellsSri LankaStudies of nonhuman primatesMean corpuscular HbSpecies of macaquesNatural populationsSocial groupsHigher mean corpuscular volumeAge classesErythrocyte sedimentation rate valuesAbsolute neutrophil countAbsolute eosinophil countDifferential lymphocyte countsIndex indicators
1987
Screening for alcohol abuse using the cage questionnaire
Bush B, Shaw S, Cleary P, Delbanco T, Aronson M. Screening for alcohol abuse using the cage questionnaire. The American Journal Of Medicine 1987, 82: 231-235. PMID: 2880504, DOI: 10.1016/0002-9343(87)90061-1.Peer-Reviewed Original ResearchConceptsLiver transaminase levelsCAGE questionnaireMean corpuscular volumeAlcohol abuseTransaminase levelsAlcohol abusersCorpuscular volumeScreening testGamma-glutamyl transpeptidase levelsCommunity-based teaching hospitalGamma-glutamyl transpeptidase valuesCAGE-negative patientsDetailed chart reviewMichigan Alcoholism Screening TestAbsence of alcoholismSpecific screening testAlcoholism Screening TestChart reviewRed blood cellsTranspeptidase levelsCAGE questionsProspective studySix-month periodTeaching hospitalPhysician address
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