2023
Correlation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia
Gou M, Li W, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Li C, Zhang P, Huang J, Tian L, Hong L, Tan Y. Correlation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia. Molecular Neurobiology 2023, 61: 2754-2763. PMID: 37932545, DOI: 10.1007/s12035-023-03694-0.Peer-Reviewed Original ResearchImmune-inflammatory response systemWhite matter integrityEnzyme-linked immunosorbent assayDiffusion tensor imagingD effect sizesFractional anisotropyWhole-brain white matter integritySex-matched healthy controlsReflex systemPlasma cytokine levelsFirst-episode patientsBrains of patientsBrain white matter integrityCortico-spinal tractNegative Syndrome ScaleCohen's d effect sizesAverage fractional anisotropyImmune imbalancePeripheral cytokinesCytokine levelsInflammatory mediatorsEpisode patientsPathophysiological mechanismsWhite matter microstructureFunctional dysconnectivity
2021
Mutations in GBA and LRRK2 Are Not Associated with Increased Inflammatory Markers
Thaler A, Omer N, Giladi N, Gurevich T, Bar-Shira A, Gana-Weisz M, Goldstein O, Kestenbaum M, Shirvan J, Cedarbaum J, Orr-Urtreger A, Regev K, Shenhar-Tsarfaty S, Mirelman A. Mutations in GBA and LRRK2 Are Not Associated with Increased Inflammatory Markers. Journal Of Parkinson’s Disease 2021, 11: 1285-1296. PMID: 33998549, PMCID: PMC8461659, DOI: 10.3233/jpd-212624.Peer-Reviewed Original ResearchConceptsNon-manifesting carriersRole of inflammationGBA-PDParkinson's diseaseGenetic Parkinson's diseaseLRRK2-PDPD patientsCerebrospinal fluidNon-manifesting mutation carriersAnti-inflammatory treatmentProdromal Parkinson's diseaseGeneral medical conditionsIdiopathic Parkinson's diseaseLRRK2-PD patientsCSF cytokinesGBA-NMCLRRK2-NMCPeripheral cytokinesInflammatory markersIL-10Inflammatory measuresDisease characteristicsIL-1βIL-6Peripheral blood
2019
Stress‐related suppression of peripheral cytokines predicts future relapse in alcohol‐dependent individuals with and without subclinical depression
Fox HC, Milivojevic V, MacDougall A, LaVallee H, Simpson C, Angarita GA, Sinha R. Stress‐related suppression of peripheral cytokines predicts future relapse in alcohol‐dependent individuals with and without subclinical depression. Addiction Biology 2019, 25: e12832. PMID: 31736187, PMCID: PMC7371343, DOI: 10.1111/adb.12832.Peer-Reviewed Original ResearchConceptsTumor necrosis factor receptor 1Alcohol-dependent individualsInterleukin-6Depressive symptomsStress-related suppressionSubclinical depressionInterleukin-1 receptor antagonistTumor necrosis factor alphaCo-occurring depressive symptomsCo-morbid populationStress-induced suppressionNecrosis factor alphaChronic alcohol abuseAlcohol relapse riskNecrosis factor receptor 1Predictors of relapseHigh depressive symptomatologyFactor receptor 1Peripheral cytokinesCytokine changesCytokine responsesIL-1raSerum measuresReceptor antagonistRelapse risk
2012
H. C. FOX ET AL.
Fox HC, D'Sa C, Kimmerling A, Siedlarz KM, Tuit KL, Stowe R, Sinha R. H. C. FOX ET AL. Human Psychopharmacology Clinical And Experimental 2012, 27: 156-166. PMID: 22389080, PMCID: PMC3674778, DOI: 10.1002/hup.1251.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsIL-10Dependent individualsSocial drinkersInterleukin-1 receptor antagonistTumor necrosis factor alphaElevated inflammatory stateAnti-inflammatory markersNecrosis factor alphaPro-inflammatory TNFαEffects of cocaineImmune system cytokinesChronic stress stateTreatment-seeking cocaine dependent individualsPeripheral cytokinesIL-1raInflammatory stateInterleukin-10Receptor antagonistFactor alphaSignificant elevationNovel biomarkersCocaine dependenceCocaine abusersSalivary cortisol
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