Won Jae Huh, MD, PhD
Assistant Professor of PathologyDownloadHi-Res Photo
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Pathology
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Assistant Professor of Pathology
Biography
Won Jae Huh completed his medical education at the Seoul National University in South Korea. Then he pursued Ph.D. training in Developmental Biology at Washington University in St. Louis. His Ph.D. thesis work with Dr. Jason Mills focused on the transcriptional regulation of gastric chief cell differentiation. Won Jae completed his residency training in Anatomic Pathology at Montefiore Medical Center/Albert Einstein College of Medicine, followed by fellowship in Gastrointestinal and Liver Pathology at Vanderbilt University Medical Center. He did his postdoctoral research training on EGFR and Notch signaling crosstalk in gastric premalignant conditions with Dr. Robert Coffey at Vanderbilt University Medical Center. Won Jae is a recipient of the NIDDK Clinical Scientist Career Development Award. He was an assistant professor at Vanderbilt University Medical Center prior to joining the Department of Pathology at Yale School of Medicine in 2021.
Appointments
Pathology
Assistant ProfessorPrimary
Other Departments & Organizations
- Anatomic Pathology
- Autopsy
- Cancer Signaling Networks
- Huh Lab
- Janeway Society
- Molecular Cell Biology, Genetics and Development
- Molecular Medicine, Pharmacology, and Physiology
- Pathology
- Program in Translational Biomedicine (PTB)
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
- Yale Stem Cell Center
Education & Training
- Postdoctoral fellowship
- Vanderbilt University Medical Center
- Fellowship in GI/Liver Pathology
- Vanderbilt University Medical Center (2016)
- Residency in Anatomic Pathology
- Montefiore Medical Center/Albert Einstein College of Medicine (2014)
- PhD
- Washington University in St. Louis, Developmental Biology (2010)
- BS
- Korea National Open University, Information Statistics
- MD
- Seoul National University College of Medicine (2002)
Research
Overview
Medical Subject Headings (MeSH)
Cell Dedifferentiation; Cell Differentiation; Cell Plasticity; EGF Family of Proteins; Liver; Metaplasia; Stem Cells; Stomach; Stomach Neoplasms
ORCID
0000-0002-6695-5753- View Lab Website
Huh Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Won Jae Huh's published research.
Publications Timeline
A big-picture view of Won Jae Huh's research output by year.
Research Interests
Research topics Won Jae Huh is interested in exploring.
Cindy Khanh Nguyen
Edward Manning, MD, PhD
Francis Lee, MD, PhD, FAAOS, MBA
Hong-Jai Park
Maor Sauler, MD
Min-Jong Kang, MD, PhD, MPH
31Publications
1,717Citations
Stem Cells
Cell Differentiation
Metaplasia
Stomach
Liver
Publications
2024
Arsenic and young liver: a case report of hepatic steatosis due to arsenic toxicity
Nguyen C, Alvarado M, Huh W, Batisti J. Arsenic and young liver: a case report of hepatic steatosis due to arsenic toxicity. Clinical Journal Of Gastroenterology 2024, 1-5. PMID: 39377877, DOI: 10.1007/s12328-024-02045-3.Peer-Reviewed Original ResearchPD-1H/VISTA Agonism Inhibits Host Myeloid Antigen Presenting Cells That Suppresses Acute Graft-Versus-Host Disease without Losing Graft-Versus-Leukemia Effect
Hu Q, Fielder C, Huh W, Kassim A, Kim T. PD-1H/VISTA Agonism Inhibits Host Myeloid Antigen Presenting Cells That Suppresses Acute Graft-Versus-Host Disease without Losing Graft-Versus-Leukemia Effect. Transplantation And Cellular Therapy 2024, 30: s253. DOI: 10.1016/j.jtct.2023.12.336.Peer-Reviewed Original ResearchConceptsMyeloid antigen-presenting cellsHost antigen-presenting cellsAntigen-presenting cellsBone marrow transplantationMyeloid-derived suppressor cellsAllogeneic T cell proliferationAcute GVHDAcute GVHD symptomsGraft-versus-leukemiaPD-1HT cell proliferationHost miceT cellsBMT modelIsotype controlGraft-versus-leukemia (GVLSuppress acute graft-versus-host diseaseMHC-mismatched bone marrow transplantationAcute graft-versus-host diseaseT cell priming phaseGraft-versus-host diseaseMismatched bone marrow transplantationMyeloid antigen presenting cellsAcute GVHD treatmentDonor T cells
2023
VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis.
Kim S, Adams T, Hu Q, Shin H, Chae G, Lee S, Sharma L, Kwon H, Lee F, Park H, Huh W, Manning E, Kaminski N, Sauler M, Chen L, Song J, Kim T, Kang M. VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2023, 69: 22-33. PMID: 36450109, PMCID: PMC10324045, DOI: 10.1165/rcmb.2022-0219oc.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisImmune regulatorsTherapeutic potentialHuman idiopathic pulmonary fibrosisCrucial immune regulatorsNovel immune regulatorPulmonary fibrosis micePulmonary fibrosis modelNovel therapeutic targetRole of VISTAWild-type littermatesMonocyte-derived macrophagesT lymphocyte lineageVISTA expressionIPF treatmentAntibody treatmentImmune landscapeFibrotic mediatorsLung fibrosisFibrosis miceInflammatory responseFibrosis modelMyeloid populationsTherapeutic targetSOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia
Willet S, Thanintorn N, McNeill H, Huh S, Ornitz D, Huh W, Hoft S, DiPaolo R, Mills J. SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia. Cellular And Molecular Gastroenterology And Hepatology 2023, 16: 325-339. PMID: 37270061, PMCID: PMC10444955, DOI: 10.1016/j.jcmgh.2023.05.009.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSRY-box transcription factor 9Cell identityAdult homeostasisGastric progenitorsMucous neck cellsZymogenic chief cellsGastric developmentNeck cellsPotential genesMaster regulatorExpression patternsGene expressionSPEM cellsCell differentiationCorpus unitsSOX9 expressionSOX9Factor 9Specific expansionHomeostasisMisexpressionSox9 deletionReprogrammingChief cellsGenetic deletionIntra-Abdominal Cystic Lymphangiomas: The Vanderbilt Experience
Mede A, Chotai P, Huh W, Tan M. Intra-Abdominal Cystic Lymphangiomas: The Vanderbilt Experience. Journal Of Surgical Research 2023, 285: 197-204. PMID: 36696706, DOI: 10.1016/j.jss.2022.12.026.Peer-Reviewed Case Reports and Technical NotesCitationsMeSH Keywords and ConceptsConceptsAbdominal lymphangiomaSmall bowelExtensive local invasionTime of diagnosisDiagnosis of lymphangiomaInstitutional review boardVanderbilt experienceAbdominal painMultivisceral resectionMedian durationMost patientsClinical featuresFavorable prognosisRetrospective reviewCystic tumorHistopathologic characteristicsInstitution experienceSurgical excisionSymptomatic lesionsMean ageMural nodulesPreoperative imagingRare pathologyExcisional biopsyIncomplete excision
2021
Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps
Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell 2021, 184: 6262-6280.e26. PMID: 34910928, PMCID: PMC8941949, DOI: 10.1016/j.cell.2021.11.031.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdaptive ImmunityAdenomaAdultAgedAnimalsCarcinogenesisCell DeathCell DifferentiationColonic PolypsColorectal NeoplasmsDisease ProgressionFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksGenetic HeterogeneityHumansMaleMiceMiddle AgedMutationNeoplastic Stem CellsReproducibility of ResultsRNA-SeqSingle-Cell AnalysisTumor MicroenvironmentConceptsHuman colorectal polypsColorectal cancerColorectal polypsPrevention of CRCMicrosatellite-unstable colorectal cancersUnstable colorectal cancersGastric metaplasiaImmune microenvironmentTumor cell differentiation statusImmune cellsPrecision surveillancePrecursor polypsSerrated polypsConventional adenomasStem cell propertiesMalignant progressionImmunogenic potentialPolypsTumor cellsTherapeutic insightsCell differentiation statusCellular originMetaplasiaAdenomasMolecular heterogeneitySupermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ. Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets. Nature Cell Biology 2021, 23: 1240-1254. PMID: 34887515, PMCID: PMC8656144, DOI: 10.1038/s41556-021-00805-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSmall extracellular vesiclesTherapeutic targetExtracellular vesiclesHepatic lipidsCardiovascular diseaseCetuximab resistanceMultiple cancersAlzheimer's diseaseDiseaseLactate secretionDisease biomarkersBiomarkersExtracellular RNAIntense investigationHuman diseasesGreater uptakeVivoCancerSecretionCell-Autonomous Role of EGFR in Spontaneous Duodenal Tumors in LRIG1 Null Mice
Niitsu H, Lu Y, Huh W, Love A, Franklin J, Coffey R. Cell-Autonomous Role of EGFR in Spontaneous Duodenal Tumors in LRIG1 Null Mice. Cellular And Molecular Gastroenterology And Hepatology 2021, 12: 1159-1162.e4. PMID: 33989815, PMCID: PMC8413138, DOI: 10.1016/j.jcmgh.2021.05.004.Peer-Reviewed Original ResearchCitationsAltmetric
2020
A smooth muscle‐derived, Braf‐driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell‐of‐origin
Kondo J, Huh WJ, Franklin JL, Heinrich MC, Rubin BP, Coffey RJ. A smooth muscle‐derived, Braf‐driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell‐of‐origin. The Journal Of Pathology 2020, 252: 441-450. PMID: 32944951, PMCID: PMC7802691, DOI: 10.1002/path.5552.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsGastrointestinal stromal tumorsSmooth muscle cellsICC hyperplasiaMuscle cellsTyrosine kinase inhibitor imatinibFrequent driver eventsCommon mesenchymal tumorsSmooth muscle cell progenitorsDevelopment of GISTsKinase inhibitor imatinibLoss of Trp53ICC-DMPGut motilityStromal tumorsMesenchymal tumorsMouse modelInhibitor imatinibInterstitial cellsMutant BRAFBRAF expressionTumorsBRAFHyperplasiaCell progenitorsDriver eventsKey histopathologic features in idiopathic noncirrhotic portal hypertension: an interobserver agreement study and proposal for diagnostic criteria
Liang J, Shi C, Dupont WD, Salaria SN, Huh WJ, Correa H, Roland JT, Perri RE, Washington MK. Key histopathologic features in idiopathic noncirrhotic portal hypertension: an interobserver agreement study and proposal for diagnostic criteria. Modern Pathology 2020, 34: 592-602. PMID: 32958831, DOI: 10.1038/s41379-020-00676-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIdiopathic noncirrhotic portal hypertensionObliterative portal venopathyNoncirrhotic portal hypertensionPortal hypertensionLiver biopsyDiagnostic criteriaInterobserver agreement studyHistologic featuresHistopathologic diagnostic criteriaOriginal pathologic diagnosisPractical diagnostic criteriaAgreement studyKey histopathologicPortal venopathyVein sclerosisHistologic predictorsClinicopathologic correlationHistologic diagnosisPathologic diagnosisHistologic assessmentExperienced hepatopathologistsClinical informationHypertensionBiopsyThree-tiered classification
Clinical Care
Overview
Clinical Specialties
Pathology; GI & Liver Pathology
Board Certifications
Anatomic Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 2014
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News
- July 22, 2022
Huh Lab Welcomes Newest Postdoctoral Associate, Miyoung Shin, PhD
- April 19, 2022
Tryston Gabriel, New Postgraduate Associate in Huh Lab
- April 12, 2022
Yale Pathology Meets in Madison for Department Retreat; First In-Person Gathering Since Pandemic Began
- January 17, 2022
Huh Lab Seeks Applicants for Postdoctoral, Postgraduate Associate Positions
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Brady Memorial Laboratory
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310 Cedar Street, Rm BML 142
New Haven, CT 06510
Lauder Hall
Academic Office
310 Cedar Street, Rm LH 219A
New Haven, CT 06510
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203.785.7308Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.