Tristan Geiller, PhD
Assistant ProfessorCards
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Research
Publications
2025
Visually guided in vivo single-cell electroporation for monitoring and manipulating mammalian hippocampal neurons
Gonzalez K, Noguchi A, Zakka G, Yong H, Terada S, Szoboszlay M, O’Hare J, Negrean A, Geiller T, Polleux F, Losonczy A. Visually guided in vivo single-cell electroporation for monitoring and manipulating mammalian hippocampal neurons. Nature Protocols 2025, 20: 1468-1484. PMID: 39930062, PMCID: PMC12151752, DOI: 10.1038/s41596-024-01099-4.Peer-Reviewed Original Research
2023
Inhibitory control of sharp-wave ripple duration during learning in hippocampal recurrent networks
Vancura B, Geiller T, Grosmark A, Zhao V, Losonczy A. Inhibitory control of sharp-wave ripple duration during learning in hippocampal recurrent networks. Nature Neuroscience 2023, 26: 788-797. PMID: 37081295, PMCID: PMC10209669, DOI: 10.1038/s41593-023-01306-7.Peer-Reviewed Original ResearchConceptsSharp-wave ripplesInterneuron activityPopulation of inhibitory interneuronsRecurrent excitatory connectionsMemory consolidationRegion-specific rolesHippocampal-dependent learningInhibitory controlLearning-related plasticityInhibitory interneuronsInhibitory circuitsCalcium imagingCell activationExcitatory connectionsMouse hippocampusRegion-specific responsesHippocampal region CA3Electrophysiological oscillationsRegion CA3HippocampalRecurrent circuitsRipple durationCA3Subtype-Ca2A local circuit-basis for spatial navigation and memory processes in hippocampal area CA1
Geiller T, Priestley J, Losonczy A. A local circuit-basis for spatial navigation and memory processes in hippocampal area CA1. Current Opinion In Neurobiology 2023, 79: 102701. PMID: 36878147, PMCID: PMC10020891, DOI: 10.1016/j.conb.2023.102701.Peer-Reviewed Original ResearchConceptsExcitatory neuronsPlasticity rulesLocal computationMemory formationSerial operationsOutput nodesHippocampal area CA1Ensemble codingFeedforward processingDynamic repertoireInhibitory microcircuitsArea CA1CA1 areaMemory encodingMemory processesLocal circuitryCA1Spatial navigationNeuronsLocal interactionsCircuit basisMemoryHippocampusEncodingHippocampal
2022
Compartment-specific tuning of dendritic feature selectivity by intracellular Ca2+ release
O'Hare J, Gonzalez K, Herrlinger S, Hirabayashi Y, Hewitt V, Blockus H, Szoboszlay M, Rolotti S, Geiller T, Negrean A, Chelur V, Polleux F, Losonczy A. Compartment-specific tuning of dendritic feature selectivity by intracellular Ca2+ release. Science 2022, 375: eabm1670. PMID: 35298275, PMCID: PMC9667905, DOI: 10.1126/science.abm1670.Peer-Reviewed Original ResearchConceptsIntracellular calcium releaseDendritic calcium signalsMammalian neurons in vivoNeurons in vivoIntracellular Ca2Calcium releaseBasal dendritesCalcium signalingNeural plasticity mechanismsCompartment-specific mannerIn vivoSomatic activityEndoplasmic reticulumPlasticity mechanismsReleaseReceptive fieldsNeuronsLocal feedback inhibition tightly controls rapid formation of hippocampal place fields
Rolotti S, Ahmed M, Szoboszlay M, Geiller T, Negrean A, Blockus H, Gonzalez K, Sparks F, Solis Canales A, Tuttman A, Peterka D, Zemelman B, Polleux F, Losonczy A. Local feedback inhibition tightly controls rapid formation of hippocampal place fields. Neuron 2022, 110: 783-794.e6. PMID: 34990571, PMCID: PMC8897257, DOI: 10.1016/j.neuron.2021.12.003.Peer-Reviewed Original Research
2021
Adaptive stimulus selection for consolidation in the hippocampus
Terada S, Geiller T, Liao Z, O’Hare J, Vancura B, Losonczy A. Adaptive stimulus selection for consolidation in the hippocampus. Nature 2021, 601: 240-244. PMID: 34880499, PMCID: PMC9380538, DOI: 10.1038/s41586-021-04118-6.Peer-Reviewed Original ResearchConceptsTwo-photon calcium imagingSensory stimuliBehavioral adaptationsSimultaneous local field potential recordingsLocal field potential recordingsField potential recordingsMemory acquisitionAssociative learningMemory consolidationProjections to CA1Stimulus selectionNeural circuitsMemory replayReplay eventsHippocampusSensory cuesSensory featuresAssociative memoryMemoryCA3 projectionsSensory environmentPotential recordingsStimuliSensory experienceSpatial locationLocal circuit amplification of spatial selectivity in the hippocampus
Geiller T, Sadeh S, Rolotti S, Blockus H, Vancura B, Negrean A, Murray A, Rózsa B, Polleux F, Clopath C, Losonczy A. Local circuit amplification of spatial selectivity in the hippocampus. Nature 2021, 601: 105-109. PMID: 34853473, PMCID: PMC9746172, DOI: 10.1038/s41586-021-04169-9.Peer-Reviewed Original ResearchRecruitment and inhibitory action of hippocampal axo-axonic cells during behavior
Dudok B, Szoboszlay M, Paul A, Klein P, Liao Z, Hwaun E, Szabo G, Geiller T, Vancura B, Wang B, McKenzie S, Homidan J, Klaver L, English D, Huang Z, Buzsáki G, Losonczy A, Soltesz I. Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior. Neuron 2021, 109: 3838-3850.e8. PMID: 34648750, PMCID: PMC8639676, DOI: 10.1016/j.neuron.2021.09.033.Peer-Reviewed Original ResearchConceptsAxo-axonic cellsPyramidal cellsInhibitory controlOptogenetic inhibitionCellular sourceInhibitory actionCA1 pyramidal cellsEffects of GABAHippocampal pyramidal cellsHead-restrained miceAction potential generationPyramidal cell place fieldsHippocampal area CA1Random foraging taskSource of GABAAxon initial segmentCell's place fieldGABAergic controlArea CA1Episodes of locomotionCortical circuitsPotential generationForaging taskCA1GABA
2020
Large-Scale 3D Two-Photon Imaging of Molecularly Identified CA1 Interneuron Dynamics in Behaving Mice
Geiller T, Vancura B, Terada S, Troullinou E, Chavlis S, Tsagkatakis G, Tsakalides P, Ócsai K, Poirazi P, Rózsa B, Losonczy A. Large-Scale 3D Two-Photon Imaging of Molecularly Identified CA1 Interneuron Dynamics in Behaving Mice. Neuron 2020, 108: 968-983.e9. PMID: 33022227, PMCID: PMC7736348, DOI: 10.1016/j.neuron.2020.09.013.Peer-Reviewed Original ResearchConceptsDiversity of GABAergic interneuronsClasses of interneuronsLocal inhibitory circuitsHippocampal area CA1Feature selectionGABAergic interneuronsMouse hippocampal area CA1GABAergic cellsArea CA1Inhibitory circuitsBehaving miceCortical computationInterneuron classesTwo-photon imagingGoal-directed learningLocal circuitsBehaving animalsInterneuronsCA1MiceHippocampusMnemonic functionsBehavioral tasksResponse propertiesA Role for the Locus Coeruleus in Hippocampal CA1 Place Cell Reorganization during Spatial Reward Learning
Kaufman A, Geiller T, Losonczy A. A Role for the Locus Coeruleus in Hippocampal CA1 Place Cell Reorganization during Spatial Reward Learning. Neuron 2020, 105: 1018-1026.e4. PMID: 31980319, PMCID: PMC7265133, DOI: 10.1016/j.neuron.2019.12.029.Peer-Reviewed Original ResearchConceptsLocus coeruleusSpatial learning taskCell reorganizationReward learningDorsal hippocampalCA1 place cellsBehavioral performanceSpatial learningHippocampal placeDegree of overrepresentationCircuit mechanismsLearning tasksNeuromodulatory actionsTwo-photon calcium imagingHippocampalArea CA1Optogenetic stimulationGoal locationRewardPlace cellsLoci
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Apr 20266Monday
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