Trevor Sorrells, PhD
Cards
Appointments
Contact Info
Yale School of Medicine
PO Box 208005
New Haven, CT 06520-8005
United States
About
Titles
Assistant Professor of Genetics
Biography
Trevor Sorrells received his B.S. in Biology from Stanford University in 2009. He completed his PhD in the lab of Alexander Johnson at the University of California, San Francisco where he pioneered molecular biological and genomic approaches in non-model yeast species to understand how transcription regulatory networks evolve. This work provided a mechanistic understanding of how network architecture and molecular function dictate the ways in which biological systems change over time. As a postdoctoral fellow with Leslie Vosshall at Rockefeller University, Trevor discovered a persistent behavioral state in the mosquito Aedes aegypti that sustains their pursuit of humans over time. To do this, he introduced optogenetics to study the brain of this important vector of disease. The Sorrells lab studies the neural circuits that control the ability of mosquitoes to bite humans and how this behavior evolved from their non-biting ancestors.
Appointments
Genetics
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Fellow
- Rockefeller University (2022)
- PhD
- University of California, San Francisco (2016)
- BS
- Stanford University (2009)
Research
Overview
Medical Research Interests
ORCID
0000-0002-3527-8622- View Lab Website
Sorrells Lab
Research at a Glance
Publications Timeline
Research Interests
Gene Regulatory Networks
Behavior, Animal
Biological Evolution
Publications
2022
A persistent behavioral state enables sustained predation of humans by mosquitoes
Sorrells T, Pandey A, Rosas-Villegas A, Vosshall L. A persistent behavioral state enables sustained predation of humans by mosquitoes. ELife 2022, 11: e76663. PMID: 35550041, PMCID: PMC9154740, DOI: 10.7554/elife.76663.Peer-Reviewed Original ResearchCitationsAltmetric
2020
Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes
Jové V, Gong Z, Hol F, Zhao Z, Sorrells T, Carroll T, Prakash M, McBride C, Vosshall L. Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes. Neuron 2020, 108: 1163-1180.e12. PMID: 33049200, PMCID: PMC9831381, DOI: 10.1016/j.neuron.2020.09.019.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBlood componentsSpecific blood componentsBlood-feeding mosquitoesAdditional blood componentsAedes aegypti mosquitoesAedes aegypti femalesCalcium imagingNeuron classesBloodMeal sizeSpecialized neuronsAegypti mosquitoesMetabolic fateMillions of peopleAegypti femalesBlood mealSensory discriminationDisease transmissionFeeding programsNeuronsSensory detectionMosquitoesTaste qualityVector-borne disease transmissionMealProtein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit
Britton C, Sorrells T, Johnson A. Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit. Science 2020, 367: 96-100. PMID: 31896718, PMCID: PMC8284397, DOI: 10.1126/science.aax5217.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2018
Intrinsic cooperativity potentiates parallel cis-regulatory evolution
Sorrells T, Johnson A, Howard C, Britton C, Fowler K, Feigerle J, Weil P, Johnson A. Intrinsic cooperativity potentiates parallel cis-regulatory evolution. ELife 2018, 7: e37563. PMID: 30198843, PMCID: PMC6173580, DOI: 10.7554/elife.37563.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRegulatory sequencesGeneral transcription factor TFIIDCis-regulatory evolutionRibosomal protein genesTranscription factor TFIIDCommon interaction partnersFungal lineagesAncestral regulatorFactor TFIIDIndependent lineagesEvolutionary eventsGenomic scaleTranscription regulatorsTranscriptional activationParallel evolutionProtein geneRegulatory proteinsSecond regulatorInteraction partnersRandom mutationsFunctional sitesIntrinsic cooperativityMcm1Rap1Regulator
2015
Intersecting transcription networks constrain gene regulatory evolution
Sorrells T, Booth L, Tuch B, Johnson A. Intersecting transcription networks constrain gene regulatory evolution. Nature 2015, 523: 361-365. PMID: 26153861, PMCID: PMC4531262, DOI: 10.1038/nature14613.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsBase SequenceBinding SitesDNA, FungalDNA-Binding ProteinsEnhancer Elements, GeneticEpistasis, GeneticEvolution, MolecularGene Expression Regulation, FungalGene Regulatory NetworksGenes, FungalKluyveromycesMating FactorPeptidesPheromonesPromoter Regions, GeneticSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsConceptsGene regulatory evolutionGene regulatory networksRegulatory DNARegulatory evolutionTranscription networksCommon ancestorRegulatory networksEpistatic interactionsSpecific genesSingle proteinMutation effectsSecond pathwayCandida albicansSuch interactionsSpecific changesSaccharomycesAncestorGenesEvolutionRegulatorProteinDNAMutationsPathwayInteractionMaking Sense of Transcription Networks
Sorrells T, Johnson A. Making Sense of Transcription Networks. Cell 2015, 161: 714-723. PMID: 25957680, PMCID: PMC4531093, DOI: 10.1016/j.cell.2015.04.014.Peer-Reviewed Original ResearchCitationsMeSH Keywords and Concepts
2013
Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains
Lohse M, Hernday A, Fordyce P, Noiman L, Sorrells T, Hanson-Smith V, Nobile C, DeRisi J, Johnson A. Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 7660-7665. PMID: 23610392, PMCID: PMC3651432, DOI: 10.1073/pnas.1221734110.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsCandida albicansChromatin ImmunoprecipitationComputational BiologyDNADNA-Binding ProteinsFungal ProteinsGene DeletionGene Expression ProfilingGene Expression Regulation, FungalGreen Fluorescent ProteinsMultigene FamilyProtein BindingProtein Interaction Domains and MotifsTranscription, GeneticConceptsSequence-specific DNA-binding proteinsDNA-binding domainWhite-opaque switchingDNA-binding proteinsTranscriptional regulatorsOpaque cellsGenome-wide chromatin immunoprecipitationHuman fungal pathogen Candida albicansSequence-specific DNA-binding domainFungal pathogen Candida albicansHeritable cell typesCis-regulatory sequencesGene regulatory proteinsRNA-binding proteinFraction of genesMajor fungal pathogenPathogen Candida albicansDeletion mutant strainAspects of biologySequence-specific mannerGene expression profilingDeep conservationCurrent annotationEvolutionary timeSmall clade
2012
Protein Modularity, Cooperative Binding, and Hybrid Regulatory States Underlie Transcriptional Network Diversification
Baker C, Booth L, Sorrells T, Johnson A. Protein Modularity, Cooperative Binding, and Hybrid Regulatory States Underlie Transcriptional Network Diversification. Cell 2012, 151: 80-95. PMID: 23021217, PMCID: PMC3519278, DOI: 10.1016/j.cell.2012.08.018.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsProtein modularityAncestral modeConserved expression patternCis-regulatory sequencesNovel regulatory modeProtein-DNA interactionsRegulatory network structureMode of regulationTranscription regulationAncestral networksGene regulationModern speciesDifferent lineagesYeast speciesExpression patternsRegulatory stateRegulatory modeCooperative bindingType cellsRegulationSpeciesLineagesGenesDiversityDiversificationA Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans
Nobile C, Fox E, Nett J, Sorrells T, Mitrovich Q, Hernday A, Tuch B, Andes D, Johnson A. A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans. Cell 2012, 148: 126-138. PMID: 22265407, PMCID: PMC3266547, DOI: 10.1016/j.cell.2011.10.048.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsBiofilmsCandida albicansCandidiasis, OralCandidiasis, VulvovaginalCatheter-Related InfectionsDisease Models, AnimalEvolution, MolecularFemaleGene Expression ProfilingGene Expression Regulation, FungalGene Regulatory NetworksGenes, FungalMaleMicroscopy, ConfocalRatsRats, Sprague-DawleyStomatitis, DentureConceptsBiofilm formationPathogenic yeast Candida albicansGenome-wide approachesComplex cell behaviorsAncient genesYeast Candida albicansGenetic screenTranscriptional networksEvolutionary analysisTranscription regulatorsTranscription circuitsMammalian hostsTarget genesBiofilm networksBiofilm developmentCandida albicansGenesCell behaviorIndividual cellsSuspension culturesMedical device-associated infectionsDrug resistanceBiofilmsMicrobesRegulator
2011
Chemical Defense by the Native Winter Ant (Prenolepis imparis) against the Invasive Argentine Ant (Linepithema humile)
Sorrells T, Kuritzky L, Kauhanen P, Fitzgerald K, Sturgis S, Chen J, Dijamco C, Basurto K, Gordon D. Chemical Defense by the Native Winter Ant (Prenolepis imparis) against the Invasive Argentine Ant (Linepithema humile). PLOS ONE 2011, 6: e18717. PMID: 21526231, PMCID: PMC3079705, DOI: 10.1371/journal.pone.0018717.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
Academic Achievements & Community Involvement
honor HHMI Freeman Hrabowski Scholar
National AwardHoward Hughes Medical InstituteDetails09/01/2023honor NIAID New Innovator Award
National AwardNational Institutes of HealthDetails08/01/2023honor Bohmfalk Scholar
Yale School of Medicine AwardYale School of MedicineDetails05/26/2023United Stateshonor Polak Young Investigator Award
International AwardAssociation for Chemoreception SciencesDetails04/20/2022United Stateshonor Harold M. Weintraub Award
International AwardFred Hutchinson Cancer CenterDetails05/01/2016
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Yale School of Medicine
PO Box 208005
New Haven, CT 06520-8005
United States