Michael O'Donnell
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About
Titles
Assistant Professor in Molecular, Cellular and Developmental Biology
Appointments
Molecular, Cellular, and Developmental Biology
Assistant ProfessorPrimary
Other Departments & Organizations
Research
Publications
2022
Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in Caenorhabditiselegans
Kyani-Rogers T, Philbrook A, McLachlan I, Flavell S, O’Donnell M, Sengupta P. Developmental history modulates adult olfactory behavioral preferences via regulation of chemoreceptor expression in Caenorhabditiselegans. Genetics 2022, 222: iyac143. PMID: 36094348, PMCID: PMC9630977, DOI: 10.1093/genetics/iyac143.Peer-Reviewed Original ResearchConceptsChemoreceptor genesDAF-16 FOXO transcription factorODR-10FOXO transcription factorsDistinct gene expression profilesGene expression profilesDauer arrestChemoreceptor expressionDauer stageAWA neuronsDauer larvaeC. elegansTranscription factorsTranscriptional profilingBehavioral plasticityPosttranscriptional mechanismsTranscriptional upregulationAdult physiologyExpression patternsExpression profilesSorted populationsBehavioral preferencesVolatile odorantsCaenorhabditiselegansReceptor regulationContext-dependent reversal of odorant preference is driven by inversion of the response in a single sensory neuron type
Khan M, Hartmann A, O’Donnell M, Piccione M, Pandey A, Chao P, Dwyer N, Bargmann C, Sengupta P. Context-dependent reversal of odorant preference is driven by inversion of the response in a single sensory neuron type. PLOS Biology 2022, 20: e3001677. PMID: 35696430, PMCID: PMC9232122, DOI: 10.1371/journal.pbio.3001677.Peer-Reviewed Original Research
2021
Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival
Wrobel C, Yu J, Rodrigues P, Ludewig A, Curtis B, Cohen S, Fox B, O’Donnell M, Sternberg P, Schroeder F. Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival. Journal Of The American Chemical Society 2021, 143: 14676-14683. PMID: 34460264, PMCID: PMC8594405, DOI: 10.1021/jacs.1c05908.Peer-Reviewed Original ResearchConceptsStarvation conditionsCombinatorial assemblyPremier model systemRelated nematode speciesModel organismsStarvation survivalClose homologueGenome editingBiosynthetic roleNematode speciesBiological functionsComparative metabolomicsDeletion resultsAmino acidsFirst insightModel systemMetabolite libraryLipid metabolismAdult animalsAssemblyCRISPRBiosynthesisHomologuesDularOrganisms
2020
A neurotransmitter produced by gut bacteria modulates host sensory behaviour
O’Donnell M, Fox B, Chao P, Schroeder F, Sengupta P. A neurotransmitter produced by gut bacteria modulates host sensory behaviour. Nature 2020, 583: 415-420. PMID: 32555456, PMCID: PMC7853625, DOI: 10.1038/s41586-020-2395-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvoidance LearningCaenorhabditis elegansCaenorhabditis elegans ProteinsFeeding BehaviorGastrointestinal MicrobiomeIntestinesMetabolomicsMutationNeurotransmitter AgentsOctanolsOctopamineProvidenciaReceptors, Biogenic AmineReceptors, G-Protein-CoupledSensory Receptor CellsSmellTyramineTyrosine DecarboxylaseConceptsTyramine biosynthesisFood choice assaysASH nociceptive neuronsDiverse organismsCaenorhabditis elegansMutualistic relationshipComplex communitiesChoice assaysMechanistic basisHost behaviourOlfactory responsesPhysiological relevanceOctopamine receptorsGut bacteriaElegansBioactive neurotransmittersBacteriaBiosynthesisHost controlGenesNervous system activitySensory behaviorsOctopamineNociceptive neuronsProvidencia
2018
Thermosensation: Human Parasitic Nematodes Use Heat to Hunt Hosts
O’Donnell M, Khan M, Sengupta P. Thermosensation: Human Parasitic Nematodes Use Heat to Hunt Hosts. Current Biology 2018, 28: r795-r798. PMID: 30040942, DOI: 10.1016/j.cub.2018.05.082.Peer-Reviewed Original ResearchRictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans
O’Donnell M, Chao P, Kammenga J, Sengupta P. Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans. PLOS Genetics 2018, 14: e1007213. PMID: 29415022, PMCID: PMC5819832, DOI: 10.1371/journal.pgen.1007213.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsAnimals, Genetically ModifiedBrainCaenorhabditis elegansCaenorhabditis elegans ProteinsGene Expression Regulation, DevelopmentalIntestinal MucosaIntestinesMechanistic Target of Rapamycin Complex 2Neuronal PlasticityPhenotypeRapamycin-Insensitive Companion of mTOR ProteinSensory Receptor CellsSignal TransductionTemperatureConceptsQuantitative trait lociDauer larval stageTarget of rapamycinNematode C. elegansExternal cuesInsulin-like peptidesNeuronal functionDAF-7Phenotypic plasticityDaf-28Developmental decisionsC. elegansTrait lociCellular stressorsBacterial foodGenetic variationForaging behaviorRictor/Reproductive growthLarval developmentEnvironmental cuesNeuroendocrine gene expressionGene expressionLarval stagesFood signals
2015
Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling
Neal S, Takeishi A, O'Donnell M, Park J, Hong M, Butcher R, Kim K, Sengupta P. Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling. ELife 2015, 4: e10110. PMID: 26335407, PMCID: PMC4558564, DOI: 10.7554/elife.10110.Peer-Reviewed Original ResearchConceptsNeuroendocrine signalingDevelopmental plasticityInsulin-like peptide genesDynamic subcellular localizationDauer decisionDauer formationILP genesDauer stageDevelopmental decisionsSubcellular localizationNutrient availabilityState-dependent regulationPeptide genesReproductive cycleUnknown mechanismCaMKICMK-1SignalingGenesSensory neuronsPlasticityExpressionAWCCaenorhabditisSmall neuronal networks
2013
Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits
O’Donnell M, Bashaw G. Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits. Development 2013, 140: 2724-2733. PMID: 23720041, PMCID: PMC3678342, DOI: 10.1242/dev.093831.Peer-Reviewed Original ResearchConceptsFunctional domainsC-terminal F-actinGuidance pathwayMidline axon crossingDistinct functional domainsAbelson tyrosine kinaseFunctional nervous systemKinase-dependent inhibitionAbl C-terminusGenetic screenMultifunctional kinaseMotor axonsNervous systemDistinct structural motifsNon-overlapping setsGuidance ligandsNeural circuitsSignaling cascadesC-terminusMidline attractionTyrosine kinaseF-actinAxon crossingAxon guidanceGuidance responsesSrc Inhibits Midline Axon Crossing Independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) Receptor Tyrosine Phosphorylation
O'Donnell M, Bashaw G. Src Inhibits Midline Axon Crossing Independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) Receptor Tyrosine Phosphorylation. Journal Of Neuroscience 2013, 33: 305-314. PMID: 23283343, PMCID: PMC3739878, DOI: 10.1523/jneurosci.2756-12.2013.Peer-Reviewed Original ResearchConceptsSrc kinaseMidline axonsTyrosine phosphorylationSrc family kinasesDrosophila embryonic CNSReceptor tyrosine phosphorylationCommissural axonsDrosophila orthologUnexpected functionFamily kinasesEmbryonic CNSDownstream effectorsMidline attractionNetrin receptor DCCKinaseNetrin familyNovel mechanismAttractive turningPhosphorylationEffectorsReceptor DCCOrthologsCommissural neuronsVertebratesFrazzled
2009
Axon Growth and Guidance: Receptor Regulation and Signal Transduction
O'Donnell M, Chance R, Bashaw G. Axon Growth and Guidance: Receptor Regulation and Signal Transduction. Annual Review Of Neuroscience 2009, 32: 383-412. PMID: 19400716, PMCID: PMC4765433, DOI: 10.1146/annurev.neuro.051508.135614.Peer-Reviewed Original ResearchConceptsNeural developmental disordersReceptor regulationGrowth cone cytoskeletonAxon growthGrowth cone guidanceSignal transductionGuidance receptorsPathway functionWiring specificityRegulated actionGuidance cuesNervous systemNeuronal receptorsRegulationReceptorsRecent advancesCytoskeletonTransductionConsiderable progressDevelopmental disordersGrowthTemporal distributionMechanismConnectivity patternsFamily