Julien Berro, PhD
Associate Professor of Molecular Biophysics and Biochemistry, and of Cell BiologyDownloadHi-Res Photo
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Cell Biology
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Associate Professor of Molecular Biophysics and Biochemistry, and of Cell Biology
Biography
Julien Berro was initially trained in Applied Mathematics, Physics and Computer Sciences at the Institut National Polytechnique of Grenoble, France. He obtained his Ph.D. in Mathematical Modeling in Biology at Université Joseph Fourier, Grenoble, France, where he worked with Jean-Louis Martiel and Laurent Blanchoin on mathematical models for actin filament biochemistry and mechanics. After a brief tenure as an assistant professor in the department of Mathematics at Université Claude Bernard, Lyon, France, he decided to further his training by learning cell biology and quantitative microscopy in the laboratory of Tom Pollard at Yale University. Since he started his own laboratory in 2013, he has combined experimental, computational, and theoretical approaches to uncover the mechanisms of molecular machineries that produce forces in the cell, with a particular focus on the actin cytoskeleton and endocytosis.
Appointments
Molecular Biophysics and Biochemistry
Associate Professor on TermPrimaryCell Biology
Associate Professor on TermSecondary
Other Departments & Organizations
- Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS)
- Cell Biology
- Center for Biomedical Data Science
- Computational Biology and Biomedical Informatics
- Cytoskeletal Dynamics
- Membrane Traffic
- Molecular Biophysics and Biochemistry
- Molecular Cell Biology, Genetics and Development
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Ventures
Education & Training
- Postdoc
- Yale University (2013)
- PhD
- Universite Joseph Fourier (2006)
- MSc
- École Nationale Supérieure d'Informatique et de Mathématiques Appliquées (ENSIMAG/INP-Grenoble, France), Applied Mathematics and Computer Sciences (2003)
- AS
- Universite Pierre et Marie Curie (2000)
Research
Overview
Medical Research Interests
Biophysics; Cell Biology; Cytoskeleton; Endocytosis; Kinetics; Machine Learning; Mathematical Concepts; Mechanics; Microscopy; Microscopy, Confocal; Microscopy, Fluorescence; Models, Theoretical; Nonlinear Dynamics; Schizosaccharomyces; Single Molecule Imaging; Systems Biology
ORCID
0000-0002-9560-8646- View Lab Website
The Berro lab website
Research at a Glance
Yale Co-Authors
Frequent collaborators of Julien Berro's published research.
Publications Timeline
A big-picture view of Julien Berro's research output by year.
Research Interests
Research topics Julien Berro is interested in exploring.
Yuan Ren, PhD
Yongli Zhang, PhD, MS
Thomas Pollard, MD
19Publications
607Citations
Endocytosis
Schizosaccharomyces
Microscopy, Fluorescence
Kinetics
Cytoskeleton
Publications
2024
Fast Fission Yeast Genome Editing by CRISPR/Cas9 Using Gap Repair and Fluoride Selection
Ren Y, Fernandez R, Saito T, Fujita B, Mousavi I, Berro J. Fast Fission Yeast Genome Editing by CRISPR/Cas9 Using Gap Repair and Fluoride Selection. Methods In Molecular Biology 2024, 2862: 141-154. PMID: 39527198, DOI: 10.1007/978-1-0716-4168-2_10.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsCross-regulations of two connected domains form a mechanical circuit for steady force transmission during clathrin-mediated endocytosis
Ren Y, Yang J, Fujita B, Zhang Y, Berro J. Cross-regulations of two connected domains form a mechanical circuit for steady force transmission during clathrin-mediated endocytosis. Cell Reports 2024, 43: 114725. PMID: 39276354, PMCID: PMC11476202, DOI: 10.1016/j.celrep.2024.114725.Peer-Reviewed Original ResearchConceptsClathrin-mediated endocytosisF-actinActin cytoskeletonFission yeast Schizosaccharomyces pombeYeast Schizosaccharomyces pombeCell adhesion complexAdhesion complexesMembrane localizationPN forcesStable bindingEnd4pCross-regulationCytoskeletonActinEndocytosisMembraneBindingMechanical forcesTalinTransmission of forcesThatchForce transmissionDomainCellsFissionCRISPR-Cas9 editing efficiency in fission yeast is not limited by homology search and is improved by combining gap-repair with fluoride selection
Fernandez R, Berro J. CRISPR-Cas9 editing efficiency in fission yeast is not limited by homology search and is improved by combining gap-repair with fluoride selection. MicroPublication Biology 2024, 2024: 10.17912/micropub.biology.001191. PMID: 38778900, PMCID: PMC11109758, DOI: 10.17912/micropub.biology.001191.Peer-Reviewed Original ResearchCitationsAltmetricConceptsFission yeastEditing efficiencyHomology searchHomologous recombinational repair machineryDonor DNACRISPR-Cas9 protocolImprove editing efficiencyCRISPR-Cas9 editingModel organismsSelectable markerCut siteYeastGenome editingRepair machineryGap repairGenomeHomologyDNAEditing sequenceFissionLociHaloTagProteinSequenceMachineryIn vivo force measurements on formin Cdc12p using new coiled-coil force sensors
Saito T, Ren Y, Berro J. In vivo force measurements on formin Cdc12p using new coiled-coil force sensors. Biophysical Journal 2024, 123: 465a. DOI: 10.1016/j.bpj.2023.11.2817.Peer-Reviewed Original Research
2023
Force redistribution in clathrin-mediated endocytosis revealed by coiled-coil force sensors
Ren Y, Yang J, Fujita B, Jin H, Zhang Y, Berro J. Force redistribution in clathrin-mediated endocytosis revealed by coiled-coil force sensors. Science Advances 2023, 9: eadi1535. PMID: 37831774, PMCID: PMC10575576, DOI: 10.1126/sciadv.adi1535.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsActin cytoskeletonPlasma membraneHuntingtin Interacting Protein 1Clathrin-mediated endocytosisCountless cellular processesEndocytic machineryCellular processesClathrin latticesProtein condensationCytoskeletonEnd4pProtein 1Membrane deformationPiconewton forcesEndocytosisVivo force measurementsMembranePiconewtonsClathrinMachineryProteinCoatMolecular scale2A peptide from ERBV-1 efficiently separates endogenous protein domains in the fission yeast Schizosaccharomyces pombe
Ren Y, Lin Q, Berro J. 2A peptide from ERBV-1 efficiently separates endogenous protein domains in the fission yeast Schizosaccharomyces pombe. MicroPublication Biology 2023, 2023: 10.17912/micropub.biology.000941. PMID: 37767365, PMCID: PMC10520729, DOI: 10.17912/micropub.biology.000941.Peer-Reviewed Original ResearchCitationsAltmetricConcepts
2019
Crosslinking actin networks produces compressive force
Ma R, Berro J. Crosslinking actin networks produces compressive force. Cytoskeleton 2019, 76: 346-354. PMID: 31278856, PMCID: PMC7001507, DOI: 10.1002/cm.21552.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2018
“Essentially, all models are wrong, but some are useful”—a cross-disciplinary agenda for building useful models in cell biology and biophysics
Berro J. “Essentially, all models are wrong, but some are useful”—a cross-disciplinary agenda for building useful models in cell biology and biophysics. Biophysical Reviews 2018, 10: 1637-1647. PMID: 30421276, PMCID: PMC6297095, DOI: 10.1007/s12551-018-0478-4.Peer-Reviewed Original ResearchCitationsAltmetricMolecular mechanisms of force production in clathrin‐mediated endocytosis
Lacy MM, Ma R, Ravindra NG, Berro J. Molecular mechanisms of force production in clathrin‐mediated endocytosis. FEBS Letters 2018, 592: 3586-3605. PMID: 30006986, PMCID: PMC6231980, DOI: 10.1002/1873-3468.13192.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsQuantitative Biology of Endocytosis
Berro J, Lacy M. Quantitative Biology of Endocytosis. Colloquium Series On Quantitative Cell Biology 2018, 4: i-74. DOI: 10.4199/c00164ed1v01y201805qcb004.BooksCitationsAltmetric
Academic Achievements & Community Involvement
honor Postdoctoral Fellowship
International AwardEMBO (European Molecular Biology Organisation)Details11/28/2007United States
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