Jorge Sepulcre, MD, PhD
Associate Professor of Radiology and Biomedical ImagingCards
About
Research
Publications
2025
Sex and APOE status moderate locus coeruleus network related resilience in preclinical Alzheimer's disease
Lawn T, Diez I, Bueichekú2 E, Van Egroo M, Coughlan G, Buckley R, Rentz D, Johnson K, Sperling R, Sepulcre J, Jacobs H. Sex and APOE status moderate locus coeruleus network related resilience in preclinical Alzheimer's disease. Alzheimer's & Dementia 2025, 21: e107257. PMCID: PMC12791154, DOI: 10.1002/alz70856_107257.Peer-Reviewed Original ResearchAlzheimer's diseasePreclinical Alzheimer Cognitive CompositeLC-FCLocus coeruleusCognitive resilienceCognitive declineAPOE-e4 carriersTask-positiveTau pathologyFrontoparietal control networkResting-state fMRIBrain network architectureAssociated with resiliencePreclinical Alzheimer's diseaseFalse-discovery rate correctionGenetic riskNoradrenergic functionLimbic regionsEffects of sexCognitive compositeFunctional connectivityAPOE-e4Higher Ab levelsControl networkFramewise displacementPredicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models
O’Neill A, Pax M, Parent J, Sepulcre J, Camprodon J, Noble S, Roffman J, Eryilmaz H. Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models. NPP—Digital Psychiatry And Neuroscience 2025, 3: 11. PMID: 40475845, PMCID: PMC12133584, DOI: 10.1038/s44277-025-00032-1.Peer-Reviewed Original ResearchConnectome-based predictive modelingEarly psychosisCognitive functionGoal of precision psychiatryPredictors of cognitive functionPrediction of cognitive functionPredicting cognitive performancePredicting cognitive functionModels of cognitionConnectome-based modelsPersonalized treatment developmentBrain connectivity patternsImpact functional outcomesHuman Connectome ProjectFluid cognitionPsychotic disordersSomatomotor networkCognitive abilitiesCognitive performancePrecision psychiatryVirtual lesion analysisTreatment developmentPsychosisCognitive outcomesCognitive impairmentSpatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging
Kim C, Diez I, Bueicheku E, Montal V, Sepulcre J. Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/3783.Peer-Reviewed Original ResearchTau accumulationCognitive changesPositron emission tomographyEarly cognitive changesLongitudinal positron emission tomographyAmyloid-betaCortical patternsAlzheimer's diseaseTauAging BrainCognitive scoresPreclinical ADOlder adultsSpatiotemporal levelsEmission tomographyBrainComplex roleAccumulationImaging markersAmyloidDifferential links in 16p11.2 deletion carriers reveal aberrant connections between large-scale networks
Qureshi A, Nielsen J, Sepulcre J. Differential links in 16p11.2 deletion carriers reveal aberrant connections between large-scale networks. Cerebral Cortex 2025, 35: bhae474. PMID: 40007052, PMCID: PMC11859958, DOI: 10.1093/cercor/bhae474.Peer-Reviewed Original ResearchConceptsInferior parietal lobuleSuperior temporal gyrusLarge-scale networksDeletion carriersHeteromodal association areasDifferential linksHypo-connectivitySocial impairmentTemporal gyrusParietal lobulePosterior insulaAssociated with greater communicationAberrant connectivityAssociation areasCingulate sulcusBehavioral changesGlobal coherenceEntangled connectionsSulcusGreater communicationInsulaCingulateGyrusCopy number variationsImpairmentMapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
Saiz-Masvidal C, De la Peña-Arteaga V, Bertolín S, Diez I, Juaneda-Seguí A, Martínez-Zalacaín I, Chavarría-Elizondo P, Subirà M, Menchón J, Sepulcre J, Fullana M, Soriano-Mas C. Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain. Brain Structure And Function 2025, 230: 137. PMID: 40828212, PMCID: PMC12364969, DOI: 10.1007/s00429-025-02996-4.Peer-Reviewed Original ResearchConceptsDorsal raphe nucleusVentral tegmental areaSubstantia nigra pars compactaFunctional connectivityMonoaminergic systemsRs-FCLocus coeruleusMedial frontal cortexResting-state functional MRIDorsal raphe nucleus projectsRs-fMRI analysisPrefrontal cortexTegmental areaFrontal cortexNeurotransmitter systemsRaphe nucleusDopaminergic pathwaysNeuropsychiatric conditionsInsular cortexNeurotransmitter networksBehavioral flexibilityMonoaminergic nucleiSubcortical regionsFunctional MRIBrain activity
2024
Stepwise pathways from the olfactory cortex to central hub regions in the human brain
Menelaou G, Diez I, Zelano C, Zhou G, Persson J, Sepulcre J, Olofsson J. Stepwise pathways from the olfactory cortex to central hub regions in the human brain. Human Brain Mapping 2024, 45: e26760. PMID: 39688149, PMCID: PMC11651219, DOI: 10.1002/hbm.26760.Peer-Reviewed Original ResearchConceptsDefault-mode networkCortical hubsHuman brainDefault-mode network regionsAnterior olfactory nucleusFunctional connectivity researchProcessing rewardOrbitofrontal cortexAnterior insulaOlfactory tubercleFrontal sulcusPiriform cortexOlfactory cortexCortical subregionsOlfactory nucleusAssociation cortexLanguage acquisitionParietal operculumNeural activityTemporal regionsCortical networksSynchronous neural activityOlfactory pathwaySensory cortexOlfactory systemAD Pathology Spreading Detection Using Directional Motifs in Brain Connectomes
Bueichekú E, Diez I, Úbeda A, Kim C, Jacobs H, Sepulcre J. AD Pathology Spreading Detection Using Directional Motifs in Brain Connectomes. Alzheimer's & Dementia 2024, 20: e088834. PMCID: PMC11710655, DOI: 10.1002/alz.088834.Peer-Reviewed Original ResearchTau progressionAlzheimer's diseaseNetwork motifsProgression of tau pathologyContext of ADFeed-forward loopToxic tauTau propagationTau proteinTau pathologyTau accumulationProtein spreadingMotifMotif networkEmergence of cognitive declineMedial prefrontal regionsAmyloid accumulationTauCharacteristics of pathologyMild cognitive impairmentAlzheimer's Disease Neuroimaging InitiativePrefrontal regionsTau PET dataBrain systemsClinical ADSubject‐level Detection of Focal Neurodegeneration Using Spatiotemporal Connectomics: Towards Atrophy Characterization in Preclinical Alzheimer's Disease
Sánchez C, Diez I, Bueichekú E, Kim C, Grothe M, Sanchez‐Juan P, Sepulcre J. Subject‐level Detection of Focal Neurodegeneration Using Spatiotemporal Connectomics: Towards Atrophy Characterization in Preclinical Alzheimer's Disease. Alzheimer's & Dementia 2024, 20: e093803. PMCID: PMC11713922, DOI: 10.1002/alz.093803.Peer-Reviewed Original ResearchAlzheimer's diseaseNeurodegenerative diseasesGraph-theory-based frameworkHealthy agingBrain atrophyVoxel-based morphometryGray matter measuresAtrophy phenotypeSingle-subject levelPreclinical Alzheimer's diseaseCognitively normal participantsT1 MRI scansDisease phenotypePhenotypic heterogeneityBrain mechanismsGraph theory approachLongitudinal MRI dataFocal neurodegenerationNormal participantsAtrophy patternsFollow-up timepointsGroups of subjectsPhenotypePreclinical ADStructural similaritySubject‐level Detection of Focal Neurodegeneration Using Spatiotemporal Connectomics: Towards Atrophy Characterization in Preclinical Alzheimer’s Disease
Sánchez C, Diez I, Bueichekú E, Kim C, Grothe M, Sanchez‐Juan P, Sepulcre J. Subject‐level Detection of Focal Neurodegeneration Using Spatiotemporal Connectomics: Towards Atrophy Characterization in Preclinical Alzheimer’s Disease. Alzheimer's & Dementia 2024, 20: e089064. PMCID: PMC11715297, DOI: 10.1002/alz.089064.Peer-Reviewed Original ResearchAlzheimer's diseaseNeurodegenerative diseasesGraph-theory-based frameworkHealthy agingBrain atrophyVoxel-based morphometryGray matter measuresAtrophy phenotypeSingle-subject levelPreclinical Alzheimer's diseaseCognitively normal participantsT1 MRI scansDisease phenotypePhenotypic heterogeneityBrain mechanismsGraph theory approachLongitudinal MRI dataFocal neurodegenerationNormal participantsAtrophy patternsFollow-up timepointsGroups of subjectsPhenotypePreclinical ADStructural similarityLongitudinal associations of microstructural changes, amyloid, and cognition in preclinical Alzheimer's disease
Vannini P, Bertazzoli G, Rodriguez‐Vieitez E, Ramseyer M, Diez I, Sepulcre J, Hanseeuw B, Lois C, Gagliardi G, Westin C, Johnson K, Sperling R, Marshall G. Longitudinal associations of microstructural changes, amyloid, and cognition in preclinical Alzheimer's disease. Alzheimer's & Dementia 2024, 20: e089927. PMCID: PMC11714664, DOI: 10.1002/alz.089927.Peer-Reviewed Original ResearchCortical mean diffusivityCognitive declineLongitudinal associationsCortical thicknessHarvard Aging Brain StudyBaseline cortical thicknessCN older adultsAging Brain StudyCompound B PETLongitudinal cognitive declinePreclinical Alzheimer's diseaseDrug-induced changesCognitive covariatesIsthmus cingulateStructural MRIPost-hoc stratifying analysisCognitive AssessmentAt-risk individualsCognitionGeneralized linear modelBrain studiesMean diffusivityOlder adultsGray matterDiffusion-weighted imaging