Skip to Main Content
Biological & Biomedical Sciences
Yale Home

INFORMATION FOR

    John MacMicking, PhD

    Professor of Microbial Pathogenesis and of Immunobiology
    DownloadHi-Res Photo

    Additional Titles

    Member, Yale Systems Biology Institute

    Investigator, Howard Hughes Medical Institute

    About

    Titles

    Professor of Microbial Pathogenesis and of Immunobiology

    Member, Yale Systems Biology Institute; Investigator, Howard Hughes Medical Institute

    Biography

    John MacMicking is a Howard Hughes Medical Institute (HHMI) Investigator, Professor of Microbial Pathogenesis and Professor of Immunobiology. He trained in synthetic organic chemistry at the Australian National University (B.Sc, 1st Class Honors) where he conducted thesis work in the Department of Immunology & Cell Biology formerly headed by 1996 Nobel Laureate, Peter Doherty, at the John Curtin School of Medical Research.

    He then came to the U.S. to pursue Ph.D studies with Carl Nathan in the Immunology program at Cornell University-Sloan-Kettering Institute in New York City before being selected as an HHMI Life Science Research Foundation Fellow at The Rockefeller University to conduct studies with John McKinney.

    His doctoral dissertation described the first knockout of an interferon (IFN)-induced defense protein in eukaryotes - inducible nitric oxide synthase (iNOS) - engineered between 1992-1995. It served as an early paradigm for cell-autonomous innate immunity to bacterial, viral and protozoan infections. At Rockefeller University he computationally identified, physically mapped and began functionally characterizing a complete IFN-inducible GTPase superfamily in humans and mice as a new defense network operating against all pathogen classes. For these discoveries he was named a Edward Mallinckrodt Jr Foundation Fellow (2004), Searle Scholar (2005), Cancer Research Institute Investigator (2006), Burroughs-Wellcome Fund Investigator (2008), CCFA Senior Research Awardee (2010), AAF Scholar (2014), and Kenneth Rainin Foundation Innovator (2014). In 2022, he received the Alumni Award of Distinction (Medical Sciences) from Cornell University.

    Dr. MacMicking was promoted to Associate Professor in 2010 and tenured in 2014. He was chosen as an HHMI Investigator in 2015 before moving to the Yale Systems Biology Institute in 2017.

    Appointments

    Other Departments & Organizations

    Education & Training

    Assistant Professor (Adjunct)
    The Rockefeller University (2007)
    Research Associate
    The Rockefeller University (2003)
    HHMI LSRF Fellow
    The Rockefeller University (2000)
    Revson Biomedical Fellow
    The Rockefeller University (1998)
    PhD
    Cornell University (1997)
    BSc (Hon)
    Australian National University (1990)

    Research

    Overview

    Medical Research Interests

    Cell Biology; Host-Pathogen Interactions; Immunity, Innate; Interferons

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of John MacMicking's published research.

    Publications

    Featured Publications

    See All Publications

    Academic Achievements & Community Involvement

    • activity

      Proceedings National Academy of Sciences USA

      Journal ServiceGuest Editor
    • activity

      Journal of Experimental Medicine

      Journal ServiceAssociate Editor
    • activity

      Scientific Advisory Board

      Advisory BoardsBoard Member
    • honor

      Alumni Award of Distinction

      National AwardCornell University
    • activity

      Cellular Microbiology

      Journal ServiceAssociate Editor
    See All Achievements

    Get In Touch

    Contacts

    Email
    Academic Office Number

    Administrative Support