Craig B. Wilen, MD, PhD
Cards
About
Titles
Associate Professor Term
Medical Director, Immune Monitoring Core FacilityBiography
Dr. Wilen is an Associate Professor in Laboratory Medicine and Immunobiology and is focused on the host-pathogen interactions of RNA viruses including coronavirus and norovirus. Dr. Wilen received his A.B in Biology and Economics at Washington University in St. Louis, his MD and PhD from the University of Pennsylvania. His residency training was in clinical pathology at Barnes-Jewish Hospital in St. Louis, MO. His postdoctoral studies were conducted in the laboratory of Herbert "Skip" Virgin at Washington University School of Medicine where he studied the pathogenesis of norovirus, the leading cause of acute gastroenteritis. Dr. Wilen discovered CD300lf as the first receptor for a norovirus and identified intestinal tuft cells as the physiologic target cell for mouse norovirus infection. Current work in the Wilen lab is focused on identifying novel therapeutic targets for SARS-CoV2 and elucidating mechanisms COVID-19 pathogenesis. The Wilen lab utilizes a diverse array of techniques to achieve these goals with SARS-CoV2 in the BSL3 including single-cell RNA sequencing, genome-wide CRISPR screening, organoid culture, and transgenic mouse models.
https://wilenlab.com
Appointments
Laboratory Medicine
Associate Professor on TermPrimaryImmunobiology
Associate Professor on TermSecondary
Other Departments & Organizations
- Center for Infection and Immunity
- Center for RNA Science and Medicine
- Clinical Chemistry Laboratory
- Genomics, Genetics, and Epigenetics
- Human and Translational Immunology Program
- Immune Monitoring Core Facility
- Immunobiology
- Immunology
- Laboratory Medicine
- Microbiology
- Virology Laboratories
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine
Education & Training
- Instructor
- Washington University School of Medicine (2018)
- Resident in Clinical Pathology
- Barnes-Jewish Hospital (2016)
- MD
- University of Pennsylvania, Perelman School of Medicine (2013)
- PhD
- University of Pennsylvania, Perelman School of Medicine (2011)
- AB
- Washington University in St. Louis, Biology and Economics (2006)
Research
Overview
Host-pathogen interaction, viral immunity
Medical Subject Headings (MeSH)
Academic Achievements and Community Involvement
Clinical Care
Overview
Clinical Specialties
Board Certifications
Clinical Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 2016
Links & Media
Media
Genome-wide CRISPR screen identifies genes critical for SARS-CoV-2-induced cell death.
Vero-E6 cells expressing Cas9 were transduced with a novel genome-wide C. sabaeus (vervet monkey) library via lentivirus. The transduced cell population then received either mock treatment or SARS-CoV-2 under various culture conditions and multiplicities of infection.Norovirus infection of tuft cells enables immune evasion
Mouse norovirus infection of tuft cells was observed in the small intestine of mice (Tuft cell marker DCLK1 in green; norovirus marker NS6/7 in red; nuclei in blue). The viral replication complex is located at the apical side of the tuft cell facing the gut lumen which may facilitate virus shedding and transmission.
News
- July 11, 2024Source: Yale Ventures
11 Yale Projects Receive Awards from the Colton Center for Autoimmunity
- April 19, 2024
Immunobiology Graduate Student Arya Ökten wins the 3-Minute Thesis Competition
- February 22, 2024
Yale School of Medicine Receives a $575,000 Grant From PolyBio Research Foundation to Fund Long COVID Research
- August 03, 2023
Lung Adenocarcinomas: New Findings About Resistance to Targeted Therapies