Hyojung Seo, PhD
Associate Professor of PsychiatryCards
About
Research
Overview
Medical Research Interests
Behavior, Animal; Learning; Memory; Neurophysiology; Prefrontal Cortex; Psychiatry; Schizophrenia
Publications
2024
Hierarchical gradients of multiple timescales in the mammalian forebrain
Song M, Shin E, Seo H, Soltani A, Steinmetz N, Lee D, Jung M, Paik S. Hierarchical gradients of multiple timescales in the mammalian forebrain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2415695121. PMID: 39671181, PMCID: PMC11665873, DOI: 10.1073/pnas.2415695121.Peer-Reviewed Original ResearchConceptsTask-related activityHierarchical gradientIntrinsic timescalesFeatures of cortical circuitsCorrelations of neural activityCortex of monkeysTemporal correlation of neural activityBrain regionsAssociation areasNeural activitySpatial receptive fieldsBasal gangliaThalamic activityConnectivity patternsCortical circuitsHierarchical axisCortical projectionsMammalian brainTimescalesMammalian forebrainCortexBrainHierarchical organizationProperties of synapsesMultiple timescalesTherapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making
Oemisch M, Seo H. Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making. ELife 2024, 12 DOI: 10.7554/elife.87529.3.Peer-Reviewed Original ResearchPotential antidepressant effectsDose of ketamineAntidepressant effectsKetamine's antidepressant actionRapid-acting antidepressantsPathophysiology of depressionImpact of negative eventsAntidepressant actionBehavioral perseverationAversive effectsNeuropsychological changesTreating depressionAffect memoryMood statesNegative eventsAdaptive behaviorSynaptic levelAffective eventsTemporal credit assignmentTherapeutic dosesDepressionCognitive aspectsInhibitory circuitryBehavioral changesAcute effectsTherapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making
Oemisch M, Seo H. Therapeutic doses of ketamine acutely attenuate the aversive effect of losses during decision-making. ELife 2024, 12: rp87529. PMID: 38700991, PMCID: PMC11068354, DOI: 10.7554/elife.87529.Peer-Reviewed Original ResearchConceptsDose of ketamineAntidepressant effectsKetamine's antidepressant actionPotential antidepressant effectsRapid-acting antidepressantsPathophysiology of depressionImpact of negative eventsAntidepressant actionBehavioral perseverationAversive effectsNeuropsychological changesTreating depressionAffect memoryMood statesNegative eventsAdaptive behaviorSynaptic levelAffective eventsTemporal credit assignmentTherapeutic dosesDepressionCognitive aspectsInhibitory circuitryBehavioral changesAcute effects
2017
Chapter 18 Reinforcement Learning and Strategic Reasoning During Social Decision-Making
Seo H, Lee D. Chapter 18 Reinforcement Learning and Strategic Reasoning During Social Decision-Making. 2017, 225-231. DOI: 10.1016/b978-0-12-805308-9.00018-x.Peer-Reviewed Original ResearchMultiple learning algorithmsLearning algorithmSocial decision-making taskDecision-making taskComplex social environmentComplex learning algorithmsEfficient learning algorithmHeuristic learning algorithmDifferent cortical areasPrefrontal cortexNeural activityReinforcement learningStrategic reasoningSocial environmentCortical areasAlgorithmBasal gangliaInformationTaskReasoningLearningSocialCortexIntentionPrevious studies
2014
Neural correlates of strategic reasoning during competitive games
Seo H, Cai X, Donahue CH, Lee D. Neural correlates of strategic reasoning during competitive games. Science 2014, 346: 340-343. PMID: 25236468, PMCID: PMC4201877, DOI: 10.1126/science.1256254.Peer-Reviewed Original Research
2013
Cortical Signals for Rewarded Actions and Strategic Exploration
Donahue CH, Seo H, Lee D. Cortical Signals for Rewarded Actions and Strategic Exploration. Neuron 2013, 80: 223-234. PMID: 24012280, PMCID: PMC3792491, DOI: 10.1016/j.neuron.2013.07.040.Peer-Reviewed Original Research
2009
Lateral Intraparietal Cortex and Reinforcement Learning during a Mixed-Strategy Game
Seo H, Barraclough DJ, Lee D. Lateral Intraparietal Cortex and Reinforcement Learning during a Mixed-Strategy Game. Journal Of Neuroscience 2009, 29: 7278-7289. PMID: 19494150, PMCID: PMC2743508, DOI: 10.1523/jneurosci.1479-09.2009.Peer-Reviewed Original ResearchBehavioral and Neural Changes after Gains and Losses of Conditioned Reinforcers
Seo H, Lee D. Behavioral and Neural Changes after Gains and Losses of Conditioned Reinforcers. Journal Of Neuroscience 2009, 29: 3627-3641. PMID: 19295166, PMCID: PMC2750005, DOI: 10.1523/jneurosci.4726-08.2009.Peer-Reviewed Original ResearchConceptsFrontal cortexDorsomedial frontal cortexBehavioral effectsConditioned reinforcersDorsal anterior cingulate cortexAnterior cingulate cortexMedial frontal cortexDorsolateral prefrontal cortexCingulate cortexNeural changesRhesus monkeysNeural effectsCortexPrefrontal cortexPrevious trialsSubsequent trialsNeural mechanisms
2007
Temporal Filtering of Reward Signals in the Dorsal Anterior Cingulate Cortex during a Mixed-Strategy Game
Seo H, Lee D. Temporal Filtering of Reward Signals in the Dorsal Anterior Cingulate Cortex during a Mixed-Strategy Game. Journal Of Neuroscience 2007, 27: 8366-8377. PMID: 17670983, PMCID: PMC2413179, DOI: 10.1523/jneurosci.2369-07.2007.Peer-Reviewed Original Research
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Congress Place, 301 Cedar St. Rm 319
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New Haven, CT 06519