Ken Huaijin Loh, PhD
Assistant Professor in Comparative MedicineDownloadHi-Res Photo
Cards
Appointments
Comparative Medicine
Primary
Contact Info
Yale University
PO Box 27391
West Haven, CT 06516-7392
United States
About
Titles
Assistant Professor in Comparative Medicine
Biography
Ken Loh is an Assistant Professor in the Department of Comparative Medicine in the Institute for Biomolecular Design and Discovery at Yale University’s West Campus. A native of Singapore, he received his B.S. in Chemistry from Harvey Mudd College in 2009 and earned his Ph.D in Chemistry with Alice Ting at MIT in 2016, developing chemical-enzymatic methodologies for tagging proteins in cells. Ken next received postdoctoral training with Jeffrey Friedman at Rockefeller University, studying the role of leptin in its regulation of sympathetic nerves in the fat organ, and joined the faculty at Yale in August of 2022. His lab is interested in studying brain-body interactions at a molecular length scale, using tools in chemical biology.
Appointments
Comparative Medicine
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- NIH Pathway to Independence K99 Fellow
- The Rockefeller University (2022)
- Helen Hay Whitney Postdoctoral Fellow
- The Rockefeller University (2021)
- PhD
- Massachusetts Institute of Technology, Chemistry (2016)
- BSc
- Harvey Mudd College, Chemistry (2009)
Research
Overview
Medical Research Interests
Autonomic Nervous System; Biochemistry; Diabetes Mellitus; Neurobiology; Obesity; Peripheral Nervous System; Proteomics; Synapses
Public Health Interests
Metabolism
- View Lab Website
Loh Laboratory
Research at a Glance
Yale Co-Authors
Frequent collaborators of Ken Huaijin Loh's published research.
Publications Timeline
A big-picture view of Ken Huaijin Loh's research output by year.
Sarah Slavoff
Haomiao Su
Marc Schneeberger Pane, PhD
Sidi Chen, PhD
8Publications
276Citations
Publications
2022
Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID
Na Z, Dai X, Zheng SJ, Bryant CJ, Loh KH, Su H, Luo Y, Buhagiar AF, Cao X, Baserga SJ, Chen S, Slavoff SA. Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID. Molecular Cell 2022, 82: 2900-2911.e7. PMID: 35905735, PMCID: PMC9662605, DOI: 10.1016/j.molcel.2022.06.035.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSubcellular localizationProximity biotinylationSmall open reading framesAlternative proteinsOpen reading frameHigh-throughput technologiesSubnuclear organellesCanonical proteinsRRNA transcriptionSubcellular compartmentsReading frameProteogenomic identificationProtein compositionAmino acidsMicroproteinsProteinBiotinylationLocalizationTurboIDTranscriptionOrganellesMouse modelPolypeptideNucleoliExpression
2020
A leptin-BDNF pathway regulating sympathetic innervation of adipose tissue.
Wang P, Loh KH, Wu M, Morgan DA, Schneeberger M, Yu X, Chi J, Kosse C, Kim D, Rahmouni K, Cohen P, Friedman J. A leptin-BDNF pathway regulating sympathetic innervation of adipose tissue. Nature 2020, 583: 839-844. PMID: 32699414, DOI: 10.1038/s41586-020-2527-y.Peer-Reviewed Original Research
2017
In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons
Chung CY, Khurana V, Yi S, Sahni N, Loh KH, Auluck PK, Baru V, Udeshi ND, Freyzon Y, Carr SA, Hill DE, Vidal M, Ting AY, Lindquist S. In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons. Cell Systems 2017, 4: 242-250.e4. PMID: 28131823, PMCID: PMC5578869, DOI: 10.1016/j.cels.2017.01.002.Peer-Reviewed Original Research
2016
A human microprotein that interacts with the mRNA decapping complex
D'Lima NG, Ma J, Winkler L, Chu Q, Loh KH, Corpuz EO, Budnik BA, Lykke-Andersen J, Saghatelian A, Slavoff SA. A human microprotein that interacts with the mRNA decapping complex. Nature Chemical Biology 2016, 13: 174-180. PMID: 27918561, PMCID: PMC5247292, DOI: 10.1038/nchembio.2249.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsProteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts.
Loh KH, Stawski PS, Draycott AS, Udeshi ND, Lehrman EK, Wilton DK, Svinkina T, Deerinck TJ, Ellisman MH, Stevens B, Carr SA, Ting AY. Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts. Cell 2016, 166: 1295-1307.e21. PMID: 27565350, PMCID: PMC5167540, DOI: 10.1016/j.cell.2016.07.041.Peer-Reviewed Original ResearchSpatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2.
Hung V, Udeshi ND, Lam SS, Loh KH, Cox KJ, Pedram K, Carr SA, Ting AY. Spatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2. Nature Protocols 2016, 11: 456-75. PMID: 26866790, PMCID: PMC4863649, DOI: 10.1038/nprot.2016.018.Peer-Reviewed Original Research
2013
Imaging trans-cellular neurexin-neuroligin interactions by enzymatic probe ligation.
Liu DS, Loh KH, Lam SS, White KA, Ting AY. Imaging trans-cellular neurexin-neuroligin interactions by enzymatic probe ligation. PloS One 2013, 8: e52823. PMID: 23457442, PMCID: PMC3573046, DOI: 10.1371/journal.pone.0052823.Peer-Reviewed Original Research
2012
Quantum dot targeting with lipoic acid ligase and HaloTag for single-molecule imaging on living cells.
Liu DS, Phipps WS, Loh KH, Howarth M, Ting AY. Quantum dot targeting with lipoic acid ligase and HaloTag for single-molecule imaging on living cells. ACS Nano 2012, 6: 11080-7. PMID: 23181687, PMCID: PMC3528850, DOI: 10.1021/nn304793z.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
honor 2025 ORAU Ralph E. Powe Junior Faculty Enhancement Award
National AwardORAUDetails05/29/2024United Stateshonor Klingenstein-Simons Fellowship Award in Neuroscience
National AwardEsther A. & Joseph Klingenstein FundDetails07/01/2023honor NIH Pathway to Independence Award K99/R00
National AwardNIH/NIDDKDetails08/11/2021honor Helen Hay Whitney Postdoctoral Fellowship
National AwardHelen Hay Whitney FoundationDetails04/01/2018
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Get In Touch
Contacts
Mailing Address
Yale University
PO Box 27391
West Haven, CT 06516-7392
United States
Administrative Support
Locations
Institute of Biomolecular Design and Discovery
Academic Office
West Campus Molecular Innovations Center
600 West Campus Drive, Rm 312D
West Haven, CT 06516
Business Office
203.737.3870
Events
Apr 202529Tuesday
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