Dylan Gee, PhD
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Featured Publications
Neural circuitry involved in conditioned inhibition via safety signal learning is sensitive to trauma exposure
Kribakaran S, Odriozola P, Cohodes E, McCauley S, Zacharek S, Hodges H, Haberman J, Pierre J, Gee D. Neural circuitry involved in conditioned inhibition via safety signal learning is sensitive to trauma exposure. Neurobiology Of Stress 2022, 21: 100497. PMID: 36532365, PMCID: PMC9755062, DOI: 10.1016/j.ynstr.2022.100497.Peer-Reviewed Original ResearchLeveraging the science of stress to promote resilience and optimize mental health interventions during adolescence
Gee DG, Sisk LM, Cohodes EM, Bryce NV. Leveraging the science of stress to promote resilience and optimize mental health interventions during adolescence. Nature Communications 2022, 13: 5693. PMID: 36171218, PMCID: PMC9519553, DOI: 10.1038/s41467-022-33416-4.Peer-Reviewed Original ResearchNeural effects of controllability as a key dimension of stress exposure
Cohodes EM, Odriozola P, Mandell JD, Caballero C, McCauley S, Zacharek SJ, Hodges HR, Haberman JT, Smith M, Thomas J, Meisner OC, Ellis CT, Hartley CA, Gee DG. Neural effects of controllability as a key dimension of stress exposure. Development And Psychopathology 2022, 35: 218-227. PMID: 35034670, DOI: 10.1017/s0954579421001498.Peer-Reviewed Original ResearchConceptsDorsal anterior insulaRight dorsal anterior insulaUncontrollable stress conditionUncontrollable stressStress exposureSex-matched participantsStressor controllabilityInitial exposureFunctional magnetic resonance imaging (fMRI) acquisitionSubsequent stress exposureNeural effectsAnterior insulaYoung adultsSubsequent stressorsPatterns of activityCross-species evidenceNeural correlatesSubsequent exposureExposureNeural underpinningsPresent studyParticipantsMagnetic resonance imaging (MRI) acquisitionAdaptive responseFMRI analysisEarly Adversity and Development: Parsing Heterogeneity and Identifying Pathways of Risk and Resilience
Gee DG. Early Adversity and Development: Parsing Heterogeneity and Identifying Pathways of Risk and Resilience. American Journal Of Psychiatry 2021, 178: 998-1013. PMID: 34734741, DOI: 10.1176/appi.ajp.2021.21090944.Peer-Reviewed Original ResearchConceptsEarly adversityProtective factorsEffects of adversityOnset of psychopathologyPathways of riskNeurodevelopmental trajectoriesMajor risk factorAdversityMental healthNeurodevelopmental pathwaysEarly environmentPsychopathologySpecific dimensionsIntervention strategiesFuture researchRisk factorsEarly risk identificationTreatment approachesImmense burdenConceptual modelDevelopmental timingResilienceOngoing refinementRiskFactorsAssociations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study
Brieant AE, Sisk LM, Gee DG. Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study. Developmental Cognitive Neuroscience 2021, 52: 101022. PMID: 34710799, PMCID: PMC8556598, DOI: 10.1016/j.dcn.2021.101022.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityNegative life eventsLife eventsInternalizing symptomsAdversity exposureCortico-limbic connectivityParental acceptanceAdolescent Brain Cognitive Development (ABCD) studyLongitudinal structural equation modelLower internalizing symptomsCognitive Development StudyContext of adversityIndirect effectsSample of youthStressful childhood experiencesCortico-limbic networkStructural equation modelLater psychopathologyNeurobiological maturationInternalizing problemsABCD studyFunctional connectivityChildhood experiencesPotential protective effectPsychopathology
2025
Preadolescent Family Conflict, Parental Depression, and Neural Circuitry Interact to Predict Adolescent Symptoms
Holt-Gosselin B, Basol E, Keding T, Rodrigues K, Joormann J, Gee D. Preadolescent Family Conflict, Parental Depression, and Neural Circuitry Interact to Predict Adolescent Symptoms. Journal Of The American Academy Of Child & Adolescent Psychiatry 2025 PMID: 40882867, DOI: 10.1016/j.jaac.2025.08.014.Peer-Reviewed Original ResearchAdolescent Brain Cognitive DevelopmentFunctional connectivityFamily conflictFamilial riskParental depressionPsychiatric symptomsNeural circuitryAged 9Patterns of neurodevelopmentResting-state networksAdolescent psychopathologyLR youthHR youthInternalizing symptomsAdolescent symptomsDepression historyRisk statusTotal problemsEnvironmental adversityPsychopathologyCognitive developmentCross-sectional designDepressionEffect sizePrognostic risk markersPsychological and Environmental Correlates of Locus of Control and Posttraumatic Stress Symptoms: A Latent Profile Analysis
Foster J, Cohodes E, Mandell J, McCauley S, Hodges H, Pierre J, Kribakaran S, Haberman J, Notti M, Schroeder M, Ababio R, Beloborodova A, Gee D. Psychological and Environmental Correlates of Locus of Control and Posttraumatic Stress Symptoms: A Latent Profile Analysis. Psychological Trauma Theory Research Practice And Policy 2025 PMID: 40811138, PMCID: PMC12422714, DOI: 10.1037/tra0002019.Peer-Reviewed Original ResearchPosttraumatic stress symptomsEarly-life stressLocus of controlLatent profile analysisStress symptomsPosttraumatic stress symptom severityDevelopment of posttraumatic stress symptomsLocus of control orientationPredictors of subgroup membershipMechanical Turk sampleProfile analysisStress-related symptomsFive-class solutionPerceptions of controlEnvironmental correlatesSubgroup membershipYoung adultsNonrepresentative samplesSymptomsUncontrollabilityIndividual membershipAdultsMembershipSubgroupsIndividualsTrauma-predictive brain network connectivity adaptively responds to mild acute stress
Hardi F, Ye J, Zhou I, Bai Z, Nguyen D, Loetscher K, Pratt J, Harris B, Gee D, Goldfarb E. Trauma-predictive brain network connectivity adaptively responds to mild acute stress. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2505965122. PMID: 40737323, PMCID: PMC12327799, DOI: 10.1073/pnas.2505965122.Peer-Reviewed Original ResearchConceptsBrain networksTrauma exposureAcute stressCommunity sampleConnectome-based predictive modelingCommunity sample of adultsAssociated with lower depressive symptomsMedial frontal cortexSalience network connectivityDefault mode networkMild acute stressLower depressive symptomsConnectivity of brain networksBrain network connectivityStress-exposed groupsSample of adultsSubsample of participantsFunctional connectivity networksRelative to controlsSalience networkFrontal cortexMode networkDepressive symptomsTraumatic experiencesMotor regionsThe Endocannabinoid System and Postnatal Neurodevelopment
Sisk L, Meyer H, Martinez-Garcia A, Gee D. The Endocannabinoid System and Postnatal Neurodevelopment. 2025, 83-112. DOI: 10.1007/978-3-031-87990-6_5.Peer-Reviewed Original ResearchStress-related disordersECB systemResilience to stress-related disordersMaturation of neuronal populationsResponse to stressECB signalingECB levelsFunctional connectivityHuman literaturePostnatal neurodevelopmentNeuronal populationsECBDisordersHuman studiesInfluence riskNeurodevelopmentEndocannabinoidAnxietyEndocrine systemRiskSignaling systemPotential riskYouthAdultsExposure to unpredictable childhood environments is associated with amygdala activation during early extinction in adulthood
Duda J, Keding T, Kribakaran S, Odriozola P, Kitt E, Cohodes E, Zacharek S, McCauley S, Haberman J, Joormann J, Gee D. Exposure to unpredictable childhood environments is associated with amygdala activation during early extinction in adulthood. Developmental Cognitive Neuroscience 2025, 74: 101578. PMID: 40493990, PMCID: PMC12179744, DOI: 10.1016/j.dcn.2025.101578.Peer-Reviewed Original ResearchUnpredictable childhood environmentsChildhood unpredictabilityExtinction learningAmygdala activationChildhood environmentAssociated with amygdala activationBasolateral amygdala activityChildhood trauma exposureSkin conductance responsesCross-species researchThreat cuesTrauma exposureNeural regionsSafety learningEarly adversityHealthy young adultsCurrent anxietyAssociated with activationConductance responsesCaregiving environmentAffective functioningHealthy neurodevelopmentNeural activityTargeted clinical interventionsIn adulthood
Academic Achievements & Community Involvement
News
News
- July 31, 2025Source: PNAS
Trauma-Predictive Brain Network Connectivity Adaptively Responds to Mild Acute Stress
- June 24, 2025
Announcing the Center for Brain & Mind Health 2025 Pilot Grant Program Awardees
- March 05, 2025Source: Yale News
For Some, Childhood Adversity Can Promote Resilience to Anxiety Disorders
- January 08, 2025
Study Led by Gee Named a 2024 Leading Research Achievement by BBRF
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