Carla Rothlin, PhD
Dorys McConnell Duberg Professor of Immunobiology and Professor of PharmacologyDownloadHi-Res Photo
Cards
Appointments
Immunobiology
Primary
Pharmacology
Secondary
Additional Titles
Co-Leader, Cancer Immunology, Yale Cancer Center
Contact Info
Appointments
Immunobiology
Primary
Pharmacology
Secondary
Additional Titles
Co-Leader, Cancer Immunology, Yale Cancer Center
Contact Info
Appointments
Immunobiology
Primary
Pharmacology
Secondary
Additional Titles
Co-Leader, Cancer Immunology, Yale Cancer Center
Contact Info
About
Titles
Dorys McConnell Duberg Professor of Immunobiology and Professor of Pharmacology
Co-Leader, Cancer Immunology, Yale Cancer Center
Appointments
Immunobiology
ProfessorPrimaryPharmacology
ProfessorSecondary
Other Departments & Organizations
- Cancer Immunology
- Immunobiology
- Immunology
- Interdepartmental Neuroscience Program
- K12 Calabresi Immuno-Oncology Training Program (IOTP)
- Liver Center
- Microbiology
- Neuroscience Track
- Pharmacology
- Program for Neuroinflammation
- Rheumatic Diseases Research Core
- Rothlin Ghosh Lab
- Status of Women in Medicine Committee (SWIM)
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Fibrosis Program
- Yale Stem Cell Center
- Yale Ventures
- YCC Diversity, Equity, and Inclusion
Education & Training
- PhD
- University of Buenos Aires (2002)
Research
Overview
Immunobiology; Immune Homeostasis; TAM Receptor Tyrosine Kinases
Medical Research Interests
Inflammation
ORCID
0000-0002-5693-5572
Research at a Glance
Yale Co-Authors
Frequent collaborators of Carla Rothlin's published research.
Publications Timeline
A big-picture view of Carla Rothlin's research output by year.
Research Interests
Research topics Carla Rothlin is interested in exploring.
Sourav Ghosh, PhD
Joseph Craft, MD
Aurobind Vidyarthi, PhD
Bony De Kumar, PhD
Eyiyemisi Damisah, MD
Jaime Grutzendler, MD
24Publications
2,200Citations
Inflammation
Publications
2024
868 AXL restricts cholesterol mobilization, modulating dendritic cell maturation and the immune response to cancer
Belabed M, Park M, Blouin C, Balan S, Moon C, Boumelha J, Peros A, Mattiuz R, Reid A, Azimi C, LaMarche N, Troncoso L, Berichel J, Wilk M, Brown B, Radford K, Ghosh S, Rothlin C, Yvan-Charvet L, Marron T, Puleston D, Bhardwaj N, Lamaze C, Merad M. 868 AXL restricts cholesterol mobilization, modulating dendritic cell maturation and the immune response to cancer. 2024, a982-a982. DOI: 10.1136/jitc-2024-sitc2024.0868.Peer-Reviewed Original ResearchNew potential ligand-receptor axis involved in tissue repair as therapeutic targets in progressive multiple sclerosis.
Carrera Silva E, Correale J, Rothlin C, Ortiz Wilczyñski J. New potential ligand-receptor axis involved in tissue repair as therapeutic targets in progressive multiple sclerosis. Journal Of Pharmacology And Experimental Therapeutics 2024, 100029. PMID: 39379148, DOI: 10.1124/jpet.124.002254.Peer-Reviewed Original ResearchAltmetricConceptsProgressive multiple sclerosisLigand-receptor axisNeuroprotective therapeutic strategiesMultiple sclerosisTissue repairTherapeutic strategiesRefractory to current treatmentsIncreasing preclinical evidenceStages of multiple sclerosisEarly stages of multiple sclerosisAnti-inflammatoryPromote tissue repairTissue repair processPreclinical evidenceTherapeutic optionsReceptor axisReceptor/ligand pairsCurrent treatmentPathogenic mechanismsMS diseaseBenefit patientsTherapeutic interventionsTherapeutic targetSignaling axisEra of omicsFeeding the wrath with myelin
Ghosh S, Rothlin C. Feeding the wrath with myelin. Trends In Immunology 2024, 45: 729-731. PMID: 39341708, PMCID: PMC11471388, DOI: 10.1016/j.it.2024.09.004.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsStem cells tightly regulate dead cell clearance to maintain tissue fitness
Stewart K, Abdusselamoglu M, Tierney M, Gola A, Hur Y, Gonzales K, Yuan S, Bonny A, Yang Y, Infarinato N, Cowley C, Levorse J, Pasolli H, Ghosh S, Rothlin C, Fuchs E. Stem cells tightly regulate dead cell clearance to maintain tissue fitness. Nature 2024, 633: 407-416. PMID: 39169186, PMCID: PMC11390485, DOI: 10.1038/s41586-024-07855-6.Peer-Reviewed Original ResearchCitationsAltmetricConceptsStem cellsImmune-privileged nicheHair follicle stem cellsStem cell functionFollicle stem cellsTissue fitnessMesenchymal tissue cellsBillions of cellsDendritic cellsTissue stemProgenitor cellsPreserving tissue integrityDead cell clearanceClearance genesCell clearanceCell functionFunctional evidenceDying cellsHealthy counterpartsCell deathNon-motileTissue cellsHair cycleProfessional phagocytesApoptotic corpsesThe amalgam of naive CD4+ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response
Even Z, Meli A, Tyagi A, Vidyarthi A, Briggs N, de Kouchkovsky D, Kong Y, Wang Y, Waizman D, Rice T, De Kumar B, Wang X, Palm N, Craft J, Basu M, Ghosh S, Rothlin C. The amalgam of naive CD4+ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response. Immunity 2024, 57: 1893-1907.e6. PMID: 39096910, PMCID: PMC11421571, DOI: 10.1016/j.immuni.2024.07.006.Peer-Reviewed Original ResearchCitationsAltmetricConceptsT cell receptorImmune responseNaive CD4<sup>+</sup> T cellsCD4<sup>+</sup> T cellsIFN-IHelminth infectionsNippostrongylus brasiliensis infectionDecreased immune responseType I interferonNaive TT cellsMemory-likeUnrelated antigensTranscriptional changesExtracellular matrixSPF miceCell receptorsI interferonGerm-freeResponse to certain environmental cuesInfectionMiceFunctional changesCell transcriptional statesTranscriptional heterogeneityHow and why eLife selects papers for peer review
Behrens T, Dalal Y, Harper D, Weigel D, Ajijola O, Andreotti A, Araújo S, Banerjee U, Bhargava B, Bi Y, Büchel C, Campelo F, Cardona A, Cheah K, Chen L, Choi M, Colgin L, Cooper J, Cui Q, de Lange F, Desplan C, Dötsch V, El-Deiry W, Franco E, Frank M, Garrett W, Gold J, Hauf S, Huang C, Huguenard J, James D, Kana B, Kapahi P, King A, Kleine-Vehn J, Kornmann B, Liu C, Luo H, Maduke M, Makin T, Marquand A, Marston A, Mistry P, Moses A, Nelson S, Ng T, Ojala P, Perry G, Poirazi P, Postovit L, Ramachandran S, Rasmann S, Rath S, Roiser J, Ron D, Rothlin C, Schoggins J, Schuman M, Shinn-Cunningham B, Shoback D, Smith L, Soldati-Favre D, Stainier D, Sussel L, Swartz K, Taffe M, Taniguchi T, VijayRaghavan K, Walczak A, Wassum K, White R, Wong M, Yan W, Yuen T, Chugh M, Han L, Marei S, Mencia R, Mittal D, Ochola E, Romani F, Yap L. How and why eLife selects papers for peer review. ELife 2024, 13: e100571. PMID: 39041434, PMCID: PMC11265793, DOI: 10.7554/elife.100571.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsIn the Eyes of the Beholder—New Mertk Knockout Mouse and Re-Evaluation of Phagocytosis versus Anti-Inflammatory Functions of MERTK
Ghosh S, Finnemann S, Vollrath D, Rothlin C. In the Eyes of the Beholder—New Mertk Knockout Mouse and Re-Evaluation of Phagocytosis versus Anti-Inflammatory Functions of MERTK. International Journal Of Molecular Sciences 2024, 25: 5299. PMID: 38791338, PMCID: PMC11121519, DOI: 10.3390/ijms25105299.Peer-Reviewed Original ResearchCitationsConceptsReceptor tyrosine kinasesFamily of receptor tyrosine kinasesTAM family of receptor tyrosine kinasesEarly-onset photoreceptor degenerationKnockout mouse modelMolecular functionsNegative regulator of inflammationKnockout phenotypesNegative regulatorMouse geneticsRegulation of inflammationMolecular approachesEmbryonic stem cellsAnti-inflammatory functionsRetinal degenerationTyrosine kinasePhotoreceptor degenerationKnockout miceKnockout modelsMouse modelRodent modelsTAM familyMerTK functionStem cellsAllelesApoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages
Liebold I, Al Jawazneh A, Casar C, Lanzloth C, Leyk S, Hamley M, Wong M, Kylies D, Gräfe S, Edenhofer I, Aranda-Pardos I, Kriwet M, Haas H, Krause J, Hadjilaou A, Schromm A, Richardt U, Eggert P, Tappe D, Weidemann S, Ghosh S, Krebs C, A-Gonzalez N, Worthmann A, Lohse A, Huber S, Rothlin C, Puelles V, Jacobs T, Gagliani N, Bosurgi L. Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages. Science 2024, 384: eabo7027. PMID: 38574142, DOI: 10.1126/science.abo7027.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsApoptotic neutrophilsApoptotic cellsIL-4-induced gene expressionUptake of apoptotic neutrophilsApoptotic cell clearanceCell lineage identityResponse to IL-4Cell identityEfferocytic macrophagesPhagocytic receptorsGene expressionLineage identityCell clearanceApoptotic hepatocytesHeterogeneous cellsCellsMouse modelT cellsParasite-induced pathologyIL-4HepatocytesMacrophagesInterleukin-4EngulfmentPhenotypeTREM2 function in glioblastoma immune microenvironment: Can we distinguish reality from illusion?
Ghosh S, Rothlin C. TREM2 function in glioblastoma immune microenvironment: Can we distinguish reality from illusion? Neuro-Oncology 2024, 26: 840-842. PMID: 38290471, PMCID: PMC11066908, DOI: 10.1093/neuonc/noae019.Peer-Reviewed Original Research
2023
Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential
Hamley M, Leyk S, Casar C, Liebold I, Al Jawazneh A, Lanzloth C, Böttcher M, Haas H, Richardt U, Rothlin C, Jacobs T, Huber S, Adlung L, Pelczar P, Henao‐Mejia J, Bosurgi L. Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential. European Journal Of Immunology 2023, 54: e2350434. PMID: 37971166, DOI: 10.1002/eji.202350434.Peer-Reviewed Original ResearchAltmetricConceptsMucosal healingSchistosoma mansoni infectionCytokines IL-4Innovative therapeutic approachesDifferent intestinal diseasesWound-healing potentialIntestinal damageMucosal responsesMansoni infectionInflamed colonIL-4Intestinal disordersIntestinal diseaseNormal mucosaMurine modelTherapeutic approachesNovel regulatorType 2Advanced stageTherapy efficacyMacrophage responseCell therapyHealing potentialNew targetsIntestinal regeneration
Academic Achievements & Community Involvement
honor HHMI Faculty Scholar
National AwardHoward Hughes Medical InstituteDetails10/01/2016United Stateshonor Early Excellence Award
UnknownAmerican Asthma FoundationDetails07/01/2011United Stateshonor Novel Research Grant
UnknownLupus Research InstituteDetails02/01/2011United Stateshonor Senior Research Award
UnknownCrohn's and Colitis Foundation of AmericaDetails01/01/2010United Stateshonor Special Fellow (declined in favor of AHA award)
UnknownLeukemia and Lymphoma SocietyDetails05/02/2008United States
News
News
- January 01, 2024Source: Cytokine Society
ICIS Council Member Carla Rothlin Takes the Global ImmunoCourse to India
- February 28, 2021
MD-PhD Student Eric Song Receives Prestigious Harold M. Weintraub Graduate Student Award
- February 24, 2021
Releasing the Brakes on an Innate Immune System Response
- June 11, 2020
Global Immunospeaker Virtual Seminar Series Is Available Weekly
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Academic Office
300 Cedar Street, Ste S625A
New Haven, CT 06519