2024
Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation.
Que Z, Olivero-Acosta M, Robinson M, Chen I, Zhang J, Wettschurack K, Wu J, Xiao T, Otterbacher C, Shankar V, Harlow H, Hong S, Zirkle B, Wang M, Cui N, Mandal P, Chen X, Deming B, Halurkar M, Zhao Y, Rochet J, Xu R, Brewster A, Wu L, Yuan C, Skarnes W, Yang Y. Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation. Journal Of Neuroscience 2024, e2027232024. PMID: 39557580, DOI: 10.1523/jneurosci.2027-23.2024.Peer-Reviewed Original ResearchNeuronal excitabilityHyperexcitable neuronsHuman microgliaCo-cultureVoltage-gated sodium channel Nav1.2Neuronal activityRepetitive action potential firingRodent models of seizuresBrain-resident immune cellsSodium channel expressionInfluence neuronal excitabilityAction potential firingHyperexcitability of cortical neuronsModulates neuronal excitabilityEpilepsy-causing mutationsSodium channel Nav1.2Resident immune cellsAbnormal neuronal activityPresence of microgliaSuppression of seizuresModulate neuronal activityDensity of sodium channelsModels of seizuresPresence of neuronsAxon initial segmentConstrained nuclear-electronic orbital QM/MM approach for simulating complex systems with quantum nuclear delocalization effects incorporated
Zhao X, Chen Z, Yang Y. Constrained nuclear-electronic orbital QM/MM approach for simulating complex systems with quantum nuclear delocalization effects incorporated. Chemical Physics Reviews 2024, 5: 041401. DOI: 10.1063/5.0226271.Peer-Reviewed Original ResearchNuclear quantum effectsDelocalization effectQM/MM approachLow barrier hydrogen bondHybrid quantum mechanics/molecular mechanicsHydrogen-bonded complexesHydrogen-bonded structureQuantum mechanics/molecular mechanicsElectrostatic embedding schemeProton sharingSolvation effectsQM/MM implementationQM methodsHydrogen bondsQM/MMQuantum effectsBonding structureNuclear-electronicBiological systemsMM methodComplex chemicalSimulating complex chemicalSolvationAccurate descriptionChemicalSpatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARS‐CoV‐2 Variants
Zhang J, Xu Y, Chen M, Wang S, Lin G, Huang Y, Yang C, Yang Y, Song Y. Spatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARS‐CoV‐2 Variants. Angewandte Chemie International Edition 2024, 63: e202412294. PMID: 39030890, DOI: 10.1002/anie.202412294.Peer-Reviewed Original ResearchNanoparticle vaccineReceptor-binding domainHeterotypic antigensBroad-spectrum neutralizing antibodiesSARS-CoV-2 spike trimerVaccine-induced immunityNanotechnology-based strategiesEnhanced immune activationOmicron receptor-binding domainMosaic vaccinesImmune activationSystematic in vitroNeutralizing antibodiesSARS-CoV-2 variantsMosaic nanoparticlesImmunological investigationsExcessive inflammationAntigen distributionAntigenSpike trimerRBD antigenSARS-CoV-2DNAVaccineAntiviral capabilitiesSpatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARS‐CoV‐2 Variants
Zhang J, Xu Y, Chen M, Wang S, Lin G, Huang Y, Yang C, Yang Y, Song Y. Spatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARS‐CoV‐2 Variants. Angewandte Chemie 2024, 136 DOI: 10.1002/ange.202412294.Peer-Reviewed Original ResearchNanoparticle vaccineReceptor-binding domainHeterotypic antigensBroad-spectrum neutralizing antibodiesSARS-CoV-2 spike trimerVaccine-induced immunityNanotechnology-based strategiesEnhanced immune activationOmicron receptor-binding domainMosaic vaccinesImmune activationSystematic in vitroNeutralizing antibodiesSARS-CoV-2 variantsMosaic nanoparticlesImmunological investigationsExcessive inflammationAntigen distributionAntigenSpike trimerRBD antigenSARS-CoV-2DNAVaccineAntiviral capabilitiesCarrier-free multifunctional nanomedicine for enhanced hyperthermic intraperitoneal chemotherapy against abdominal pelvic tumors
Fang H, Zhang L, Wu Y, Chen L, Deng Z, Zheng Z, Wang Y, Yang Y, Chen Q. Carrier-free multifunctional nanomedicine for enhanced hyperthermic intraperitoneal chemotherapy against abdominal pelvic tumors. Chemical Engineering Journal 2024, 498: 155781. DOI: 10.1016/j.cej.2024.155781.Peer-Reviewed Original ResearchHyperthermic intraperitoneal chemotherapyImmunogenic cell deathDamage-associated molecular patternsPelvic tumorsIntraperitoneal chemotherapyGambogic acidAnti-tumor immune response in vivoInfiltration of cytotoxic T lymphocytesTriggering immunogenic cell deathRelease of damage-associated molecular patternsCancer cellsImmune responses in vivoCytotoxic T lymphocytesInduce apoptosis of cancer cellsApoptosis of cancer cellsResponses in vivoInhibitor of heat shock proteinCell deathHyperthermia-induced cell deathPenetration of nanoparticlesTumor extracellular matrixHeat shock proteinsOvarian cancerTumor microenvironmentT lymphocytesWhere is the hidden intramolecular H-bonding vibrational signal in the proline matrix IR spectrum?
Langford J, Zhang Y, Chen Z, Yang Y. Where is the hidden intramolecular H-bonding vibrational signal in the proline matrix IR spectrum? The Journal Of Chemical Physics 2024, 161: 134302. PMID: 39351935, DOI: 10.1063/5.0226184.Peer-Reviewed Original ResearchQuantifying network behavior in the rat prefrontal cortex
Sha C, Wang J, Mailman R, Yang Y, Dokholyan N. Quantifying network behavior in the rat prefrontal cortex. Frontiers In Computational Neuroscience 2024, 18: 1293279. PMID: 39268151, PMCID: PMC11390430, DOI: 10.3389/fncom.2024.1293279.Peer-Reviewed Original ResearchPrefrontal cortexT-maze alternation taskMedial prefrontal cortexWorking memory processesRat prefrontal cortexLocal field potential recordingsDynamic time warpingField potential recordingsAlternation taskT-mazeMemory processesPsychiatric disordersRat behaviorLocal field potentialsPrimate literatureNeural activitySpike trainsInsufficient statistical powerTime warpingNeural network synchronizationCortexElectrophysiological activityPotential recordingsNeuronal spike trainsField potentialsA Minimalist Pathogen‐Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy
Miao Y, Niu L, Lv X, Zhang Q, Xiao Z, Ji Z, Chen L, Liu Y, Liu N, Zhu J, Yang Y, Chen Q. A Minimalist Pathogen‐Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy. Advanced Materials 2024, 36: e2410715. PMID: 39210649, DOI: 10.1002/adma.202410715.Peer-Reviewed Original ResearchCancer immunotherapyMaturation of antigen-presenting cellsVaccine carriersImmune checkpoint blockade therapyAntigen-specific immune responsesInhibition of tumor growthCheckpoint blockade therapyEnhanced cancer immunotherapyAntigen-presenting cellsVaccine delivery technologiesB16-OVABlockade therapyImmune activationTumor modelTumor growthAntigen loadNanovaccineImmune responseMeticulous screeningAntigenic peptidesImmunostimulatory characteristicsChain ratioDelivery technologiesImmunotherapyIn vivoExpression and prognostic value of cell‐cycle‐associated genes in lung squamous cell carcinoma
Xu X, Jin K, Xu X, Yang Y, Zhou B. Expression and prognostic value of cell‐cycle‐associated genes in lung squamous cell carcinoma. The Journal Of Gene Medicine 2024, 26: e3735. PMID: 39171952, DOI: 10.1002/jgm.3735.Peer-Reviewed Original ResearchConceptsCell cycle-associated genesLung squamous carcinomaCell cycleMRNA expression dataGene expression profilesAssociated with positive prognosisCause of cancer-related deathExpression dataCancer Genome AtlasExpressed genesSquamous cell carcinomaLung squamous cell carcinomaTargeted therapy trialsGroup of patientsCancer-related deathsExpression of CDK4GenesExpression trendsExpression profilesMolecular studiesGenome AtlasSquamous carcinomaCell carcinomaPathological stagePrognostic valueAn Efficient Prototype-Based Clustering Approach for Edge Pruning in Graph Neural Networks to Battle Over-Smoothing
Huang Y, Lu W, Yang Y. An Efficient Prototype-Based Clustering Approach for Edge Pruning in Graph Neural Networks to Battle Over-Smoothing. 2024, 4201-4209. DOI: 10.24963/ijcai.2024/464.Peer-Reviewed Original ResearchGraph neural networksOver-smoothingNeural networkIssue of over-smoothingIntra-class edgesEmbeddings of nodesGroup of nodesGNNs’ performanceNode representationsSupervision signalsClass labelsPreserving smoothingInter-classEfficient clusteringEdge pruningGraph structureDiverse graphsClustering approachTopology augmentationGraphNodesEnhanced accuracyNetworkAccuracyScalabilityModulated Cell Internalization Behavior of Icosahedral DNA Framework with Programmable Surface Modification
Huang K, Yang Q, Bao M, Wang S, Zhao L, Shi Q, Yang Y. Modulated Cell Internalization Behavior of Icosahedral DNA Framework with Programmable Surface Modification. Journal Of The American Chemical Society 2024, 146: 21442-21452. PMID: 39038211, DOI: 10.1021/jacs.4c04106.Peer-Reviewed Original ResearchCGMega: explainable graph neural network framework with attention mechanisms for cancer gene module dissection
Li H, Han Z, Sun Y, Wang F, Hu P, Gao Y, Bai X, Peng S, Ren C, Xu X, Liu Z, Chen H, Yang Y, Bo X. CGMega: explainable graph neural network framework with attention mechanisms for cancer gene module dissection. Nature Communications 2024, 15: 5997. PMID: 39013885, PMCID: PMC11252405, DOI: 10.1038/s41467-024-50426-6.Peer-Reviewed Original ResearchAn emerging antibacterial nanovaccine for enhanced chemotherapy by selectively eliminating tumor-colonizing bacteria
Chen L, Kang Z, Shen J, Zhao R, Miao Y, Zhang L, Zheng Z, Zhang Z, Liu N, Wang C, Fang H, Zhou J, Wang Y, Liu Z, Yang Y, Chen Q. An emerging antibacterial nanovaccine for enhanced chemotherapy by selectively eliminating tumor-colonizing bacteria. Science Bulletin 2024, 69: 2565-2579. PMID: 38918142, DOI: 10.1016/j.scib.2024.06.016.Peer-Reviewed Original ResearchConceptsF. nucleatumColorectal cancerEffective antigen presentationEnhance chemotherapy efficacyT cell activationReduce cancer metastasisPoor treatment outcomesIncreased cancer cell growthCancer cell growthOral anaerobesDendritic cellsFusobacterium nucleatumChemotherapy efficacyAntitumor effectAntigen presentationBiomimetic nanovaccinesEnhanced chemotherapyNanovaccineAlum adjuvantCpG oligonucleotidesTreatment outcomesImmune responseImmune progressionTherapeutic effectVaccine effectivenessPassing Behavior of Oligonucleotides through a Stacked DNA Nanochannel with Featured Path Design
Zhang R, Xiang Y, Yang Y. Passing Behavior of Oligonucleotides through a Stacked DNA Nanochannel with Featured Path Design. Journal Of The American Chemical Society 2024, 146: 17122-17130. PMID: 38861703, DOI: 10.1021/jacs.4c02734.Peer-Reviewed Original ResearchFusobacterium nucleatum-mimicking nanovehicles to overcome chemoresistance for breast cancer treatment by eliminating tumor-colonizing bacteria
Chen L, Shen J, Kang Z, Zhang Z, Zheng Z, Zhang L, Xiao Z, Zhang Q, Fang H, Zhou J, Wang Y, Yang Y, Liu Z, Chen Q. Fusobacterium nucleatum-mimicking nanovehicles to overcome chemoresistance for breast cancer treatment by eliminating tumor-colonizing bacteria. Chem 2024, 10: 1783-1803. DOI: 10.1016/j.chempr.2024.01.030.Peer-Reviewed Original ResearchBreast cancerRegression of established tumorsLung metastasis of breast cancerMetastasis of breast cancerBroad-spectrum antibioticsBreast cancer treatmentBreast cancer chemotherapyEstablished tumorsIntratumoral microbiomeF. nucleatumLung metastasesChemotherapy efficacyOvercome chemoresistanceCancer therapyPromote chemoresistanceCancer chemotherapyCancer treatmentBreastCancerDrug delivery carriersTumorChemoresistanceDelivery carriersNanovehiclesEfficacyDopamine D1 Receptor Agonists Rescue Age-related Decline in Temporal Order Memory
Bransom L, Bassett A, Zhou M, Cimino J, Mailman R, Yang Y. Dopamine D1 Receptor Agonists Rescue Age-related Decline in Temporal Order Memory. Neuroscience 2024, 551: 177-184. PMID: 38823551, PMCID: PMC11246218, DOI: 10.1016/j.neuroscience.2024.05.033.Peer-Reviewed Original ResearchTemporal order memoryOrder memoryAge-related declineDopamine D1 receptor agonistTreating age-related cognitive declineAge-related cognitive declineReceptor agonistsSpatial working memoryD1 receptor agonistPoorer memory performanceWorking memoryMemory performanceCognitive declineEffects of ageRecognition taskEffect sizeIndividual ratsMemoryOld ratsOptimal effective doseDopamineImproved therapeutic indexAgonistsTherapeutic indexFunctional selectivityTherapeutic nanobodies against SARS-CoV-2 and other pathogenic human coronaviruses
Yang Y, Li F, Du L. Therapeutic nanobodies against SARS-CoV-2 and other pathogenic human coronaviruses. Journal Of Nanobiotechnology 2024, 22: 304. PMID: 38822339, PMCID: PMC11140877, DOI: 10.1186/s12951-024-02573-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, NeutralizingAntibodies, ViralBetacoronavirusCoronavirus InfectionsCOVID-19HumansMiddle East Respiratory Syndrome CoronavirusPandemicsPneumonia, ViralSARS-CoV-2Severe acute respiratory syndrome-related coronavirusSingle-Domain AntibodiesSpike Glycoprotein, CoronavirusVirus InternalizationConceptsReceptor-binding domainPathogenic human CoVsHeavy-chain antibodiesSARS-CoV-2Development of nanobiotechnologiesPathogenic human coronavirusesSingle-domain antibodiesSARS-CoV-2 variantsS proteinViral entry processHuman CoVsViral spikeReemerging pathogensEvaluation of therapeutic agentsSARS-CoVVirus pathogenesisVariable domainsNanobodiesViral structuresPandemic potentialMERS-CoVPathogenic coronavirusesViral entryBinding affinityHuman coronavirusesSpectroscopic Quantification of the Inverted Singlet–Triplet Gap in Pentaazaphenalene
Wilson K, Styers W, Wood S, Woods R, McMahon R, Liu Z, Yang Y, Garand E. Spectroscopic Quantification of the Inverted Singlet–Triplet Gap in Pentaazaphenalene. Journal Of The American Chemical Society 2024, 146: 15688-15692. PMID: 38815061, DOI: 10.1021/jacs.4c05043.Peer-Reviewed Original ResearchSinglet-triplet gapComputational electronic structure methodsInverted singlet-triplet gapAnion photoelectron spectroscopyExcited singlet stateDouble excitation characterElectronic structure methodsHund's multiplicity ruleVisible absorption spectroscopySpectroscopic quantificationArgon matrixLowest singletTriplet stateOrganic chromophoresSinglet stateExcitation characterAbsorption spectroscopyElectronic statesPhotoelectron spectroscopyStructure methodsSpectroscopyAccurate quantificationChromophoreSingletQuantificationStrategically Staged Tumor Ablation and Inflammation Suppression Using Shell‐Core Nanoparticles to Eradicate Bladder Tumors and Prevent Recurrence
Xu Y, Zhang R, Zhu J, Guo Z, Jin D, Qian L, Yang Y, Chen H. Strategically Staged Tumor Ablation and Inflammation Suppression Using Shell‐Core Nanoparticles to Eradicate Bladder Tumors and Prevent Recurrence. Advanced Functional Materials 2024, 34 DOI: 10.1002/adfm.202402078.Peer-Reviewed Original ResearchPrevent tumor recurrenceBladder tumorsTumor recurrenceTumor ablationPreventing bladder tumor recurrenceRat bladder tumor modelBladder tumor modelBladder tumor recurrenceInflammation suppressionCancer-related inflammationRelease of nitric oxideAnti-inflammatory effectsAcidic tumor environmentTumor environmentTumor modelPrevent recurrenceReduce inflammationTumorRecurrenceInflammationReactive oxygen speciesNitric oxideIn vitroAbstract NanomedicineAnti-tumorActively contractible and antibacterial hydrogel for accelerated wound healing
Ji Z, Wei T, Zhu J, Hu J, Xiao Z, Bai B, Lv X, Miao Y, Chen M, Wang C, Pan F, Yang Y, Li M, Chen Q. Actively contractible and antibacterial hydrogel for accelerated wound healing. Nano Research 2024, 17: 7394-7403. DOI: 10.1007/s12274-024-6674-6.Peer-Reviewed Original ResearchAdhesive hydrogelsPoly(N-isopropyl acrylamideAntibacterial hydrogelsFull-thickness skin defect modelMouse full-thickness skin defect modelSkin defect modelPNIPAAm networkEfficient antibacterial abilityMechanical propertiesThermoresponsive polymersHydrogelsDefect modelShrinkage abilityAntibacterial abilityImproved wound healing processTissue regenerationCatechol groupsAccelerated wound healingAntibacterial propertiesWound moistTissue adhesivesAntibacterial functionReactive oxygen speciesAdhesion abilityAdhesion