Kofi Mensah, MD, PhD
About
Biography
Dr Mensah is a graduate of the NIH medical-scientist training program (MSTP) at the University of Rochester where he received his PhD in immunology under the direction of Edward Schwarz, PhD and Christopher Ritchlin, MD. His dissertation looked at immune system regulation of osteoclastogenesis in the context of inflammatory arthritis. His dissertation received the Melville A. Hare Award for Distinction in Research (2009). His other research mentors included John Mudgett, PhD at Merck Research Laboratories, Steven Teitelbaum, MD and F. Patrick Ross, PhD at Washington University in St Louis, as well as Steven Goldring, MD, Edward Purdue, PhD, Lionel Ivashkiv, MD, and Joseph Lane, MD at Hospital for Special Surgery, Joseph Craft, MD and Eric Meffre, PhD at Yale. He has presented at many international congresses including, American College of Rheumatology annual meeting and the American Society for Clinical Investigation annual meeting. He received the Robert Leet Patterson and Clara Guthrie Patterson Trust Mentored Research Award during his post-doc at Yale. He is a co-inventor on several patents. Dr Mensah is a member of the Alpha Omega Alpha and Phi Beta Kappa honor societies. He served on the Executive Council for the Yale Internal Medicine Residency Program and the Board of Directors of the American Physician Scientists Association. He has mentored high school, undergraduate, graduate and medical students. As part of his mentorship role, he has worked with the New York City Science and Engineering Fair and the New England Science Symposium.
Appointments
Rheumatology
Assistant Clinical ProfessorPrimary
Other Departments & Organizations
Education & Training
- Residency
- Yale University (2015)
- Residency
- Hospital for Special Surgery/Weill Cornell (2013)
- MD
- University of Rochester School of Medicine and Dentistry (2011)
- PhD
- University of Rochester School of Medicine and Dentistry (2009)
Board Certifications
Rheumatology
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2018
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2016
Research
Overview
Medical Research Interests
Publications
2014
Chapter 2. Diagnosis and Imaging of Insufficiency Fractures
Mensah KA and Schneider R. Insufficiency Fractures. Eds. Lane JM and Saleh A. Rosemont, IL: American Academy of Orthopaedic Surgeons, 2014.Peer-Reviewed Original Research
2013
Chapter 6. Basic Science of Immunology in Orthopaedics
Mensah KA and O’Keefe RJ. Orthopaedic Basic Science: Foundations of Clinical Practice, Fourth Edition. Eds. O'Keefe RJ, Jacobs JJ, Chu CR, and Einhorn TA. Rosemont, IL: American Academy of Orthopaedic Surgeons, 2013.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
activity American Physician Scientists Association
Professional OrganizationsBoard MemberDetailsBoard of Directors04/30/2014 - Presentactivity Yale Internal Medicine Residency Program
CommitteesMemberDetailsExecutive Council Member09/01/2013 - 06/29/2015honor Alpha Omega Alpha Honor Medical Society
International AwardAlpha Omega AlphaDetails02/28/2011United Statesactivity REF Marshall J. Schiff Memorial Lectureship in Inflammation and Joint Replacement: The Surface Expression Level of DC-STAMP Defines the Fusogenic Potential of Osteoclast Precursors (OCP): RANKL-Induced DC-STAMPlo OCP Are the Master-Fusogens
LectureAmerican College of Rheumatology Scientific MeetingDetails10/18/2009 - 10/18/2009Philadelphia, PA, United StatesAbstract/SynopsisOsteoclasts (OC) form by fusion of heterogeneous OC precursors (OCP). As OCP heterogeneity can be phenotyped by fusogenic potential (multinucleated master fusogens vs. mononuclear OCP donors) we hypothesized that DC-STAMP, a 7-transmembrane protein receptor required for OCP fusion, mediates this heterogeneity. To test this we evaluated the expression of fusogenic genes and the fusogenic potential of DC-STAMPhi vs. DC-STAMPlo OCP after culture with RANKL. We also evaluated DC-STAMP as an OCP biomarker in patients with inflammatory-erosive psoriatic arthritis (PsA). Although the DC-STAMP ligand remains unknown, this RANKL-induced factor delivers a critical signal to DC-STAMPhi mononuclear OCP, which induces the expression of genes involved in cell fusion while down-regulating DC-STAMP surface expression. The resulting DC-STAMPlo OCP are “master fusogens” that express higher levels of OC markers and pseudopods that seek out and attach to DC-STAMPhi OCP to form multinucleated OC. The higher frequency of DC-STAMP+ cells among PsA patients versus healthy controls suggests that DC-STAMP surface expression on PBMC, prior to RANKL exposure, may be a dynamic biomarker to assess the aggressiveness of erosive arthritis.
honor Melville A. Hare Distinction in Research Award for PhD thesis in Microbiology and Immunology
Yale School of Medicine AwardUniversity of Rochester School of Medicine and DentistryDetails01/01/2009United States
News
News
- October 09, 2018
Kudos
- November 06, 2017
Rheumatology Section News - November 2017