Dynamic biaxial loading of vascular smooth muscle cell seeded tissue equivalents
Paukner D, Jennings I, Cyron C, Humphrey J. Dynamic biaxial loading of vascular smooth muscle cell seeded tissue equivalents. Journal Of The Mechanical Behavior Of Biomedical Materials 2024, 157: 106639. PMID: 38970943, DOI: 10.1016/j.jmbbm.2024.106639.Peer-Reviewed Original ResearchCyclic loadingBiaxial loading conditionsPeriod of cyclic loadingStudy cell-matrix interactionsLoad amplitudeUniaxial experimentsDynamic loadingBiaxial forceCruciform samplesLoading conditionsExternal loadMechanical stateBoundary conditionsLoadExtracellular matrixInfluence cell phenotypeMechanical constraintsRange of forcesCell-matrix interactionsCollagen gelsTissue equivalentsForceSynthetic cellsLoad in vivoVascular smooth muscle cellsMultiscale computational model of aortic remodeling following postnatal disruption of TGFβ signaling
Estrada A, Irons L, Tellides G, Humphrey J. Multiscale computational model of aortic remodeling following postnatal disruption of TGFβ signaling. Journal Of Biomechanics 2024, 169: 112152. PMID: 38763809, PMCID: PMC11141772, DOI: 10.1016/j.jbiomech.2024.112152.Peer-Reviewed Original ResearchAdult aortaTGFB signalingSmooth muscle cellsAortic remodelingCardiac-inducedMouse modelNormal mechanical loadingMuscle cellsPostnatal developmentHemodynamic loadNormal loadAortaMechanical homeostasisMechanical loadingMultiscale computational modelIncreasing loadLoadCell signalingGene productsStructural integrityHemodynamics and Wall Mechanics of Vascular Graft Failure
Szafron J, Heng E, Boyd J, Humphrey J, Marsden A. Hemodynamics and Wall Mechanics of Vascular Graft Failure. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 1065-1085. PMID: 38572650, PMCID: PMC11043008, DOI: 10.1161/atvbaha.123.318239.Peer-Reviewed Original ResearchConceptsVascular graftsTissue-engineered vascular graftsWall mechanicsSolid mechanicsVascular graft failureLoad magnitudeMechanobiological processesLoadMechanobiological stimuliMechanosensitive signaling pathwaysBiomechanical stateWallGraft failureBiomechanical loadingCongenital heart surgeryCoronary artery bypass graftingEnd-organ dysfunctionGraft materialArtery bypass graftingFeedback loopComputational tools