Ruizheng Ernest Sun, MB
he/him/his
About
Research
Overview
Medical Research Interests
Gastrointestinal Diseases; Gastrointestinal Microbiome
Publications
2024
A nomogram combining neutrophil to lymphocyte ratio (NLR) and prognostic nutritional index (PNI) to predict distant metastasis in gastric cancer
Liu J, Sun R, Cai K, Xu Y, Yuan W. A nomogram combining neutrophil to lymphocyte ratio (NLR) and prognostic nutritional index (PNI) to predict distant metastasis in gastric cancer. Scientific Reports 2024, 14: 15391. PMID: 38965325, PMCID: PMC11224267, DOI: 10.1038/s41598-024-65307-7.Peer-Reviewed Original ResearchConceptsNeutrophil-to-lymphocyte ratioPrognostic nutritional indexPlatelet-to-lymphocyte ratioSystemic immune-inflammatory indexLymphocyte to monocyte ratioMultivariate logistic regression analysisDistant metastasisLogistic regression analysisLymphocyte ratioReceiver operating characteristicGastric cancerValidation cohortPredictive factorsRisk factors of distant metastasisDistant metastasis of gastric cancerNutritional indexImmune-inflammatory indexClinical practiceNomogram's predictive performanceDecision curve analysisGastric cancer patientsMetastasis of gastric cancerEfficient nomogramRegression analysisMonocyte ratioHyperbaric oxygen therapy ameliorates intestinal and systematic inflammation by modulating dysbiosis of the gut microbiota in Crohn’s disease
Li Y, Sun R, Lai C, Liu K, Yang H, Peng Z, Xu D, Huang F, Tang K, Peng Y, Liu X. Hyperbaric oxygen therapy ameliorates intestinal and systematic inflammation by modulating dysbiosis of the gut microbiota in Crohn’s disease. Journal Of Translational Medicine 2024, 22: 518. PMID: 38816750, PMCID: PMC11137967, DOI: 10.1186/s12967-024-05317-1.Peer-Reviewed Original ResearchConceptsGut microbiotaFecal microbiota transplantationHyperbaric oxygen therapyDysbiosis of gut microbiotaComposition of gut microbiotaC-reactive proteinCrohn's Disease Activity IndexRegulating gut microbiotaHost physiological conditionAbundance of EscherichiaDisease activity indexCrohn's diseaseClostridium XIVaModulating dysbiosisGene sequencesSystematic inflammationMicrobial diversityOxygen therapyPatients treated with hyperbaric oxygen therapyMicrobiotaColitis mouse modelLevels of C-reactive proteinMicrobiota transplantationSerum C-reactive proteinEffect of hyperbaric oxygen therapyMetagenomic analysis of the intestinal microbiome reveals the potential mechanism involved in Bacillus amyloliquefaciens in treating schistosomiasis japonica in mice
Chen H, Huang S, Zhao Y, Sun R, Wang J, Yao S, Huang J, Yu Z. Metagenomic analysis of the intestinal microbiome reveals the potential mechanism involved in Bacillus amyloliquefaciens in treating schistosomiasis japonica in mice. Microbiology Spectrum 2024, 12: e03735-23. PMID: 38441977, PMCID: PMC10986500, DOI: 10.1128/spectrum.03735-23.Peer-Reviewed Original ResearchConceptsTaxonomic compositionGut microbiomeIntestinal microbiomeFunctional genesKEGG OrthologyMetagenomic analysisIntestinal microbiotaRegulatory mechanismsFunction of gut microbiomeComposition of gut microbiotaAbundance of functional genesMetagenomic sequencingGene functionGut microbiotaPotential regulatory mechanismSpecies levelIntervention of probioticsBacillus amyloliquefaciensMicrobiomeGenesMicrobiotaHost immune responseProbiotic interventionMetabolic reactionsSchistosoma japonicum</i>
2023
Caprini risk assessment model combined with D-dimer to predict the occurrence of deep vein thrombosis and guide intervention after laparoscopic radical resection of colorectal cancer
Zhang W, Sun R, Hu X, Chen Z, Lai C. Caprini risk assessment model combined with D-dimer to predict the occurrence of deep vein thrombosis and guide intervention after laparoscopic radical resection of colorectal cancer. World Journal Of Surgical Oncology 2023, 21: 299. PMID: 37735407, PMCID: PMC10512522, DOI: 10.1186/s12957-023-03183-7.Peer-Reviewed Original ResearchConceptsCaprini risk assessment modelLow-molecular-weight heparinLaparoscopic radical resection of colorectal cancerResection of colorectal cancerRadical resection of colorectal cancerLaparoscopic radical resectionLMWH groupD-dimerDeep vein thrombosisCut-off valueVein thrombosisROC curveColorectal cancerIPC groupClinical data of patientsLow incidence of thrombosisOccurrence of deep vein thrombosisAccurate risk stratificationDecision curve analysisData of patientsColorectal cancer patientsIncidence of thrombosisIncidence of DVTMolecular weight heparinArea under the ROC curveExploring the Plasticity of Diet on Gut Microbiota and Its Correlation with Gut Health
Yao S, Zhao Y, Chen H, Sun R, Chen L, Huang J, Yu Z, Chen S. Exploring the Plasticity of Diet on Gut Microbiota and Its Correlation with Gut Health. Nutrients 2023, 15: 3460. PMID: 37571397, PMCID: PMC10420685, DOI: 10.3390/nu15153460.Peer-Reviewed Original ResearchConceptsGut microbiotaGut healthComposition of gut microbiotaGut microbiota of miceProtecting gut healthRRNA gene sequencesMicrobiota of miceGut microbiota changesGene sequencesAlpha diversityHigh fiber dietMicrobiota changesPathogenic bacteriaMicrobiotaGutGenusHigh-protein dietSwitching dietsDietary impactExperimental timeframeBacteriaProbioticsHigh-protein diet groupSequenceAIN-93G dietGastrointestinal: A case of IgG4‐related disease involving intestinal tract and orbital cavity
Lai C, Sun R, Zhang W, Peng Y. Gastrointestinal: A case of IgG4‐related disease involving intestinal tract and orbital cavity. Journal Of Gastroenterology And Hepatology 2023, 38: 1865-1865. PMID: 37340618, DOI: 10.1111/jgh.16254.Peer-Reviewed Original ResearchBacillus amyloliquefaciens alleviates the pathological injuries in mice infected with Schistosoma japonicum by modulating intestinal microbiome
Chen H, Sun R, Wang J, Yao S, Batool S, Yu Z, Huang S, Huang J. Bacillus amyloliquefaciens alleviates the pathological injuries in mice infected with Schistosoma japonicum by modulating intestinal microbiome. Frontiers In Cellular And Infection Microbiology 2023, 13: 1172298. PMID: 37265494, PMCID: PMC10230073, DOI: 10.3389/fcimb.2023.1172298.Peer-Reviewed Original ResearchConceptsIntestinal microbiomeAbundances of potential pathogenic bacteriaRecovery of diversityRRNA gene sequencesPotential pathogenic bacteriaPathological organ damageEscherichia-ShigellaGene sequencesInteraction networkMammalian hostsBacillus amyloliquefaciensPathogenic bacteriaMicrobiomeIntestinal microenvironmentEffective therapeutic agentSchistosoma japonicumEcological and dynamic analysis of gut microbiota in the early stage of azomethane-dextran sodium sulfate model in mice
Sun R, Chen H, Yao S, Yu Z, Lai C, Huang J. Ecological and dynamic analysis of gut microbiota in the early stage of azomethane-dextran sodium sulfate model in mice. Frontiers In Cellular And Infection Microbiology 2023, 13: 1178714. PMID: 37153156, PMCID: PMC10157258, DOI: 10.3389/fcimb.2023.1178714.Peer-Reviewed Original Research
2022
A novel 7 RNA-based signature for prediction of prognosis and therapeutic responses of wild-type BRAF cutaneous melanoma
Sun R, Liu Y, Lei C, Tang Z, Lu L. A novel 7 RNA-based signature for prediction of prognosis and therapeutic responses of wild-type BRAF cutaneous melanoma. Biological Procedures Online 2022, 24: 7. PMID: 35751033, PMCID: PMC9233353, DOI: 10.1186/s12575-022-00170-2.Peer-Reviewed Original ResearchCutaneous melanomaLack of therapeutic optionsPrediction of prognosisHigh-risk groupBackgroundThe prognosisMalignancy of cancerTherapeutic optionsTherapeutic responseClinical factorsPrognosisCellular proliferationClinical practicePatientsPI3K/AKT/mTOR pathwayTCGA databaseMelanomaUp-regulatedFunctional analysisPotential drug targetsMolecular mechanismsBioinformatic evidenceDrug targetsRNA splicingDownregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer
Li Y, Gan Y, Liu J, Li J, Zhou Z, Tian R, Sun R, Liu J, Xiao Q, Li Y, Lu P, Peng Y, Peng Y, Shu G, Yin G. Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer. Signal Transduction And Targeted Therapy 2022, 7: 87. PMID: 35351858, PMCID: PMC8964798, DOI: 10.1038/s41392-022-00902-6.Peer-Reviewed Original ResearchConceptsOxaliplatin resistanceColorectal cancerTumor growthMEIS1 expressionCell sensitivity to oxaliplatinPreventing DNA damage repairCombination of oxaliplatinSurvival of CRC patientsTreatment of colorectal cancerSensitivity to oxaliplatinEZH2 inhibitor GSK126Suppressed tumor growthReverse oxaliplatin resistanceFrontline treatmentAcquired resistanceCRC patientsInhibitor GSK126OxaliplatinFEN1 expressionTherapeutic strategiesDNA damage repairELFN1-AS1Cell survivalMeis1Patients
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