Ruizheng Ernest Sun, MB
he/him/his
M.D. Candidate, Microbial PathogenesisDownloadHi-Res Photo
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M.D. Candidate, Microbial Pathogenesis
Biography
Ruizheng (Ernest) Sun is a long-term M.D. candidate from Xiangya School of Medicine, Central South University. He is currently participating in the Yale PALS program in Dr. Andrew Goodman's lab at Yale Microbial Sciences Institute. His research interests are how drugs modulate the interactions between the host and the microbiome and affect digestive health.
Last Updated on January 16, 2025.
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Education & Training
- MB
- Xiangya School of Medicine (2022)
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Overview
Medical Research Interests
Gastrointestinal Diseases; Gastrointestinal Microbiome
ORCID
0000-0003-4826-5000- View Lab Website
Goodman Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Ruizheng Ernest Sun's published research.
Publications Timeline
A big-picture view of Ruizheng Ernest Sun's research output by year.
Research Interests
Research topics Ruizheng Ernest Sun is interested in exploring.
Andrew Goodman, PhD
Noah Wolcott Palm, PhD
15Publications
395Citations
Gastrointestinal Microbiome
Publications
2025
Identification of medication–microbiome interactions that affect gut infection
Kumar A, Sun R, Habib B, Deng T, Bencivenga-Barry N, Palm N, Ivanov I, Tamblyn R, Goodman A. Identification of medication–microbiome interactions that affect gut infection. Nature 2025, 644: 506-515. PMID: 40670788, DOI: 10.1038/s41586-025-09273-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEnterica serovar TyphimuriumSalmonella enterica subspRisk of infectionEffect of digoxin treatmentSerovar TyphimuriumS. TmGut microbiomeMicrobiome compositionRisk of gastrointestinal infectionsInvading pathogensMicrobiomeCardiac glycoside digoxinNon-antibioticGut infectionImmune surveillanceDigoxin treatmentGastrointestinal infectionsB-defensinsGutInfectionEpidemiological studiesPopulation cohortDrugExperimental approachRisk
2024
A nomogram combining neutrophil to lymphocyte ratio (NLR) and prognostic nutritional index (PNI) to predict distant metastasis in gastric cancer
Liu J, Sun R, Cai K, Xu Y, Yuan W. A nomogram combining neutrophil to lymphocyte ratio (NLR) and prognostic nutritional index (PNI) to predict distant metastasis in gastric cancer. Scientific Reports 2024, 14: 15391. PMID: 38965325, PMCID: PMC11224267, DOI: 10.1038/s41598-024-65307-7.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsNeutrophil-to-lymphocyte ratioPrognostic nutritional indexPlatelet-to-lymphocyte ratioSystemic immune-inflammatory indexLymphocyte to monocyte ratioMultivariate logistic regression analysisDistant metastasisLogistic regression analysisLymphocyte ratioReceiver Operating CharacteristicGastric cancerValidation cohortPredictive factorsRisk factors of distant metastasisDistant metastasis of gastric cancerNutritional indexImmune-inflammatory indexClinical practiceNomogram's predictive performanceDecision curve analysisGastric cancer patientsMetastasis of gastric cancerEfficient nomogramRegression analysisMonocyte ratioHyperbaric oxygen therapy ameliorates intestinal and systematic inflammation by modulating dysbiosis of the gut microbiota in Crohn’s disease
Li Y, Sun R, Lai C, Liu K, Yang H, Peng Z, Xu D, Huang F, Tang K, Peng Y, Liu X. Hyperbaric oxygen therapy ameliorates intestinal and systematic inflammation by modulating dysbiosis of the gut microbiota in Crohn’s disease. Journal Of Translational Medicine 2024, 22: 518. PMID: 38816750, PMCID: PMC11137967, DOI: 10.1186/s12967-024-05317-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGut microbiotaFecal microbiota transplantationHyperbaric oxygen therapyDysbiosis of gut microbiotaComposition of gut microbiotaC-reactive proteinCrohn's Disease Activity IndexRegulating gut microbiotaHost physiological conditionAbundance of EscherichiaDisease activity indexCrohn's diseaseClostridium XIVaModulating dysbiosisGene sequencesSystematic inflammationMicrobial diversityOxygen therapyPatients treated with hyperbaric oxygen therapyMicrobiotaColitis mouse modelLevels of C-reactive proteinMicrobiota transplantationSerum C-reactive proteinEffect of hyperbaric oxygen therapyMetagenomic analysis of the intestinal microbiome reveals the potential mechanism involved in Bacillus amyloliquefaciens in treating schistosomiasis japonica in mice
Chen H, Huang S, Zhao Y, Sun R, Wang J, Yao S, Huang J, Yu Z. Metagenomic analysis of the intestinal microbiome reveals the potential mechanism involved in Bacillus amyloliquefaciens in treating schistosomiasis japonica in mice. Microbiology Spectrum 2024, 12: e03735-23. PMID: 38441977, PMCID: PMC10986500, DOI: 10.1128/spectrum.03735-23.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsTaxonomic compositionGut microbiomeIntestinal microbiomeFunctional genesKEGG OrthologyMetagenomic analysisIntestinal microbiotaRegulatory mechanismsFunction of gut microbiomeComposition of gut microbiotaAbundance of functional genesMetagenomic sequencingGene functionGut microbiotaPotential regulatory mechanismSpecies levelIntervention of probioticsBacillus amyloliquefaciensMicrobiomeGenesMicrobiotaHost immune responseProbiotic interventionMetabolic reactionsSchistosoma japonicum
2023
Caprini risk assessment model combined with D-dimer to predict the occurrence of deep vein thrombosis and guide intervention after laparoscopic radical resection of colorectal cancer
Zhang W, Sun R, Hu X, Chen Z, Lai C. Caprini risk assessment model combined with D-dimer to predict the occurrence of deep vein thrombosis and guide intervention after laparoscopic radical resection of colorectal cancer. World Journal Of Surgical Oncology 2023, 21: 299. PMID: 37735407, PMCID: PMC10512522, DOI: 10.1186/s12957-023-03183-7.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCaprini risk assessment modelLow-molecular-weight heparinLaparoscopic radical resection of colorectal cancerResection of colorectal cancerRadical resection of colorectal cancerLaparoscopic radical resectionLMWH groupD-dimerDeep vein thrombosisCut-off valueVein thrombosisROC curveColorectal cancerIPC groupClinical data of patientsLow incidence of thrombosisOccurrence of deep vein thrombosisAccurate risk stratificationDecision curve analysisData of patientsColorectal cancer patientsIncidence of thrombosisIncidence of DVTMolecular weight heparinArea under the ROC curveExploring the Plasticity of Diet on Gut Microbiota and Its Correlation with Gut Health
Yao S, Zhao Y, Chen H, Sun R, Chen L, Huang J, Yu Z, Chen S. Exploring the Plasticity of Diet on Gut Microbiota and Its Correlation with Gut Health. Nutrients 2023, 15: 3460. PMID: 37571397, PMCID: PMC10420685, DOI: 10.3390/nu15153460.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGut microbiotaGut healthComposition of gut microbiotaGut microbiota of miceProtecting gut healthRRNA gene sequencesMicrobiota of miceGut microbiota changesGene sequencesAlpha diversityHigh fiber dietMicrobiota changesPathogenic bacteriaMicrobiotaGutGenusHigh-protein dietSwitching dietsDietary impactExperimental timeframeBacteriaProbioticsHigh-protein diet groupSequenceAIN-93G dietGastrointestinal: A case of IgG4‐related disease involving intestinal tract and orbital cavity
Lai C, Sun R, Zhang W, Peng Y. Gastrointestinal: A case of IgG4‐related disease involving intestinal tract and orbital cavity. Journal Of Gastroenterology And Hepatology 2023, 38: 1865-1865. PMID: 37340618, DOI: 10.1111/jgh.16254.Peer-Reviewed Original ResearchCitationsBacillus amyloliquefaciens alleviates the pathological injuries in mice infected with Schistosoma japonicum by modulating intestinal microbiome
Chen H, Sun R, Wang J, Yao S, Batool S, Yu Z, Huang S, Huang J. Bacillus amyloliquefaciens alleviates the pathological injuries in mice infected with Schistosoma japonicum by modulating intestinal microbiome. Frontiers In Cellular And Infection Microbiology 2023, 13: 1172298. PMID: 37265494, PMCID: PMC10230073, DOI: 10.3389/fcimb.2023.1172298.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIntestinal microbiomeAbundances of potential pathogenic bacteriaRecovery of diversityRRNA gene sequencesPotential pathogenic bacteriaPathological organ damageEscherichia-ShigellaGene sequencesInteraction networkMammalian hostsBacillus amyloliquefaciensPathogenic bacteriaMicrobiomeIntestinal microenvironmentEffective therapeutic agentSchistosoma japonicumEcological and dynamic analysis of gut microbiota in the early stage of azomethane-dextran sodium sulfate model in mice
Sun R, Chen H, Yao S, Yu Z, Lai C, Huang J. Ecological and dynamic analysis of gut microbiota in the early stage of azomethane-dextran sodium sulfate model in mice. Frontiers In Cellular And Infection Microbiology 2023, 13: 1178714. PMID: 37153156, PMCID: PMC10157258, DOI: 10.3389/fcimb.2023.1178714.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2022
A novel 7 RNA-based signature for prediction of prognosis and therapeutic responses of wild-type BRAF cutaneous melanoma
Sun R, Liu Y, Lei C, Tang Z, Lu L. A novel 7 RNA-based signature for prediction of prognosis and therapeutic responses of wild-type BRAF cutaneous melanoma. Biological Procedures Online 2022, 24: 7. PMID: 35751033, PMCID: PMC9233353, DOI: 10.1186/s12575-022-00170-2.Peer-Reviewed Original ResearchAltmetricConceptsCutaneous melanomaLack of therapeutic optionsPrediction of prognosisHigh-risk groupBackgroundThe prognosisMalignancy of cancerTherapeutic optionsTherapeutic responseClinical factorsPrognosisCellular proliferationClinical practicePatientsPI3K/AKT/mTOR pathwayTCGA databaseMelanomaUp-regulatedFunctional analysisPotential drug targetsMolecular mechanismsBioinformatic evidenceDrug targetsRNA splicing
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West Haven, CT 06516