Randy Luciano, MD, PhD
Associate Professor of MedicineCards
About
Research
Publications
2024
Risk vs. Reward: Impact of Kidney Biopsies on the Management of Critically Ill Patients
Llama A, Sadarangani S, Moledina D, Luciano R. Risk vs. Reward: Impact of Kidney Biopsies on the Management of Critically Ill Patients. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024dd7bnz12. DOI: 10.1681/asn.2024dd7bnz12.Peer-Reviewed Original ResearchThe Case | An active injection drug user with a skin rash and kidney failure
Aron A, Luciano R. The Case | An active injection drug user with a skin rash and kidney failure. Kidney International 2024, 105: 1327-1328. PMID: 38777409, DOI: 10.1016/j.kint.2024.03.009.Peer-Reviewed Original ResearchIdentification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2024, 134: e180583. PMID: 38488004, PMCID: PMC10940080, DOI: 10.1172/jci180583.Peer-Reviewed Original ResearchRationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis
Barsotti G, Luciano R, Kumar A, Meliambro K, Kakade V, Tokita J, Naik A, Fu J, Peck E, Pell J, Reghuvaran A, Tanvir E, Patel P, Zhang W, Li F, Moeckel G, Perincheri S, Cantley L, Moledina D, Wilson F, He J, Menon M. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis. Kidney International Reports 2024, 9: 1354-1368. PMID: 38707807, PMCID: PMC11068976, DOI: 10.1016/j.ekir.2024.02.006.Peer-Reviewed Original ResearchMinimal change diseaseRandomized controlled trialsSafety of metforminDouble-blindPodocyte injuryAdjunctive therapyPlacebo-controlled randomized controlled trialsPhase III studyPhase II trialPrimary glomerular diseaseFocal segmental glomerulosclerosisEffect of metforminPhase IIPlacebo-controlledPreclinical dataNovel urineChange diseaseTissue markersRandomized trialsSegmental glomerulosclerosisGlomerular diseaseMechanistic biomarkersObservational studyFSGSInexpensive agent
2023
Guillain-Barre Syndrome Presenting Alongside Lupus Nephritis: Case and Management
Mehta P, Luciano R, Aklilu A, Malvar G. Guillain-Barre Syndrome Presenting Alongside Lupus Nephritis: Case and Management. Journal Of The American Society Of Nephrology 2023, 34: 277-277. DOI: 10.1681/asn.20233411s1277a.Peer-Reviewed Original ResearchDiffuse Alveolar Hemorrhage Presenting in IgA Nephropathy
Jobson C, Luciano R, Shirali A, Malvar G. Diffuse Alveolar Hemorrhage Presenting in IgA Nephropathy. Journal Of The American Society Of Nephrology 2023, 34: 1119-1119. DOI: 10.1681/asn.20233411s11119a.Peer-Reviewed Original ResearchIdentification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2023, 133: e168950. PMID: 37395276, PMCID: PMC10313360, DOI: 10.1172/jci168950.Peer-Reviewed Original ResearchConceptsUrinary CXCL9External validation cohortValidation cohortControl groupAIN diagnosisDiscovery cohortKidney tissueDiagnostic biomarkersAcute interstitial nephritisCXCL9 mRNA expressionAcute kidney injuryBiopsy-confirmed diagnosisAvailable clinical testsNational InstituteKidney injuryTubulointerstitial nephritisInterstitial nephritisKidney biopsyHistological confirmationHistological diagnosisTreatment optionsLymphocyte chemotaxisCXCL9MRNA expression differencesPatients
2022
Safety and Adequacy of Kidney Biopsy Procedure in Patients with Obesity
Qian L, Menez S, Hu D, Weinstein J, Melchinger H, Thiessen-Philbrook H, Luciano R, Turner J, Perazella M, Villalobos C, Shaw M, Wilson F, Parikh C, Moledina D. Safety and Adequacy of Kidney Biopsy Procedure in Patients with Obesity. Kidney360 2022, 4: 98-101. PMID: 36700910, PMCID: PMC10101611, DOI: 10.34067/kid.0006602022.Peer-Reviewed Original ResearchAA Amyloidosis Presenting With Renal Amyloidoma
Gunasekaran D, Luciano R. AA Amyloidosis Presenting With Renal Amyloidoma. Journal Of The American Society Of Nephrology 2022, 33: 167-168. DOI: 10.1681/asn.20223311s1167e.Peer-Reviewed Original ResearchPeritoneal Dialysis Should Be Considered the First Option for Patients Requiring Urgent Start Dialysis: CON
Luciano R. Peritoneal Dialysis Should Be Considered the First Option for Patients Requiring Urgent Start Dialysis: CON. Kidney360 2022, 4: 138-140. PMID: 36821605, PMCID: PMC10103267, DOI: 10.34067/kid.0007822021.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Treating Kidney Disease in Patients with APOL1
HIC ID2000030942RoleSub InvestigatorPrimary Completion Date05/31/2026Recruiting ParticipantsGenderBothAge18 years - 60 years
Academic Achievements & Community Involvement
Clinical Care
Overview
Randy Luciano, MD, PhD, has expertise in treating patients with glomerular disease (a kind of kidney disease that affects the filtering aspect of the kidney) and kidney-related vasculitis. Additionally, Dr. Luciano treats patients with, but not limited to, minimal change disease, membranous nephropathy, FSGS, renal amyloidosis, Lupus nephritis, IgA nephropathy, and ANCA mediated vasculitis. He is directly involved in the diagnosis (through biopsy) and treatment of patients with glomerular disease. In addition, he coordinates several clinical trials to help further progress the treatment options for these diseases.
Clinical Specialties
Nephrology; Rheumatology
Fact Sheets
Polycystic Kidney Disease (PKD)
Learn More on Yale MedicineGlomerulonephritis
Learn More on Yale MedicineDiagnosing Lupus Nephritis
Learn More on Yale MedicineAcute Kidney Injury (AKI)
Learn More on Yale Medicine
Board Certifications
Nephrology
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2019
- Original Certification Date
- 2013
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2011
Yale Medicine News
News
News
- April 25, 2024Source: Yale Medicine
Why Is Chronic Kidney Disease (CKD) on the Rise? 6 Things to Know
- September 14, 2023
Smilow Shares: AL Amyloidosis
- February 15, 2023
Discoveries & Impact (February 2023)
- November 02, 2022
ASN Kidney Week 2022: Presentations from Yale Nephrology
Get In Touch
Contacts
Appointment Number
Administrative Support
Locations
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.