Aurélien Justet

2025

• From spatial transcriptomics to mouse model: the (re-)emergence of ductal myofibroblasts as a new cellular target in idiopathic pulmonary fibrosis

  Justet A, Schupp J. From spatial transcriptomics to mouse model: the (re-)emergence of ductal myofibroblasts as a new cellular target in idiopathic pulmonary fibrosis. European Respiratory Journal 2025, 66: 2501466. PMID: 41057218, DOI: 10.1183/13993003.01466-2025.

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• Single-cell analysis of cryobiopsy samples from patients with early IPF reveals loss of alveolar epithelial cells, and emergence of aberrant basaloid cells

  Justet A, Adams T, Khoury J, Balayev A, Schupp J, Manning E, Zhao A, Ahangari F, Yan X, Ravaglia C, Poletti V, Tomasseti S, Kaminski N. Single-cell analysis of cryobiopsy samples from patients with early IPF reveals loss of alveolar epithelial cells, and emergence of aberrant basaloid cells. 2025, oa1196. DOI: 10.1183/13993003.congress-2025.oa1196.

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• The PPFE atlas reveals distinct profibrotic and elastotic mesenchymal cellular archetypes in pleuroparenchymal fibroelastosis

  Ruwisch J, Cazes A, Leiber L, Borie R, Christian L, Mal H, Langer L, De Montpréville V, Kamp J, Greer M, Wrede C, Hegermann J, Gottlieb J, Seeliger B, Bernaudin J, Knudsen L, Mordant P, Neubert L, Crestani B, Prasse A, Kaminski N, Justet A, Schupp J. The PPFE atlas reveals distinct profibrotic and elastotic mesenchymal cellular archetypes in pleuroparenchymal fibroelastosis. 2025, oa4324. DOI: 10.1183/13993003.congress-2025.oa4324.

  Peer-Reviewed Original Research

• Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models

  Wagner D, Alsafadi H, Mitash N, Justet A, Hu Q, Pineda R, Staab-Weijnitz C, Korfei M, Gvazava N, Wannemo K, Onwuka U, Mozurak M, Estrada-Bernal A, Cala-Garcia J, Mutze K, Costa R, Bölükbas D, Stegmayr J, Skronska-Wasek W, Klee S, Ota C, Baarsma H, Wang J, Sembrat J, Hilgendorff A, Ding J, Günther A, Chambers R, Rosas I, de Langhe S, Kaminski N, Lehmann M, Eickelberg O, Königshoff M. Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models. Nature Communications 2025, 16: 7099. PMID: 40753090, PMCID: PMC12318044, DOI: 10.1038/s41467-025-61795-x.

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• A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases

  Zheng Y, Schupp J, Adams T, Clair G, Justet A, Ahangari F, Yan X, Hansen P, Carlon M, Cortesi E, Vermant M, Vos R, De Sadeleer L, Rosas I, Pineda R, Sembrat J, Königshoff M, McDonough J, Vanaudenaerde B, Wuyts W, Kaminski N, Ding J. A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases. Nature Biomedical Engineering 2025, 9: 2155-2180. PMID: 40542107, PMCID: PMC12705450, DOI: 10.1038/s41551-025-01423-7.

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• Understanding and Reducing Cardiopulmonary Sequelae Associated With Chronic Hypoxia

  Manning E, Ramachandra A, Sharma P, Nikola F, De Man R, Doddaballapur P, Raredon M, Szafron J, Baernthaler T, Justet A, Akingbesote N, Perry R, Adams T, Cavinato C, Yan X, Tellides G, Kaminski N, Humphrey J. Understanding and Reducing Cardiopulmonary Sequelae Associated With Chronic Hypoxia. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a3336-a3336. DOI: 10.1164/ajrccm.2025.211.abstracts.a3336.

  Peer-Reviewed Original Research

• The Potential Role of miR205 and miR205HG in Pulmonary Fibrosis

  Anderson S, Johad K, Ahangari F, Justet A, Adams T, Yan X, Kaminski N. The Potential Role of miR205 and miR205HG in Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a4662-a4662. DOI: 10.1164/ajrccm.2025.211.abstracts.a4662.

  Peer-Reviewed Original Research

• The PPFE Cell Atlas - The Discovery of the Usual Fibrotic Niche at the Edge of Pleuro-Parenchymal Fibroelastotic Remodeling Surprises as an Immune Cell Driven Phenomenon

  Ruwisch J, Cazes A, leiber L, Borie R, Leonhard C, Mal H, Langer L, de Montpréville V, Kamp J, Greer M, Wrede C, Hegermann J, Artysh N, Gottlieb J, Seeliger B, Bernaudin J, Knudsen L, Mordant P, Neubert L, Crestani B, Prasse A, Kaminski N, Justet A, Schupp J. The PPFE Cell Atlas - The Discovery of the Usual Fibrotic Niche at the Edge of Pleuro-Parenchymal Fibroelastotic Remodeling Surprises as an Immune Cell Driven Phenomenon. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a5272-a5272. DOI: 10.1164/ajrccm.2025.211.abstracts.a5272.

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• Early IPF Is Characterized by a Dramatic Shift of the Epithelial and Endothelial Populations Within the Alveolar Niche

  Justet A, Adams T, Khoury J, Balayev A, Abu Hussein N, Schupp J, Zhao A, Manning E, Ahangari F, Yan X, Ravaglia C, Tomassetti S, Poletti V, Kaminski N. Early IPF Is Characterized by a Dramatic Shift of the Epithelial and Endothelial Populations Within the Alveolar Niche. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7109-a7109. DOI: 10.1164/ajrccm.2025.211.abstracts.a7109.

  Peer-Reviewed Original Research

• The Potential Role of GPR87 in the Development of Pulmonary Fibrosis

  Khoury J, Ahangari F, Justet A, Adams T, Manning E, Mcdonough J, Anderson S, Nekola F, Beermann M, Bauer Y, Gomez J, Kaminski N. The Potential Role of GPR87 in the Development of Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7110-a7110. DOI: 10.1164/ajrccm.2025.211.abstracts.a7110.

  Peer-Reviewed Original Research