Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsThomas Prebet, MD, PhD
Associate Professor AdjunctDownloadHi-Res Photo
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Titles
Associate Professor Adjunct
Biography
After completing his doctorate in medical hematology and oncology in Lyon, France, Dr. Prebet joined Institut Paoli-Calmettes in Marseille, France and completed a fellowship in Johns Hopkins University (Baltimore, MA, USA) as a Fullbright alumni. Dr. Prebet is currently the director of the inpatient hematology unit and the medical director of the hematology division of Yale Clinical Trial Office. He is the associate director of the myeloid malignancies program in the hematology department of the Yale Cancer Center, New haven, CT. He is developing myeloid malignancies clinical trials and translational works for advanced phase acute myeloid leukemia and myelodysplastics syndromes. The current works gave the basis for defining demethylating agent failure outcome (Prebet JCO 2011, Hematologica 2012, British Journal of Hematology 2012, Blood Advance 2018), contributed to his knowledge of combinations therapies based on HDAC inhibitors (Prebet JCO 2014, Prebet Leuk Res 2014) and gave the first insights on the implication of Wnt non canonical pathway in acute myeloid leukemia (Prebet Blood 2011). Dr Prebet is the coordinating investigator of several clinical trials for myelodysplastic syndromes and acute leukemia patients and contributed to 110 peer reviewed manuscript.
Last Updated on February 11, 2025.
Appointments
Medical Oncology and Hematology
Associate Professor AdjunctPrimary
Other Departments & Organizations
- Hematology
- Internal Medicine
- Medical Oncology and Hematology
- Yale Medicine
- Yale New Haven Health System
Education & Training
- Post-Doctoral Fellow
- Johns Hopkins University (2010)
- PhD
- Centre de Recherche en Cancerologie (2009)
- MS
- Claude Bernard University (2005)
- Resident
- University Hospitals of Lyon (2004)
- MD
- Montpellier University (2000)
Research
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Overview
Medical Research Interests
Hematology; Leukemia; Myelodysplastic Syndromes
ORCID
0000-0002-6872-625X
Research at a Glance
Yale Co-Authors
Frequent collaborators of Thomas Prebet's published research.
Publications Timeline
A big-picture view of Thomas Prebet's research output by year.
Research Interests
Research topics Thomas Prebet is interested in exploring.
Amer Zeidan, MBBS, MD
15Publications
957Citations
Myelodysplastic Syndromes
Publications
2026
CPX-351 Selectively Benefits Patients with AML and Myelodysplasia-Related Mutations in the Pivotal Randomized Trial
Shimony S, Murdock H, Keating J, Tsai H, Sasi A, Gibson C, Faderl S, Wagner A, Dronamraju N, Lin T, Prebet T, Cortes J, Uy G, Lancet J, Reilly C, Neuberg D, Stone R, Lindsley R. CPX-351 Selectively Benefits Patients with AML and Myelodysplasia-Related Mutations in the Pivotal Randomized Trial. Blood Advances 2026 PMID: 41628350, DOI: 10.1182/bloodadvances.2025019378.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAcute myeloid leukemiaCPX-351Copy-neutral lossOS benefitOverall survivalMyelodysplasia-related acute myeloid leukemiaTherapy-related acute myeloid leukemiaRandomized trialsCopy-neutral loss of heterozygosityTreatment of acute myeloid leukemiaTwo-year OSWHO 5th EditionMyelodysplasia-related changesLoss of heterozygosityAssociated with survivalAML-MRCPrognostic factorsAML subgroupsMyeloid leukemiaMolecular subgroupsGene mutationsMultivariate analysisPatientsBenefit patientsSurvival
2025
Oral azacitidine maintenance therapy for patients with acute myeloid leukaemia and myelodysplasia‐related changes: Post hoc analysis of the QUAZAR AML‐001 trial
Voso M, de Botton S, Pfeilstöcker M, Alvarez A, Wang K, See W, Guerrero M, de Menezes D, Petrlik E, Prebet T, Roboz G. Oral azacitidine maintenance therapy for patients with acute myeloid leukaemia and myelodysplasia‐related changes: Post hoc analysis of the QUAZAR AML‐001 trial. British Journal Of Haematology 2025, 208: 746-751. PMID: 41387169, DOI: 10.1111/bjh.70272.Peer-Reviewed Original ResearchCitationsMeasurable residual disease (MRD) as a surrogate end point for clinical drug approval in acute myeloid leukemia (AML): Perspectives from the MRD Partnership and Alliance in AML Clinical Treatment Consortium
Boyiadzis M, Wei A, Paiva B, Freeman S, Kaspers G, Chyla B, Hersey S, Patel R, Maloney B, Zumofen M, Van Hoef M, Wulff B, Obourn V, Patel S, de Menezes D, Shi Q, Bengoudifa B, Dimier N, Prior T, Roboz G, Prebet T. Measurable residual disease (MRD) as a surrogate end point for clinical drug approval in acute myeloid leukemia (AML): Perspectives from the MRD Partnership and Alliance in AML Clinical Treatment Consortium. Cancer 2025, 131: e35960. PMID: 40576165, PMCID: PMC12203635, DOI: 10.1002/cncr.35960.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsMeasurable residual diseaseAcute myeloid leukemiaSurrogate end pointsEnd pointsClinical trialsResidual diseaseMyeloid leukemiaClinical trial end pointsAcute myeloid leukemia therapyTrial end pointsAssessment of disease burdenAcute myeloid leukemia clinical trialsUnmet medical needMRD assessmentOverall survivalImproved survivalPatient subgroupsTherapeutic decisionsPatient groupPatientsPatient outcomesClinical treatmentAssessment timepointsDisease burdenDrug approvalReal‐world treatment patterns and outcomes with oral azacitidine maintenance therapy in patients with acute myeloid leukemia
Leber B, Ruiz M, Elgendy H, Pettersson F, Prebet T, Vigil C, Parikh R, Korgaonkar S, Bello F, Davis K, Gaugler L, Strocchia M, Sieluk J, Li Y, Schuh A. Real‐world treatment patterns and outcomes with oral azacitidine maintenance therapy in patients with acute myeloid leukemia. Cancer 2025, 131: e35845. PMID: 40233158, DOI: 10.1002/cncr.35845.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute myeloid leukemiaRelapse-free survivalOral-AZAMaintenance therapyMyeloid leukemiaClinical characteristicsTreatment patternsFollow-upSafety outcomes of patientsHematopoietic stem cell transplantationReal-world treatment patternsMedian Follow-UpStem cell transplantationEuropean LeukemiaNet classificationKaplan-Meier methodologyOverall survival outcomesOutcomes of patientsMedical record reviewInclusion of patientsOral azacitidineConsolidation therapyInduction therapyInduction regimensOverall survivalCell transplantation
2024
Oral azacitidine maintenance after intensive chemotherapy versus venetoclax and azacitidine: real world outcomes in newly diagnosed acute myeloid leukemia
Mims A, Xie Z, Potluri R, Rotter D, Chevli M, Prebet T, Gaugler L, Strocchia M, Vasconcelos A, Sieluk J. Oral azacitidine maintenance after intensive chemotherapy versus venetoclax and azacitidine: real world outcomes in newly diagnosed acute myeloid leukemia. Leukemia & Lymphoma 2024, 66: 479-487. PMID: 39606887, DOI: 10.1080/10428194.2024.2425792.Peer-Reviewed Original ResearchConceptsRelapse-free survivalNewly diagnosed acute myeloid leukemiaOral-AZAIntensive chemotherapyAcute myeloid leukemiaOverall survivalMyeloid leukemiaMedian relapse-free survivalFlatiron Health databasePropensity score matched cohortCompare treatment patternsScore-matched cohortAzacitidine maintenanceND-AMLOral azacitidineMedian OSRetrospective studyClinical outcomesTreatment patternsAzacitidineTransplant candidatesPatientsReal-world outcomesRemissionChemotherapyLenalidomide in Transfusion-Dependent IPSS Low- or Intermediate-1-Risk Myelodysplastic Syndromes and Isolated Del(5q): Results of a European Postauthorization Safety Surveillance Study
Poloni A, Raaschou-Jensen K, Mohedo F, Paolini S, Oliva E, Buccisano F, Vasconcelos A, Kim I, Makwana A, Bernasconi D, Rosettani B, Prebet T, Santini V. Lenalidomide in Transfusion-Dependent IPSS Low- or Intermediate-1-Risk Myelodysplastic Syndromes and Isolated Del(5q): Results of a European Postauthorization Safety Surveillance Study. Clinical Lymphoma Myeloma & Leukemia 2024, 25: e131-e142. PMID: 39516085, DOI: 10.1016/j.clml.2024.10.007.Peer-Reviewed Original ResearchCitationsAltmetricConceptsInternational Prognostic Scoring SystemDose of lenalidomideMyelodysplastic syndromeIsolated del(5qAcute myeloid leukemiaBenefit-risk profileSafety populationTransfusion-DependentOverall survivalCumulative incidenceCumulative incidence of acute myeloid leukemiaGrade 3/4 treatment-emergent adverse eventsNon-interventional post-authorization safety studyInternational Prognostic Scoring System low-Intermediate-1-risk myelodysplastic syndromeIncidence of acute myeloid leukemiaLower-risk myelodysplastic syndromesTreatment-emergent adverse eventsEffects of lenalidomidePrognostic scoring systemKaplan-Meier analysisPost-authorization safety studyRoutine careClinical trial dataSafety surveillance studyHealthcare Utilization and Costs Among Patients with Acute Myeloid Leukemia Receiving Oral Azacitidine Maintenance Therapy Versus No Maintenance: A US Claims Database Study
Borate U, Seiter K, Potluri R, Mazumder D, Chevli M, Prebet T, Gaugler L, Strocchia M, Vasconcelos A, Sieluk J. Healthcare Utilization and Costs Among Patients with Acute Myeloid Leukemia Receiving Oral Azacitidine Maintenance Therapy Versus No Maintenance: A US Claims Database Study. Advances In Therapy 2024, 41: 4049-4064. PMID: 39240504, PMCID: PMC11480148, DOI: 10.1007/s12325-024-02947-1.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAcute myeloid leukemiaHealthcare resource utilizationOral-AZAPropensity score matchingMyeloid leukemiaReal-world healthcare resource utilizationClinical practiceHematopoietic stem cell transplantationLower healthcare resource utilizationResultsAfter propensity score matchingStem cell transplantationContinuous insurance enrollmentClaims database studyOutpatient visitsOral azacitidinePost-remissionMaintenance therapyProlonged remissionCell transplantationDisease remissionDelayed relapseBaseline characteristicsTreatment patternsPatientsDatabase studyLuspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): primary analysis of a phase 3, open-label, randomised, controlled trial
Della Porta M, Garcia-Manero G, Santini V, Zeidan A, Komrokji R, Shortt J, Valcárcel D, Jonasova A, Dimicoli-Salazar S, Tiong I, Lin C, Li J, Zhang J, Pilot R, Kreitz S, Pozharskaya V, Keeperman K, Rose S, Prebet T, Lai Y, Degulys A, Paolini S, Cluzeau T, Fenaux P, Platzbecker U. Luspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): primary analysis of a phase 3, open-label, randomised, controlled trial. The Lancet Haematology 2024, 11: e646-e658. PMID: 39038479, DOI: 10.1016/s2352-3026(24)00203-5.Peer-Reviewed Original ResearchCitationsAltmetricConceptsLower-risk myelodysplastic syndromesRed blood cell transfusion independenceTreatment-emergent adverse eventsMedian Follow-UpEpoetin alfa groupMyelodysplastic syndromeLuspatercept groupTransfusion-DependentSerum erythropoietin concentrationPrimary endpointEpoetin alfaTransfusion independenceOpen-labelAlfa groupAdverse eventsFollow-upRed blood cell transfusion burdenErythropoietin concentrationIntention-to-treat populationControlled TrialsCommon grade 3Epoetin alfa recipientsMean haemoglobin increasePrimary analysisProportion of patientsDifferentiation syndrome associated with treatment with IDH2 inhibitor enasidenib: pooled analysis from clinical trials
Montesinos P, Fathi A, de Botton S, Stein E, Zeidan A, Zhu Y, Prebet T, Vigil C, Bluemmert I, Yu X, DiNardo C. Differentiation syndrome associated with treatment with IDH2 inhibitor enasidenib: pooled analysis from clinical trials. Blood Advances 2024, 8: 2509-2519. PMID: 38507688, PMCID: PMC11131052, DOI: 10.1182/bloodadvances.2023011914.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAcute myeloid leukemiaDevelopment of differentiation syndromeRisk factorsPooled analysisIDH2-mutant acute myeloid leukemiaClinical trialsAcute myeloid leukemia populationMedian time to onsetClinical features of DSBone marrow blastsNon-specific symptomsTime to onsetBaseline risk factorsTreatment of DSSymptoms of DSIdentified risk factorsFeatures of DSMarrow blastsSystemic steroidsPulmonary infiltratesClinical responseMutant IDH2 inhibitorMyeloid leukemiaClinical featuresGrade 3Somatic gene mutation patterns and burden influence outcomes with enasidenib in relapsed/refractory IDH2-mutated AML
Risueño A, See W, Bluemmert I, de Botton S, DiNardo C, Fathi A, Schuh A, Montesinos P, Vyas P, Prebet T, Gandhi A, Hasan M. Somatic gene mutation patterns and burden influence outcomes with enasidenib in relapsed/refractory IDH2-mutated AML. Leukemia Research 2024, 140: 107497. PMID: 38564986, DOI: 10.1016/j.leukres.2024.107497.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsConventional care regimensMutational burdenR/R AMLCo-mutationsIDH2-R172Co-mutation patternsAssociated with decreased overall survivalRelapsed/Refractory Acute Myeloid LeukemiaTargeted Next-Generation SequencingAML patient cohortNewly diagnosed AMLLow mutational burdenEvent-free survivalLimited treatment optionsAcute myeloid leukemiaGene mutation patternsIDH2 variantsIDH2 R140Prognostic impactOverall survivalPrognostic relevanceSurvival benefitMyeloid leukemiaIDH2 mutationsPatient cohort
Academic Achievements & Community Involvement
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Activities
activity National Cancer Center Network
10/01/2017 - PresentCommitteesCommittee MemberDetailsAML committeeactivity Yale Human Research Protection Program
12/31/2016 - PresentCommitteesCommittee MemberDetailsHuman Investigation Committeeactivity Via Pathway Oncology
2018 - PresentPeer Review Groups and Grant Study SectionsCo-Chairactivity National Comprehensive Cancer Network
2018 - PresentPeer Review Groups and Grant Study SectionsCommittee Memberactivity Onco Hematology for Fullbright commission (French American scholar exchange commission)
2011 - PresentPeer Review Groups and Grant Study SectionsMember
Honors
honor Award from association Laurette Fugain
07/01/2012International AwardSociété Française d’hématologieDetailsFrancehonor Award from French transfusion medicine society
07/01/2011International Awardassociation recherche transfusion/ société Française de Transfusion SanguineDetailsFrance