Heather G Allore, PhD

Professor; Director, Yale Program on Aging Biostatistics Core ; Director, Data Management and Statistics Core, Yale Alzheimer's Disease Research Center; Co-director of the Biostatistics and Bioinformatics Core of the Yale Transdisciplinary Collaborative Center for Precision Medicine focused on Health Disparities; Adjunct Professor, Harldsplass Deaconess Hospital, University of Bergen, Norway

Departments & Organizations

Internal Medicine: Geriatrics: Claude D. Pepper Older Americans Independence Center

School of Public Health: Biostatistics

Alzheimer's Disease Research Center (ADRC)

Center for Neuroepidemiology and Clinical Neurological Research

Faculty Research

Biography

The focus of my research collaborations and methodological development work as Director of Biostatistics at the Yale Program on Aging. Innovative designs for multicomponent interventional trials and biostatistical methods are required to rigorously address the myriad of unanswered scientific questions related to geriatric health conditions. My research has focused on issues related to the design and analysis of studies of multiple chronic conditions using both clinical trials and observational studies, topics that are relevant to this application. With over 160 publications, I have served as a senior biostatistician on methods papers directly related to longitudinal methods, such as trajectories of functional disability, including the first published in New England Journal of Medicine. My applied research includes developing strategies for handling missing data that frequently occur in studies of older persons; I have compared different longitudinal imputation methods in the context of older persons where censoring due to death commonly occurs, which is a theme of the Biostatistical Core’s Development Project. In addition to my multicomponent and clustered trial design research, I have a wealth of experience conducting epidemiologic studies and is a recognized authority on longitudinal statistical methods, including extended Cox models for state transitions, generalized estimating equations, mixed effects models, latent class trajectory models, joint models and recently modified the average attributable fraction for a time-to-event outcome with time-varying medical conditions.I am the founder and leader of the field of Gerontological Biostatistics. This discipline trains biostatisticians for conducting collaborative clinical research with geriatricians and gerontologists and provides the basis for the development and extension of statistical methodology. Most recently, my group is exploring time-varying effects models that have never been used in aging research and this approach allows the effects of patient or clinical characteristics to varying over time. Dissemination of methods is through a user-friendly, web-based compendium (Gerontologic Research Algorithms and Statistical Programs or GRASP) that is facilitating an interchange of analytical strategies, programs and data structures for biostatisticians, epidemiologists, and other methodologists involved in gerontological research. These and other methodologic advances resulted in being an invited speaker at an NIH/NIA conference on Longitudinal Methods and another on Clinical Trial Design. In 2017, she co-chaired Study Design and Metrics of the NIH meeting on the 21st Century Cures Act: Inclusion Across the Lifespan. Other leadership roles I undertake include Director of the Yale Alzheimer's Disease Research Center's Data Management and Statistics Core and Co-director of the Biostatistics and Bioinformatics Core of the Yale Transdisciplinary Collaborative Center for Precision Medicine focused on Health Disparities, especially those with multiple chronic conditions. I have been a Steering Committee and Data and Measures Committee member of the AGING Initiative, which a collaboration of OAICs and the Healthcare Systems Research Network.  A defining hallmark of my biostatistical approach is that instead of developing analytic methods in the absence of a clinical question or adapting the study question to available analytical techniques, she adapts new statistical methods that suitably model the specific study question.

Education & Training

PhD Cornell University (1996)
Postdoctoral Fellow Cornell University

Honors & Recognition

  • FellowGerontological Society of America (2016)

  • Women’s Midcareer Leadership Competitive ApplicationAmerican Association of Medical Colleges (2014)

  • Paul Harris Fellow Rotary International (2012)

  • NRI Competitive Grants Postdoctoral Fellowship 96-35204-3441NRI Competitive Grants Postdoctoral Fellowship (1996)

  • Gamma Sigma Delta Research AwardGamma Sigma Delta, Honor Society (1991)

  • HR Anslie Leadership AwardCornell University (1990)

Professional Service

  • NIH (2015 - Present) Special Emphasis Panel Reviewer, Support of Competitive Research (SCORE)

  • Gerontological Society of America (2014 - 2017) Health Sciences Membership Committee

  • NIH/NIA (2014 - Present) PPG P01Alzheimer’s Disease

  • Data Safety Monitoring Board (2014 - Present) Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES) Study

  • NIH/NIA (2014 - Present) Clinical Trial Advisory Panel

  • HMO Research Network/OAIC Aging Initiative (2014 - Present) Data and Measures Workgroup

  • NIH/NIA (2013) SEP Review U19 DOMINANTLY INHERITED ALZHEIMER NETWORK

  • NIH/NIAID (2011 - 2012) SEP Reviewer, P01 Immunology, NIH/NIAID

  • NIH/NIAID (2011 - 2012) SEP Immunology,

  • Partnership for Anemia: Clinical and Translational Trials (2010 - Present) Data Safety Monitoring Board

  • Yale Center for Analytic Science (2010 - Present) Yale Center for Analytic Science Executive Steering Committee

  • NIMH (2009 - 2010) Member, Special Emphasis Panel, Treatment of Mental Illness

  • Foundation for NIH review panel on Sarcopenia (2009) Review panel on Sarcopenia

  • Gerontological Society of America (2008 - Present) Convener Gerontological Society of America Measures Statistics Research Design Section

  • CDC (2008 - Present) Chair: CDC Special Emphasis Panel: Preparing People with Arthritis to Safely Select and Self Direct their Physical Activity

  • CDC (2007) CDC Mentored Public Health Research Scientist Development Award

  • NIH/NIA (2006 - 2012) NIH/NIA ASG Study Section

  • Human Nutrition and Obesity Section USDA-NRICGP (2006 - Present) Human Nutrition and Obesity Section USDA-NRICGP

  • USDA Small Business Initiative Grant Program (2003 - 2005) USDA Small Business Initiative Grant Program

  • VA Cooperative Studies Program Coordinating Center (2002 - Present) VA Cooperative Studies Program Coordinating Center Human Rights Committee

Activities

  • Sabbatical Sydney, Australia; Bergen, Norway (2016 - 2017)

  • Vice President Guilford, United States (2009 - 2014)

    Guilford Land Conservation Trust

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Contact Info

Heather G Allore, PhD
Office Location
Program on Aging300 George Street, Ste 775
New Haven, CT 06511
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Mailing Address
300 George St Suite 775
New Haven, CT 06511

Curriculum Vitae