George Hung, MD, AB
Clinical Fellow
Research & Publications
Biography
News
Selected Publications
- Paracrine-mediated rejuvenation of aged mesenchymal stem cells is associated with downregulation of the autophagy-lysosomal pathway.Hung G, Ashvetiya T, Leszczynska A, Yang W, Hwang CW, Gerstenblith G, Barth AS, Johnston PV. Paracrine-mediated rejuvenation of aged mesenchymal stem cells is associated with downregulation of the autophagy-lysosomal pathway. Npj Aging 2022, 8: 10. PMID: 35927427, PMCID: PMC9293998, DOI: 10.1038/s41514-022-00091-0.
- Digital Health Interventions for Cardiac Rehabilitation: Systematic Literature Review.Wongvibulsin S, Habeos EE, Huynh PP, Xun H, Shan R, Porosnicu Rodriguez KA, Wang J, Gandapur YK, Osuji N, Shah LM, Spaulding EM, Hung G, Knowles K, Yang WE, Marvel FA, Levin E, Maron DJ, Gordon NF, Martin SS. Digital Health Interventions for Cardiac Rehabilitation: Systematic Literature Review. Journal Of Medical Internet Research 2021, 23: e18773. PMID: 33555259, PMCID: PMC7899799, DOI: 10.2196/18773.
- Mobile health application platform 'Corrie' personalises and empowers the heart attack recovery patient experience in the hospital and at home for an underserved heart attack survivor.Hung G, Yang WE, Marvel FA, Martin SS. Mobile health application platform 'Corrie' personalises and empowers the heart attack recovery patient experience in the hospital and at home for an underserved heart attack survivor. BMJ Case Reports 2020, 13 PMID: 32071124, PMCID: PMC7046423, DOI: 10.1136/bcr-2019-231801.
- Strategies for the Successful Implementation of a Novel iPhone Loaner System (iShare) in mHealth Interventions: Prospective Study.Yang WE, Spaulding EM, Lumelsky D, Hung G, Huynh PP, Knowles K, Marvel FA, Vilarino V, Wang J, Shah LM, Xun H, Shan R, Wongvibulsin S, Martin SS. Strategies for the Successful Implementation of a Novel iPhone Loaner System (iShare) in mHealth Interventions: Prospective Study. JMIR MHealth And UHealth 2019, 7: e16391. PMID: 31841115, PMCID: PMC6937543, DOI: 10.2196/16391.
- Progress in Understanding, Diagnosing, and Managing Cardiac Complications of Systemic Sclerosis.Hung G, Mercurio V, Hsu S, Mathai SC, Shah AA, Mukherjee M. Progress in Understanding, Diagnosing, and Managing Cardiac Complications of Systemic Sclerosis. Current Rheumatology Reports 2019, 21: 68. PMID: 31813082, DOI: 10.1007/s11926-019-0867-0.
- Sustained release of endothelial progenitor cell-derived extracellular vesicles from shear-thinning hydrogels improves angiogenesis and promotes function after myocardial infarction.Chen CW, Wang LL, Zaman S, Gordon J, Arisi MF, Venkataraman CM, Chung JJ, Hung G, Gaffey AC, Spruce LA, Fazelinia H, Gorman RC, Seeholzer SH, Burdick JA, Atluri P. Sustained release of endothelial progenitor cell-derived extracellular vesicles from shear-thinning hydrogels improves angiogenesis and promotes function after myocardial infarction. Cardiovascular Research 2018, 114: 1029-1040. PMID: 29566124, PMCID: PMC5967544, DOI: 10.1093/cvr/cvy067.
- Normal human cell proteins that interact with the adenovirus type 5 E1B 55kDa protein.Hung G, Flint SJ. Normal human cell proteins that interact with the adenovirus type 5 E1B 55kDa protein. Virology 2017, 504: 12-24. PMID: 28135605, PMCID: PMC5337154, DOI: 10.1016/j.virol.2017.01.013.
- HeartMate II Left Ventricular Assist Device Geometry on Chest Radiograph Does Not Correlate with Risk of Pump Thrombosis.Han JJ, Gaffey AC, Sooppan R, Hung G, Venkataraman C, Phillips E, Howard J, McLean R, Acker MA, Atluri P. HeartMate II Left Ventricular Assist Device Geometry on Chest Radiograph Does Not Correlate with Risk of Pump Thrombosis. ASAIO Journal (American Society For Artificial Internal Organs : 1992) 2016, 62: 128-32. PMID: 26720737, DOI: 10.1097/MAT.0000000000000326.
- HBV polymerase overexpression due to large core gene deletion enhances hepatoma cell growth by binding inhibition of microRNA-100.Huang YH, Tseng YH, Lin WR, Hung G, Chen TC, Wang TH, Lee WC, Yeh CT. HBV polymerase overexpression due to large core gene deletion enhances hepatoma cell growth by binding inhibition of microRNA-100. Oncotarget 2016, 7: 9448-61. PMID: 26824500, PMCID: PMC4891051, DOI: 10.18632/oncotarget.7021.
- Minimally invasive mitral valve surgery is associated with equivalent cost and shorter hospital stay when compared with traditional sternotomy.Atluri P, Stetson RL, Hung G, Gaffey AC, Szeto WY, Acker MA, Hargrove WC. Minimally invasive mitral valve surgery is associated with equivalent cost and shorter hospital stay when compared with traditional sternotomy. The Journal Of Thoracic And Cardiovascular Surgery 2016, 151: 385-8. PMID: 26432722, DOI: 10.1016/j.jtcvs.2015.08.106.
- In Vivo Anastomosis and Perfusion of a Three-Dimensionally-Printed Construct Containing Microchannel Networks.Sooppan R, Paulsen SJ, Han J, Ta AH, Dinh P, Gaffey AC, Venkataraman C, Trubelja A, Hung G, Miller JS, Atluri P. In Vivo Anastomosis and Perfusion of a Three-Dimensionally-Printed Construct Containing Microchannel Networks. Tissue Engineering. Part C, Methods 2016, 22: 1-7. PMID: 26414863, PMCID: PMC4722541, DOI: 10.1089/ten.TEC.2015.0239.
- Injectable shear-thinning hydrogels used to deliver endothelial progenitor cells, enhance cell engraftment, and improve ischemic myocardium.Gaffey AC, Chen MH, Venkataraman CM, Trubelja A, Rodell CB, Dinh PV, Hung G, MacArthur JW, Soopan RV, Burdick JA, Atluri P. Injectable shear-thinning hydrogels used to deliver endothelial progenitor cells, enhance cell engraftment, and improve ischemic myocardium. The Journal Of Thoracic And Cardiovascular Surgery 2015, 150: 1268-76. PMID: 26293548, PMCID: PMC4637242, DOI: 10.1016/j.jtcvs.2015.07.035.
- A Tissue-Engineered Chondrocyte Cell Sheet Induces Extracellular Matrix Modification to Enhance Ventricular Biomechanics and Attenuate Myocardial Stiffness in Ischemic Cardiomyopathy.Shudo Y, Cohen JE, MacArthur JW, Goldstone AB, Otsuru S, Trubelja A, Patel J, Edwards BB, Hung G, Fairman AS, Brusalis C, Hiesinger W, Atluri P, Hiraoka A, Miyagawa S, Sawa Y, Woo YJ. A Tissue-Engineered Chondrocyte Cell Sheet Induces Extracellular Matrix Modification to Enhance Ventricular Biomechanics and Attenuate Myocardial Stiffness in Ischemic Cardiomyopathy. Tissue Engineering. Part A 2015, 21: 2515-25. PMID: 26154752, PMCID: PMC4605354, DOI: 10.1089/ten.TEA.2014.0155.
- Prior Sternotomy and Ventricular Assist Device Implantation Do Not Adversely Impact Survival or Allograft Function After Heart Transplantation.Gaffey AC, Phillips EC, Howard J, Hung G, Han J, Emery R, Goldberg L, Acker MA, Woo YJ, Atluri P. Prior Sternotomy and Ventricular Assist Device Implantation Do Not Adversely Impact Survival or Allograft Function After Heart Transplantation. The Annals Of Thoracic Surgery 2015, 100: 542-9. PMID: 26070597, DOI: 10.1016/j.athoracsur.2015.02.093.
- Preclinical Models for Translational Investigations of Left Ventricular Assist Device-Associated von Willebrand Factor Degradation.Restle DJ, Zhang DM, Hung G, Howard JL, Kallel F, Acker MA, Atluri P, Bartoli CR. Preclinical Models for Translational Investigations of Left Ventricular Assist Device-Associated von Willebrand Factor Degradation. Artificial Organs 2015, 39: 569-75. PMID: 25810063, DOI: 10.1111/aor.12428.
- Tissue-engineered, hydrogel-based endothelial progenitor cell therapy robustly revascularizes ischemic myocardium and preserves ventricular function.Atluri P, Miller JS, Emery RJ, Hung G, Trubelja A, Cohen JE, Lloyd K, Han J, Gaffey AC, MacArthur JW, Chen CS, Woo YJ. Tissue-engineered, hydrogel-based endothelial progenitor cell therapy robustly revascularizes ischemic myocardium and preserves ventricular function. The Journal Of Thoracic And Cardiovascular Surgery 2014, 148: 1090-7; discussion 1097-8. PMID: 25129603, PMCID: PMC4155940, DOI: 10.1016/j.jtcvs.2014.06.038.
- Bioengineered stromal cell-derived factor-1α analogue delivered as an angiogenic therapy significantly restores viscoelastic material properties of infarcted cardiac muscle.Trubelja A, MacArthur JW, Sarver JJ, Cohen JE, Hung G, Shudo Y, Fairman AS, Patel J, Edwards BB, Damrauer SM, Hiesinger W, Atluri P, Woo YJ. Bioengineered stromal cell-derived factor-1α analogue delivered as an angiogenic therapy significantly restores viscoelastic material properties of infarcted cardiac muscle. Journal Of Biomechanical Engineering 2014, 136 PMID: 24860865, PMCID: PMC4307777, DOI: 10.1115/1.4027731.
- A bioengineered hydrogel system enables targeted and sustained intramyocardial delivery of neuregulin, activating the cardiomyocyte cell cycle and enhancing ventricular function in a murine model of ischemic cardiomyopathy.Cohen JE, Purcell BP, MacArthur JW, Mu A, Shudo Y, Patel JB, Brusalis CM, Trubelja A, Fairman AS, Edwards BB, Davis MS, Hung G, Hiesinger W, Atluri P, Margulies KB, Burdick JA, Woo YJ. A bioengineered hydrogel system enables targeted and sustained intramyocardial delivery of neuregulin, activating the cardiomyocyte cell cycle and enhancing ventricular function in a murine model of ischemic cardiomyopathy. Circulation. Heart Failure 2014, 7: 619-26. PMID: 24902740, PMCID: PMC4157671, DOI: 10.1161/CIRCHEARTFAILURE.113.001273.
- Preclinical evaluation of the engineered stem cell chemokine stromal cell-derived factor 1α analog in a translational ovine myocardial infarction model.Macarthur JW, Cohen JE, McGarvey JR, Shudo Y, Patel JB, Trubelja A, Fairman AS, Edwards BB, Hung G, Hiesinger W, Goldstone AB, Atluri P, Wilensky RL, Pilla JJ, Gorman JH, Gorman RC, Woo YJ. Preclinical evaluation of the engineered stem cell chemokine stromal cell-derived factor 1α analog in a translational ovine myocardial infarction model. Circulation Research 2014, 114: 650-9. PMID: 24366171, PMCID: PMC4137973, DOI: 10.1161/CIRCRESAHA.114.302884.