Daniel O'Neil, MD, MPH
he/him/his
Assistant Professor; Affiliated Faculty, Yale Institute for Global Health; Clinical Member, Yale Cancer Center
Research & Publications
Biography
News
Extensive Research Description
Dr. O’Neil is a global oncology breast cancer researcher. He is particularly interested in understanding the quality of breast cancer care delivered in low- and middle-income countries. To demonstrate the feasibility of quality monitoring in resource-constrained settings, he has adapted quality metrics from the United States and Europe to describe care in Rwanda and South Africa. That work has addressed receipt of standard of care cancer treatments, treatment delays, and patient adherence to chronic anti-cancer medicines. He is currently studying techniques for improving early detection of breast cancer in South Africa, where access to mammography is limited.
He also studies the impact of comorbid HIV on breast cancer outcomes. Women living with both HIV and breast cancer consistently demonstrate higher overall mortality than women living with only breast cancer. Dr. O'Neil's comparisons of breast cancer treatment quality in South African women with and without comorbid HIV have shown that this disparity in mortality is not primarily driven by differences in cancer care. He is currently working with collaborators in Johannesburg and New Haven, looking for differences in tumor behavior or anti-tumor immune response in women living with HIV.
Research Interests
Quality of Health Care; Global Health
Public Health Interests
Cancer; Global Health
Selected Publications
- The impact of HIV on non-adherence for tamoxifen among women with breast cancer in South Africa.Ayeni OA, Chiwambutsa S, Chen WC, Kapungu N, Kanji C, Thelingwani R, Murugan N, Mathiba R, Phakathi B, Nietz S, Ramiah D, O'Neil DS, Jacobson JS, Ruff P, Cubasch H, Chirwa T, Joffe M, Masimirembwa C, Neugut AI. The impact of HIV on non-adherence for tamoxifen among women with breast cancer in South Africa. Breast Cancer Res Treat 2022 PMID: 36538247, DOI: 10.1007/s10549-022-06835-6.
- Impact of HIV infection on survival among women with stage I-III breast cancer: Results from the South African breast cancer and HIV outcomes study.Ayeni OA, O'Neil DS, Pumpalova YS, Chen WC, Nietz S, Phakathi B, Buccimazza I, Čačala S, Stopforth LW, Farrow HA, Mapanga W, Joffe M, Chirwa T, McCormack V, Jacobson JS, Crew KD, Neugut AI, Ruff P, Cubasch H. Impact of HIV infection on survival among women with stage I-III breast cancer: Results from the South African breast cancer and HIV outcomes study. Int J Cancer 2022, 151: 209-221. PMID: 35218568, DOI: 10.1002/ijc.33981.
- The Impact of Breast Cancer Treatment Delays on Survival Among South African Women.Pumpalova YS, Ayeni OA, Chen WC, Buccimazza I, Cačala S, Stopforth LW, Farrow HA, Mapanga W, Nietz S, Phakathi B, Joffe M, McCormack V, Jacobson JS, Crew KD, Neugut AI, Ruff P, Cubasch H, O'Neil DS. The Impact of Breast Cancer Treatment Delays on Survival Among South African Women. Oncologist 2022, 27: e233-e243. PMID: 35274708, DOI: 10.1093/oncolo/oyab054.
- Validating an Instrument for Direct Patient Reporting of Distress and Chemotherapy-Related Toxicity among South African Cancer Patients.Blanchard CL, Mmoledi K, Antoni MH, Demetriou G, Joffe M, Lopes G, Ruff P, O'Neil DS. Validating an Instrument for Direct Patient Reporting of Distress and Chemotherapy-Related Toxicity among South African Cancer Patients. Cancers (Basel) 2021, 14 PMID: 35008258, DOI: 10.3390/cancers14010095.
- Breast Cancer Early Detection in Eswatini: Evaluation of a Training Curriculum and Patient Receipt of Recommended Follow-Up Care.O'Neil DS, Nxumalo S, Ngcamphalala C, Tharp G, Jacobson JS, Nuwagaba-Biribonwoha H, Dlamini X, Pace LE, Neugut AI, Harris TG. Breast Cancer Early Detection in Eswatini: Evaluation of a Training Curriculum and Patient Receipt of Recommended Follow-Up Care. JCO Glob Oncol 2021, 7: 1349-1357. PMID: 34491814, DOI: 10.1200/GO.21.00124.
- Impact of HIV infection on overall survival among women with stage IV breast cancer in South Africa.Pumpalova YS, Ayeni OA, Chen WC, O'Neil DS, Nietz S, Phakathi B, Buccimazza I, Čačala S, Stopforth LW, Farrow HA, Joffe M, Mapanga W, Jacobson JS, Crew KD, Cubasch H, Ruff P, Neugut AI. Impact of HIV infection on overall survival among women with stage IV breast cancer in South Africa. Breast Cancer Res Treat 2021, 189: 285-296. PMID: 34125339, DOI: 10.1007/s10549-021-06265-w.
- Quality of Histopathological Reporting in Breast Cancer: Results From Four South African Breast Units.Toma A, O'Neil D, Joffe M, Ayeni O, Nel C, van den Berg E, Nayler S, Cubasch H, Phakathi B, Buccimazza I, Čačala S, Ruff P, Norris S, Nietz S. Quality of Histopathological Reporting in Breast Cancer: Results From Four South African Breast Units. JCO Glob Oncol 2021, 7: 72-80. PMID: 33434068, DOI: 10.1200/GO.20.00402.
- Identifying Breast Cancer Care Quality Measures for a Cancer Facility in Rural Sub-Saharan Africa: Results of a Systematic Literature Review and Modified Delphi Process.Pace LE, Schleimer LE, Shyirambere C, Ilbawi A, Dusengimana JMV, Bigirimana JB, Uwizeye FR, Chamberlin M, Lee YS, Shulman LN, Troyan S, Anderson BO, Duggan C, O'Neil DS, Dvaladze A, Brock J, Nguyen C, Ruhangaza D, Habimana O, Nsabimana N, Butonzi J, Nkusi E, Mpunga T, Keating NL. Identifying Breast Cancer Care Quality Measures for a Cancer Facility in Rural Sub-Saharan Africa: Results of a Systematic Literature Review and Modified Delphi Process. JCO Glob Oncol 2020, 6: 1446-1454. PMID: 32997538, DOI: 10.1200/GO.20.00186.
- A comparison of complete pathologic response rates following neoadjuvant chemotherapy among South African breast cancer patients with and without concurrent HIV infection.Nietz S, O'Neil DS, Ayeni O, Chen WC, Joffe M, Jacobson JS, Neugut AI, Ruff P, Mapanga W, Buccimazza I, Singh U, Čačala S, Stopforth L, Phakathi B, Chirwa T, Cubasch H. A comparison of complete pathologic response rates following neoadjuvant chemotherapy among South African breast cancer patients with and without concurrent HIV infection. Breast Cancer Res Treat 2020, 184: 861-872. PMID: 32875480, DOI: 10.1007/s10549-020-05889-8.
- Breast Cancer Care Quality in South Africa's Public Health System: An Evaluation Using American Society of Clinical Oncology/National Quality Forum Measures.O'Neil DS, Chen WC, Ayeni O, Nietz S, Buccimazza I, Singh U, Čačala S, Stopforth L, Joffe M, Crew KD, Jacobson JS, Neugut AI, Ruff P, Cubasch H. Breast Cancer Care Quality in South Africa's Public Health System: An Evaluation Using American Society of Clinical Oncology/National Quality Forum Measures. J Glob Oncol 2019, 5: 1-16. PMID: 31770052, DOI: 10.1200/JGO.19.00171.
- Quality of Breast Cancer Treatment at a Rural Cancer Center in Rwanda.O'Neil DS, Keating NL, Dusengimana JMV, Hategekimana V, Umwizera A, Mpunga T, Shulman LN, Pace LE. Quality of Breast Cancer Treatment at a Rural Cancer Center in Rwanda. J Glob Oncol 2018, 4: 1-11. PMID: 30241207, DOI: 10.1200/JGO.2016.008672.
- Evaluation of care access and hypertension control in a community health worker driven non-communicable disease programme in rural Uganda: the chronic disease in the community project.O'Neil DS, Lam WC, Nyirangirimana P, Burton WB, Baganizi M, Musominali S, Bareke D, Paccione GA. Evaluation of care access and hypertension control in a community health worker driven non-communicable disease programme in rural Uganda: the chronic disease in the community project. Health Policy Plan 2016, 31: 878-883. PMID: 26962122, DOI: 10.1093/heapol/czw006.