Michael Rehman, PhD
Associate Research ScientistCards
About
Research
Publications
2025
Novel Endogenous Pkd1 Reexpression Allele and Effects of Mosaic Reexpression of Pkd1 in ADPKD
Cordido A, Dong K, Cai Y, Tian X, Wei Z, Rehman M, Roy K, Somlo S. Novel Endogenous Pkd1 Reexpression Allele and Effects of Mosaic Reexpression of Pkd1 in ADPKD. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025kkmvzqz1. DOI: 10.1681/asn.2025kkmvzqz1.Peer-Reviewed Original ResearchAnks3 Mediates Cilia-Dependent Polycystin Signaling and Is Essential for Adult Kidney Homeostasis
Wei Z, Rehman M, Dong K, Roy K, Cordido A, Cai Y, Tian X, Somlo S. Anks3 Mediates Cilia-Dependent Polycystin Signaling and Is Essential for Adult Kidney Homeostasis. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025jd14p7gt. DOI: 10.1681/asn.2025jd14p7gt.Peer-Reviewed Original ResearchTherapeutic Targeting of Ire1alpha Endoribonuclease Domain Ameliorates ADPKD in Orthologous Mouse Models
Bhardwaj R, Hasan F, Volpe I, Yilmaz D, Pioppini C, Rehman M, Cai Y, Somlo S, Krappitz M, Fedeles S. Therapeutic Targeting of Ire1alpha Endoribonuclease Domain Ameliorates ADPKD in Orthologous Mouse Models. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.20250zac2xtx. DOI: 10.1681/asn.20250zac2xtx.Peer-Reviewed Original Research
2024
Glis3 Is a Modifier of Cyst Progression in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Wei Z, Tian X, Rehman M, Dong K, Cai Y, Cordido A, Somlo S. Glis3 Is a Modifier of Cyst Progression in Autosomal Dominant Polycystic Kidney Disease (ADPKD). Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024x2zerq4t. DOI: 10.1681/asn.2024x2zerq4t.Peer-Reviewed Original ResearchFunctional Studies of Polycystin-1 Using a Novel Pkd1-HaloTag Mouse
Cordido A, Dong K, Cai Y, Tian X, Wei Z, Rehman M, Somlo S. Functional Studies of Polycystin-1 Using a Novel Pkd1-HaloTag Mouse. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024kjqymtyt. DOI: 10.1681/asn.2024kjqymtyt.Peer-Reviewed Original ResearchChemical Modulation of the Ire1α-Xbp1 Pathway Reduces Cyst Size in ADPKD Mouse and Human Three-Dimensional Spheroids
Hasan F, Bhardwaj R, Rehman M, Cai Y, Dong K, Cordido A, Pioppini C, Yilmaz D, Tian X, Somlo S, Krappitz M, Fedeles S. Chemical Modulation of the Ire1α-Xbp1 Pathway Reduces Cyst Size in ADPKD Mouse and Human Three-Dimensional Spheroids. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024x8qpvhm3. DOI: 10.1681/asn.2024x8qpvhm3.Peer-Reviewed Original ResearchGlis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease
Zhang C, Rehman M, Tian X, Pei S, Gu J, Bell T, Dong K, Tham M, Cai Y, Wei Z, Behrens F, Jetten A, Zhao H, Lek M, Somlo S. Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease. Nature Communications 2024, 15: 3698. PMID: 38693102, PMCID: PMC11063051, DOI: 10.1038/s41467-024-48025-6.Peer-Reviewed Original ResearchConceptsMouse models of autosomal dominant polycystic kidney diseaseModel of autosomal dominant polycystic kidney diseasePolycystin signalingAutosomal dominant polycystic kidney diseasePolycystin-1Polycystic kidney diseaseTreat autosomal dominant polycystic kidney diseaseGlis2Primary ciliaKidney tubule cellsSignaling pathwayMouse modelDominant polycystic kidney diseasePotential therapeutic targetTranslatomeAntisense oligonucleotidesKidney diseasePolycystinMouse kidneyFunctional effectorsCyst formationTherapeutic targetInactivationFunctional targetPharmacological targetsA synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress
Fedeles B, Bhardwaj R, Ishikawa Y, Khumsubdee S, Krappitz M, Gubina N, Volpe I, Andrade D, Westergerling P, Staudner T, Campolo J, Liu S, Dong K, Cai Y, Rehman M, Gallagher A, Ruchirawat S, Croy R, Essigmann J, Fedeles S, Somlo S. A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2317344121. PMID: 38241440, PMCID: PMC10823221, DOI: 10.1073/pnas.2317344121.Peer-Reviewed Original ResearchConceptsCyst cellsAutosomal dominant polycystic kidney diseaseMouse models of autosomal dominant polycystic kidney diseasePolycystic kidney diseaseModel of autosomal dominant polycystic kidney diseaseKidney diseaseDeveloped primersMitochondrial oxidative stressPathophysiology of autosomal dominant polycystic kidney diseaseOxidative stressInduce apoptosisMitochondrial respirationCystic cellsUp-regulating aerobic glycolysisHomozygous inactivationMonogenic causeDominant polycystic kidney diseaseAerobic glycolysisRenal replacement therapyApoptosisEnd-stage kidney diseaseAnti-tumor agentsAdult mouse modelChronic kidney diseaseAlkylate DNA
2023
Inactivation of Ire1alpha Endoribonuclease Domain Slows Down ADPKD in Orthologous Mouse Models
Bhardwaj R, Volpe I, Yilmaz D, Pioppini C, Roy K, Rehman M, Cai Y, Krappitz M, Somlo S, Fedeles S. Inactivation of Ire1alpha Endoribonuclease Domain Slows Down ADPKD in Orthologous Mouse Models. Journal Of The American Society Of Nephrology 2023, 34: 19-19. DOI: 10.1681/asn.20233411s119b.Peer-Reviewed Original Research
2022
Pkd2 Re-Expression Can Reverse Liver Cysts and Improve GFR in Mouse Models of Autosomal Dominant Polycystic Kidney Disease
Dong K, Tham M, Cordido A, Cai Y, Pei S, Bhardwaj R, Wei Z, Rehman M, Roy K, Tian X, Somlo S. Pkd2 Re-Expression Can Reverse Liver Cysts and Improve GFR in Mouse Models of Autosomal Dominant Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2022, 33: 418-418. DOI: 10.1681/asn.20223311s1418c.Peer-Reviewed Original Research