Genta Ishikawa, MD, MPH
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Biography
Built on a strong foundation of academic training as a pulmonologist in Japan and the United States, Dr. Ishikawa has an enduring passion for pioneering innovative treatments for pulmonary fibrosis. After completing his clinical training in Japan, Dr. Ishikawa sought to broaden his medical expertise in the United States. He honed his research skills and expanded his knowledge base by earning a Master of Public Health (MPH) degree from Emory University.
Driven by his relentless pursuit of excellence, Dr. Ishikawa further bolstered his credentials by undertaking an Internal Medicine Residency and a Fellowship in Pulmonary Critical Care and Sleep Medicine at Mount Sinai, New York. During this comprehensive clinical training, he faced the harsh realities of pulmonary fibrosis — a relentless, fatal form of progressive interstitial lung disease (ILD). This impactful experience galvanized Dr. Ishikawa to dedicate his career to devising innovative treatments for this severe condition.
Committed to advancing his mission, Dr. Ishikawa embarked on a postdoctoral fellowship at Yale University under the expert guidance of the esteemed Dr. Erica L. Herzog. As part of his role, he also has the privilege of caring for ILD patients at the Yale Center for Interstitial Lung Diseases, an experience that lends practical insights to his research work.
Currently, within the intellectually stimulating environment of Dr. Herzog's laboratory, Dr. Ishikawa is investigating a recently discovered neuro-innate fibrotic mechanism. This intriguing mechanism entails complex interactions between nerve-derived noradrenaline and lung macrophages that express alpha-1 adrenoreceptors.
Guided by a vision to transform the treatment landscape for pulmonary fibrosis, Dr. Ishikawa's ultimate goal is to translate these intricate scientific findings into potent, effective therapies. He remains staunchly dedicated to this pursuit, propelled by the hope that his research will contribute significantly to advancing patient care.
Appointments
Pulmonary, Critical Care & Sleep Medicine
InstructorPrimary
Other Departments & Organizations
- Internal Medicine
- Janeway Society
- Pulmonary, Critical Care & Sleep Medicine
- Yale Medicine
Education & Training
- Postdoctoral Fellow
- Yale University (2023)
- Clinical Fellow
- Mount Sinai Hospital (2020)
- Resident
- Mount Sinai Beth Israel (2017)
- MPH
- Emory University, Rollins School of Public Health (2017)
- Intern
- Mount Sinai Beth Israel (2015)
- Clinical Fellow
- St. Luke's International Hospital (2013)
- Resident
- Juntendo University Hospital (2009)
- MD
- Hokkaido University, School of Medicine (2007)
Research
Publications
2024
Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis.
Unterman A, Zhao A, Neumark N, Schupp J, Ahangari F, Cosme C, Sharma P, Flint J, Stein Y, Ryu C, Ishikawa G, Sumida T, Gomez J, Herazo-Maya J, Dela Cruz C, Herzog E, Kaminski N. Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2024 PMID: 38717443, DOI: 10.1164/rccm.202306-0979oc.Peer-Reviewed Original ResearchStable idiopathic pulmonary fibrosisIdiopathic pulmonary fibrosisPeripheral blood mononuclear cellsProgressive idiopathic pulmonary fibrosisPeripheral immune systemT cellsPulmonary fibrosisCohort of IPF patientsAssociated with decreased survivalIdiopathic pulmonary fibrosis patientsPeripheral blood mononuclear cell samplesPeripheral blood cell populationsImmune systemFraction of TregsRegulatory T cellsBlood mononuclear cellsBlood cell populationsFlow cytometry analysisImmune aberrationsIPF patientsTregsMononuclear cellsSingle-cell RNA sequencingLung homogenatesMonocyte chemoattractantRole of Noradrenaline and Macrophage Dynamics in Pulmonary Fibrosis
Ishikawa G, Peng X, Mcgovern J, Ghincea A, Saber T, Sun H, Sauler M, Ryu C, Herzog E. Role of Noradrenaline and Macrophage Dynamics in Pulmonary Fibrosis. 2024, a5206-a5206. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5206.Peer-Reviewed Original Research
2023
Toll-like Receptor-9 Activation Promotes Persistent Inflammation in the Lung During Influenza Infection
Essayas H, Kim J, Mcgovern J, Peng X, Cai Y, Ishikawa G, Herzog E, Dela Cruz C, Ryu C, Sharma L. Toll-like Receptor-9 Activation Promotes Persistent Inflammation in the Lung During Influenza Infection. 2023, a5608-a5608. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a5608.Peer-Reviewed Original Researchα1 Adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with idiopathic pulmonary fibrosis
Ishikawa G, Peng X, McGovern J, Woo S, Perry C, Liu A, Yu S, Ghincea A, Kishchanka A, Fiorini V, Hu B, Sun Y, Sun H, Ryu C, Herzog E. α1 Adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with idiopathic pulmonary fibrosis. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2023, 324: l639-l651. PMID: 36648147, PMCID: PMC10110730, DOI: 10.1152/ajplung.00119.2022.Peer-Reviewed Original ResearchConceptsAdrenergic nerve supplyIdiopathic pulmonary fibrosisΑ1 adrenoreceptorsPulmonary fibrosisNerve supplyCultured normal human lung fibroblastsInnate immune ligandsLung fibrosis modelNormal human lung fibroblastsSmooth muscle actinHuman lung fibroblastsAdrenal resectionAdrenoreceptor antagonismExtracellular mtDNAIPF cohortImproved survivalΑ1-adrenoreceptor antagonistsLung fibrosisAdrenal sourceFibroblast accumulationAdrenoreceptor antagonistBleomycin modelFibrosis modelLung fibrogenesisMouse model
2022
PTX3 in Granuloma Formation and Sarcoidosis: Helping Macrophages Accept a “Complement”
Ishikawa G, Herzog EL. PTX3 in Granuloma Formation and Sarcoidosis: Helping Macrophages Accept a “Complement”. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 1064-1065. PMID: 35820078, PMCID: PMC9704837, DOI: 10.1164/rccm.202207-1277ed.Commentaries, Editorials and Letters
2021
Evolving Perspectives on Innate Immune Mechanisms of IPF
Ishikawa G, Liu A, Herzog EL. Evolving Perspectives on Innate Immune Mechanisms of IPF. Frontiers In Molecular Biosciences 2021, 8: 676569. PMID: 34434962, PMCID: PMC8381017, DOI: 10.3389/fmolb.2021.676569.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisInnate immunityInnate immune populationsMolecular patternsMyeloid suppressor cellsInnate lymphoid cellsInnate immune mechanismsEpithelial-fibroblast interactionsRole of substancesSuppressor cellsPulmonary fibrosisImmune populationsImmune mechanismsDisease outcomePotential therapyLymphoid cellsHuman studiesFibrotic microenvironmentCommensal microbesAnimal modelingGenetic factorsImmunityFuture studiesComplex roleCellsElevated IL-15 concentrations in the sarcoidosis lung are independent of granuloma burden and disease phenotypes
Minasyan M, Sharma L, Pivarnik T, Liu W, Adams T, Bermejo S, Peng X, Liu A, Ishikawa G, Perry C, Kaminski N, Gulati M, Herzog EL, Dela Cruz CS, Ryu C. Elevated IL-15 concentrations in the sarcoidosis lung are independent of granuloma burden and disease phenotypes. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2021, 320: l1137-l1146. PMID: 33851886, PMCID: PMC8285626, DOI: 10.1152/ajplung.00575.2020.Peer-Reviewed Original ResearchConceptsIL-15 concentrationsIL-15Bronchoalveolar lavageDisease pathogenesisSarcoidosis lungClinical manifestationsLineages of miceIL-15 receptor αHuman cohortsInflammation of sarcoidosisIL-15 levelsOngoing inflammatory processSystemic granulomatous diseaseNumber of granulomasDisease phenotypeSarcoidosis cohortTDM administrationGranuloma numberComorbid conditionsClinical progressionInterleukin-15Granulomatous diseaseInflammatory processGranuloma formationHealthy controlsMacrophage-derived netrin-1 drives adrenergic nerve–associated lung fibrosis
Gao R, Peng X, Perry C, Sun H, Ntokou A, Ryu C, Gomez JL, Reeves BC, Walia A, Kaminski N, Neumark N, Ishikawa G, Black KE, Hariri LP, Moore MW, Gulati M, Homer RJ, Greif DM, Eltzschig HK, Herzog EL. Macrophage-derived netrin-1 drives adrenergic nerve–associated lung fibrosis. Journal Of Clinical Investigation 2021, 131: e136542. PMID: 33393489, PMCID: PMC7773383, DOI: 10.1172/jci136542.Peer-Reviewed Original ResearchConceptsNetrin-1Lung fibrosisCell-specific knockout miceΑ1-adrenoreceptor blockadeIPF lung tissueNeuronal guidance proteinsNetrin-1 expressionExtracellular matrix accumulationAdrenergic processesAdrenoreceptor antagonismAdrenoreceptor blockadeFibrotic histologyInflammatory scarringIPF cohortAdrenergic nervesΑ1-blockersImproved survivalColorectal carcinomaLung tissueKnockout miceCollagen accumulationFibrosisMatrix accumulationMacrophagesGuidance proteins
2019
Shared and Tissue-Specific Expression Signatures between Bone Marrow from Primary Myelofibrosis and Essential Thrombocythemia
Ishikawa G, Fujiwara N, Hirschfield H, Varricchio L, Hoshida Y, Barosi G, Rosti V, Padilla M, Mazzarini M, Friedman SL, Hoffman R, Migliaccio AR. Shared and Tissue-Specific Expression Signatures between Bone Marrow from Primary Myelofibrosis and Essential Thrombocythemia. Experimental Hematology 2019, 79: 16-25.e3. PMID: 31678370, PMCID: PMC6910948, DOI: 10.1016/j.exphem.2019.10.001.Peer-Reviewed Original ResearchConceptsBone marrowLung fibrosisMyeloproliferative neoplasmsEssential thrombocytopeniaLiver fibrosisPhiladelphia-negative myeloproliferative neoplasmsProtein 1Possible therapeutic targetPrimary myelofibrosis patientsExpression of Id1Extracellular matrix protein 1Poor prognosisIL-8Myelofibrosis patientsEssential thrombocythemiaTherapeutic targetPrimary myelofibrosisFibrosisMegakaryocyte hyperplasiaCholesterol homeostasisBM functionHematopoietic failureMatrix protein 1K-rasPotential targetConcomitant Interstitial Lung Disease with Psoriasis
Ishikawa G, Dua S, Mathur A, Acquah SO, Salvatore M, Beasley MB, Padilla ML. Concomitant Interstitial Lung Disease with Psoriasis. Canadian Respiratory Journal 2019, 2019: 5919304. PMID: 31534591, PMCID: PMC6732645, DOI: 10.1155/2019/5919304.Peer-Reviewed Original ResearchConceptsNonspecific interstitial pneumoniaPneumonia patternConcomitant diagnosisConcomitant interstitial lung diseaseInterstitial lung disease patientsUsual interstitial pneumonia patternChronic hypersensitivity pneumonitisLung disease patientsCryptogenic organizing pneumoniaFurther prospective studiesIdiopathic pulmonary fibrosisInterstitial lung diseaseInterstitial pneumonia patternMount Sinai HospitalConcomitant psoriasisNSIP patternILD patientsImmunosuppressive therapyOrganizing pneumoniaInterstitial pneumoniaMedian ageRetrospective reviewCase seriesPulmonary fibrosisHypersensitivity pneumonitis
Academic Achievements and Community Involvement
Clinical Care
Overview
Clinical Specialties
Fact Sheets
Interstitial Lung Disease (ILD)
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Learn More on Yale MedicinePreparing for Dialysis (AV Fistula)
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Board Certifications
Critical Care Medicine (Internal Medicine)
- Certification Organization
- AB of Imaging Informatics
- Original Certification Date
- 2020
Pulmonary Disease
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2019
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2017
Yale Medicine News
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News
- May 12, 2021
Discoveries & Impact (May 2021)
- February 10, 2021
Discoveries & Impact (February 2021)