Abigail Demuyakor, MD, PhD
Associate Research ScientistCards
About
Research
Publications
2023
Pancoronary plaque characteristics and clinical outcomes in acute coronary syndrome patients with cancer history
Wang C, Tian X, Feng X, Demuyakor A, Hu S, Wang Y, Li L, Cui L, Dong F, Dai J, Lei F, Xu Y, Du Z, Shi M, Liu J, Xing L, E M. Pancoronary plaque characteristics and clinical outcomes in acute coronary syndrome patients with cancer history. Atherosclerosis 2023, 378: 117118. PMID: 37127496, DOI: 10.1016/j.atherosclerosis.2023.03.023.Peer-Reviewed Original ResearchConceptsAcute coronary syndrome patientsAcute coronary syndromeMaximum lipid arcOptical coherence tomographyThin-cap fibroatheromaCancer historyFibrous cap thicknessPercutaneous coronary interventionNonculprit lesionsLipid arcPrevalence of high-risk plaqueIncidence of thin-cap fibroatheromaCulprit lesionPrevalence of acute coronary syndromeHigh-risk plaque featuresHigher incidencePlaque characteristicsTime of percutaneous coronary interventionAssociated with high mortalityCharacteristics of coronary plaquesLipid indicesAbsence of cancer historyCoronary syndrome patientsNon-culprit lesionsIncidence of calcification
2022
Clinical Characteristics and Prognosis of MINOCA Caused by Atherosclerotic and Nonatherosclerotic Mechanisms Assessed by OCT
Zeng M, Zhao C, Bao X, Liu M, He L, Xu Y, Meng W, Qin Y, Weng Z, Yi B, Zhang D, Wang S, Luo X, Lv Y, Chen X, Sun Q, Feng X, Gao Z, Sun Y, Demuyakor A, Li J, Hu S, Guagliumi G, Mintz G, Jia H, Yu B. Clinical Characteristics and Prognosis of MINOCA Caused by Atherosclerotic and Nonatherosclerotic Mechanisms Assessed by OCT. JACC Cardiovascular Imaging 2022, 16: 521-532. PMID: 36648054, DOI: 10.1016/j.jcmg.2022.10.023.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsOptical coherence tomographyTarget lesion revascularizationCardiac deathLesion revascularizationPredictors of Major Adverse Cardiac EventsAssociated with worse outcomesSpontaneous coronary artery dissectionClinical diagnosis of MIPrognosis of MINOCAMechanisms of MINOCAAdverse cardiac eventsNonobstructive coronary arteriesPrognosis of patientsCoronary artery dissectionDiagnosis of MIOCT findingsAtherosclerotic causeCardiac eventsClinical characteristicsClinical outcomesArtery dissectionComposite endpointMINOCACoronary spasmImpact of nodular calcification in patients with acute coronary syndrome (ACS) treated with primary percutaneous coronary intervention (PCI)
Demuyakor A, Hu S, Koniaeva E, Liu M, Weng Z, Zhao C, Feng X, He L, Xu Y, Zeng M, Meng W, Sun Y, Yi B, Gao Z, Qin Y, Jia H, Mintz G, Yu B. Impact of nodular calcification in patients with acute coronary syndrome (ACS) treated with primary percutaneous coronary intervention (PCI). BMC Cardiovascular Disorders 2022, 22: 103. PMID: 35287572, PMCID: PMC8922875, DOI: 10.1186/s12872-022-02551-7.Peer-Reviewed Original ResearchConceptsAcute coronary syndromePercutaneous coronary interventionPrimary percutaneous coronary interventionCalcification groupOptical coherence tomographyNodular calcificationStent under-expansionCoronary interventionCoronary syndromeLower left ventricular ejection fractionPresence of nodular calcificationTreated with primary percutaneous coronary interventionUnder-expansionCulprit plaquesVentricular ejection fractionMinimum stent areaEjection fractionProtruding massCoherence tomographyWell-delineated borderPatientsStent areaCalcificationImpact outcomesSignal attenuation
2021
Impact of nodular calcification on the outcomes of patients with acute coronary syndrome (ACS) treated with primary percutaneous coronary intervention (PCI)
Demuyakor A, Hu S, Koniaeva E, Liu M, Weng Z, Zhao C, Feng X, He L, Xu Y, Zeng M, Meng W, Yi B, Qin Y, Jia H, Bo Y. Impact of nodular calcification on the outcomes of patients with acute coronary syndrome (ACS) treated with primary percutaneous coronary intervention (PCI). European Heart Journal 2021, 42: ehab724.1249. DOI: 10.1093/eurheartj/ehab724.1249.Peer-Reviewed Original ResearchAcute coronary syndromePercutaneous coronary interventionPrimary percutaneous coronary interventionOutcomes of patientsCalcification groupOptical coherence tomographyNodular calcificationCoronary syndromeMinimum stent areaCoronary interventionLower left ventricular ejection fractionPresence of nodular calcificationTreated with primary percutaneous coronary interventionAssociated with unfavourable outcomeIncidence of stentsAcute coronary syndrome patientsVentricular ejection fractionLesion lengthImpact clinical outcomesEjection fractionIndependent predictorsProtruding massClinical outcomesUnfavourable outcomeResults PatientsPredictors of non-stenting strategy for acute coronary syndrome caused by plaque erosion: four-year outcomes of the EROSION study.
He L, Qin Y, Xu Y, Hu S, Wang Y, Zeng M, Feng X, Liu Q, Syed I, Demuyakor A, Zhao C, Chen X, Li Z, Meng W, Xu M, Liu H, Ma L, Dai J, Xing L, Yu H, Hou J, Jia H, Mintz G, Yu B. Predictors of non-stenting strategy for acute coronary syndrome caused by plaque erosion: four-year outcomes of the EROSION study. EuroIntervention 2021, 17: 497-505. PMID: 33164894, PMCID: PMC9724919, DOI: 10.4244/eij-d-20-00299.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeNon-TLR groupLong-term prognosisOptical coherence tomographyFollow-upAntithrombotic therapyCoronary syndromePredictor of long-term prognosisResponse to antithrombotic therapyTreated with antithrombotic therapyPlaque erosionLong-term follow-upTarget lesion revascularisationMedian durationPrimary endpointAntithrombotic strategiesOne-month follow-upThrombus reductionGastrointestinal bleedingAngiographic resultsCoherence tomographyStent implantationDiameter stenosisClinic visitsPatientsIs the effect of atorvastatin 60 mg on stabilization of lipid‐rich plaque equivalent to that of rosuvastatin 10 mg? A serial optical coherence tomography combined with intravascular ultrasound imaging
Xu M, Demuyakor A, Hu S, Liu H, Zhao C, Chen T, Qin Y, Xu Y, Feng X, Zeng M, Weng Z, Gao Z, Hou J, Jia H, Zhang S, Yu B. Is the effect of atorvastatin 60 mg on stabilization of lipid‐rich plaque equivalent to that of rosuvastatin 10 mg? A serial optical coherence tomography combined with intravascular ultrasound imaging. Catheterization And Cardiovascular Interventions 2021, 97: 1097-1107. PMID: 33864710, DOI: 10.1002/ccd.29654.Peer-Reviewed Original ResearchConceptsOptical coherence tomographyLipid-rich plaquesLipid lowering therapyEffect of atorvastatinFibrous cap thicknessStatin therapyLowering therapyCoherence tomographyIntensive lipid lowering therapySerial optical coherence tomographyCholesterol levelsLow-density lipoprotein cholesterol levelsIntravascular ultrasound imagingLipoprotein cholesterol levelsCholesterol level reductionLipid arcClinical benefitFollow-upPlaque volumeUltrasound imagingTherapyTherapy effectsPlaque burdenPercentage changeStatins
2020
Contraceptive use among women with a history of induced abortion: findings from a national sample of sexually active, non-pregnant women in Ghana
Adampah T, Angwa L, Demuyakor A, Achinkok D, Boah M. Contraceptive use among women with a history of induced abortion: findings from a national sample of sexually active, non-pregnant women in Ghana. The European Journal Of Contraception & Reproductive Health Care 2020, 25: 394-401. PMID: 32684009, DOI: 10.1080/13625187.2020.1795117.Peer-Reviewed Original ResearchConceptsHistory of induced abortionMethod of contraceptionNon-pregnant womenModern methods of contraceptionContraceptive useCurrent contraceptive usersSexually active womenSurvey logistic regression analysisReproductive-age womenExperiences of induced abortionLogistic regression analysisAssociated with modern contraceptive useStatistically significant associationContraceptive usersModern contraceptive useActive womenContraceptionSignificant associationWomenModern contraceptivesAbortionContraceptive behaviorRegression analysisHealth SurveyAnalysed data
2019
Classification of Culprit Ruptured Plaque Morphologies in Patients With STEMI: An OCT Study.
Wang C, Hu S, Feng N, Li J, Wang Y, Dong H, Sun R, Yu H, Li L, Qin Y, Feng X, Li Z, Afolabi A, Syed I, Zhang S, Guagliumi G, Jia H, Yu B. Classification of Culprit Ruptured Plaque Morphologies in Patients With STEMI: An OCT Study. JACC Cardiovasc Imaging 2019, 12: 2077-2079. PMID: 31326474, DOI: 10.1016/j.jcmg.2019.04.013.Peer-Reviewed Original Research
2018
Does spotty calcification attenuate the response of nonculprit plaque to statin therapy?: A serial optical coherence tomography study
Afolabi A, Mustafina I, Zhao L, Li L, Sun R, Hu S, Zhang S, Jia H, Guilio G, Yu B. Does spotty calcification attenuate the response of nonculprit plaque to statin therapy?: A serial optical coherence tomography study. Catheterization And Cardiovascular Interventions 2018, 91: 582-590. PMID: 29359491, DOI: 10.1002/ccd.27496.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary AngiographyCoronary Artery DiseaseCoronary VesselsFemaleFibrosisHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsRandomized Controlled Trials as TopicTime FactorsTomography, Optical CoherenceTreatment OutcomeVascular CalcificationConceptsStatin therapyOptical coherence tomographyFibrous cap thicknessSpotty calcificationIntensity statinsModerate statin therapyPresence of spotty calcificationBaseline to 6Lipid-rich plaquesModerate statinsLipid arcCalcification groupCoherence tomographyStatinsTherapyPlaque characteristicsPlaque stabilityCalcificationPlaque progressionMonthsPlaquePatientsVulnerable plaquesMarkers of vulnerable plaqueBaseline
2017
Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study
Zhu Y, Lin L, Wang C, Jia H, Hu S, Li L, Zhang X, Zheng G, Wang Y, Sun R, Afolabi A, Mustafina I, Hou J, Zhang S, Yu B. Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study. Oncotarget 2017, 5: 27401-27411. PMID: 28404965, PMCID: PMC5432344, DOI: 10.18632/oncotarget.16172.Peer-Reviewed Original ResearchConceptsImpact of statin therapyLipid-rich plaquesStatin therapyFibrous cap thicknessGroup BFramingham risk scoreGroup AOptical coherence tomography studiesRisk scoreBaseline to 6 monthsLower risk group ARisk group ABaseline characteristicsRisk group BMorphological changesTherapyOCT imagesPatientsLipid indicesTomography studiesStatinsPlaqueCHDFraminghamBaseline