Simona Jakab, MD
Associate Professor of Medicine (Digestive Diseases)Cards
About
Research
Overview
Medical Research Interests
Liver Cirrhosis; Palliative Care
Publications
2024
Gut microbiome profiles to exclude the diagnosis of hepatic encephalopathy in patients with cirrhosis
Bajaj J, O’Leary J, Jakab S, Fagan A, Sikaroodi M, Gillevet P. Gut microbiome profiles to exclude the diagnosis of hepatic encephalopathy in patients with cirrhosis. Gut Microbes 2024, 16: 2392880. PMID: 39189586, PMCID: PMC11352695, DOI: 10.1080/19490976.2024.2392880.Peer-Reviewed Original ResearchConceptsGut microbiome profilesHepatic encephalopathyGut microbiota testMicrobial speciesMicrobiome profilesTraining cohortValidation cohortHE diagnosisStool microbiotaMulticenter prospective cohortDiagnosis of hepatic encephalopathyMulticenter validation cohortNeuropsychological testsNanopore analysisSemi-quantitative questionnaireGutStandard neuropsychological testsProspective cohortIdentified patientsPatientsGold standardCohortDisease processCognitive complaintsDiagnosisHospitalized patients with cirrhosis: Addressing gaps in care
Batisti J, Jakab S. Hospitalized patients with cirrhosis: Addressing gaps in care. Clinical Liver Disease 2024, 23: e0211. PMID: 38961874, PMCID: PMC11221856, DOI: 10.1097/cld.0000000000000211.Peer-Reviewed Original ResearchLetter to the Editor: Survey of attitudes and knowledge of early paracentesis guidelines and performance in providers in the Veterans Health Administration
Giustini A, Patel A, Cheung R, Nobbe A, Perumalswami P, Johnson R, Jakab S, Patton H, Morgan T, O’Leary J, Bajaj J, Rogal S. Letter to the Editor: Survey of attitudes and knowledge of early paracentesis guidelines and performance in providers in the Veterans Health Administration. Liver Transplantation 2024, 30: e48-e49. PMID: 38920367, DOI: 10.1097/lvt.0000000000000426.Peer-Reviewed Original Research869 GUT MICROBIOME PROFILE THROUGH MACHINE LEARNING ALGORITHMS CLARIFIES HEPATIC ENCEPHALOPATHY DIAGNOSES IN A MULTI-CENTER CIRRHOSIS COHORT
Bajaj J, O'Leary J, Jakab S, Chong N, Sikaroodi M, Gillevet P. 869 GUT MICROBIOME PROFILE THROUGH MACHINE LEARNING ALGORITHMS CLARIFIES HEPATIC ENCEPHALOPATHY DIAGNOSES IN A MULTI-CENTER CIRRHOSIS COHORT. Gastroenterology 2024, 166: s-200-s-201. DOI: 10.1016/s0016-5085(24)00954-5.Peer-Reviewed Original Research
2023
Hospital Utilization for Patients With Cirrhosis and Severe Ascites in a Model of Outpatient Paracentesis by Interventional Radiology
Ahmed M, Islam M, Gogokhia L, Borz-Baba C, Wakefield D, Jakab S. Hospital Utilization for Patients With Cirrhosis and Severe Ascites in a Model of Outpatient Paracentesis by Interventional Radiology. Cureus 2023, 15: e51397. PMID: 38292997, PMCID: PMC10826452, DOI: 10.7759/cureus.51397.Peer-Reviewed Original ResearchSpontaneous bacterial peritonitisAcute kidney injuryOutpatient paracentesisICU admissionInterventional radiologistsHospital utilizationCirrhosis complicationsKidney injuryHospital admissionClinical outcomesEnd-stage liver diseaseTertiary academic medical centerGastroenterologists/hepatologistsTime of paracentesisAlcohol-related cirrhosisComplications of cirrhosisUpper gastrointestinal bleedingEmergency department visitsEvaluation of patientsCurrent practice guidelinesTransjugular portosystemic shuntModel of careAcademic medical centerWilcoxon rank sum testChi-square test
2007
Mycophenolate mofetil for drug-induced vanishing bile duct syndrome.
Jakab SS, West AB, Meighan DM, Brown RS, Hale WB. Mycophenolate mofetil for drug-induced vanishing bile duct syndrome. World Journal Of Gastroenterology 2007, 13: 6087-9. PMID: 18023105, PMCID: PMC4250896, DOI: 10.3748/wjg.v13.45.6087.Peer-Reviewed Original ResearchConceptsBile duct syndromeAmoxicillin/clavulanateMycophenolate mofetilLow-dose mycophenolate mofetilSequential liver biopsiesInosine monophosphate dehydrogenase inhibitorSustained remissionCholestatic patternImmunosuppressive therapyElderly patientsProlonged cholestasisLiver biopsyLiver injuryMofetilPatientsComplete withdrawalAzathioprineSyndromeClavulanateDehydrogenase inhibitorCirrhosisCorticosteroidsPrednisoneRemissionCholestasis
Others
- Jakab SS, Clayton M, Herrine SK, Navarro VJ, Feitelson M. Expression of HBx-Regulated Genes Is Not Limited To HBV-Related Hepatocellular Carcinoma. Oral presentation, Komarov Competition, Philadelphia, March 2006Peer-Reviewed Original Research
- Jakab SS, Mitroo P, Rubin R, Herrine SK, Navarro VJ. Extensive Intrahepatic Cholelithiasis with Large Biliary Abscesses. Poster presentation, ACG National Fellows Forum, Reston, VA, June 2006Peer-Reviewed Original Research
- Jakab SS, Navarro VJ, Colombe BW, Daskalakis C, Herrine SK, Rossi S. The Impact of HLA Match on Living-Donor Liver Transplantation Outcomes: An Analysis of the United Network for Organ Sharing Database. Liver Transplantation. 2007 Oct;13(10): 1405-13.Peer-Reviewed Original Research
- Gaglio PJ, Jakab SS, Novogrudsky A, Emond JC, Lefkowitch J, Brown RS Jr. Hepatitis C Recurrence Following Liver Transplantation: Does Histologic Severity of Inflammation in the Explant Correlate with Recurrence? Poster presentation, 2004 American Transplant Congress, Boston, MA.Peer-Reviewed Original Research
Clinical Trials
Current Trials
A Phase 3 Study Evaluating Long-term Efficacy and Safety of Lanifibranor in Adult Patients With (NASH) and Fibrosis 2 (F2)/Fibrosis 3 (F3) Stage of Liver Fibrosis (NATiV3)
HIC ID2000030905RoleSub InvestigatorPrimary Completion Date02/28/2024Recruiting ParticipantsGenderBothAge18+ yearsMetabolic Interventions to Resolve Non-alcoholic Steatohepatitis (NASH) With Fibrosis (MIRNA) (MIRNA)
HIC ID2000027577RoleSub InvestigatorPrimary Completion Date11/01/2022Recruiting ParticipantsGenderBothAge18 years - 75 years
Academic Achievements & Community Involvement
Clinical Care
Overview
Simona Jakab, MD, specializes in digestive diseases. Her clinical focus is on treating liver and liver-related conditions, such as ascites, nonalcoholic fatty liver disease (NAFLD), alcoholic cirrhosis, chronic liver disease, alcoholic hepatitis, acute and chronic liver failure, and hepatic encephalopathy. She is the firm chief of the Klatskin Liver Service in internal medicine.
In addition to her clinical work, Dr. Jakab’s research interests include cirrhosis and varices management, hepatic encephalopathy, hepatitis and liver transplantation, gastroenterology in the Department of Veterans Affairs, and pre-liver transplant dental protocols. Her work has also explored the side effects of hepatitis C medications and the relationship between hepatitis B exposure and the development of liver and pancreatic cancer.
A recipient of the Edwin C. Cadman Award, Dr. Jakab is an associate professor of medicine at Yale School of Medicine.
Clinical Specialties
Hepatology
Fact Sheets
Cirrhosis
Learn More on Yale MedicineHepatitis B and C
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Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States
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