Key Role of Porcine Cytochrome P450 2A19 in the Bioactivation of Aflatoxin B1 in the Liver
Wang Z, Huang Q, Zhang F, Wu J, Wang L, Sun Y, Deng Y, Jiang J. Key Role of Porcine Cytochrome P450 2A19 in the Bioactivation of Aflatoxin B1 in the Liver. Journal Of Agricultural And Food Chemistry 2024, 72: 2334-2346. PMID: 38235998, DOI: 10.1021/acs.jafc.3c08663.Peer-Reviewed Original ResearchConceptsDNA damagePorcine liver microsomesStable cell linesN297A mutantProducts of AFB<sub>1</sub>Aflatoxin B<sub>1</sub>Cell deathCYP2A19DNACell linesCytochrome P450 (CYP)3ACatalytic activityProtein levelsBioactivation of aflatoxin B1Metabolic activityAdduct formationCellsMetabolic transformationAdductsLiver microsomesMutantsAFBOCYP3A46Aflatoxin B1Human-based research
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