2020
Acute Hepatic Failure
Ghosh S, Bassily‐Marcus A. Acute Hepatic Failure. 2020, 359-364. DOI: 10.1002/9781119293255.ch39.Peer-Reviewed Original ResearchCause of acute hepatic failureAcute hepatic failureHepatic failurePredictor of liver transplantationPre-existing liver diseaseDegree of hepatic encephalopathyDrug-induced hepatitisTime of presentationNational society guidelinesTreatment of acute hepatic failureLife-threatening critical illnessLiver transplantationViral hepatitisAcetaminophen toxicitySociety guidelinesHepatic encephalopathyLiver diseaseCritical illnessMortality rateHealthy young adultsHepatitisYoung adultsPrimary causePrognosisTransplantationA novel escalation from veno-venous bypass to veno-venous ECMO during orthotopic liver transplantation. A case report
Voulgarelis S, Hong J, Zimmerman M, Kim J, Scott J. A novel escalation from veno-venous bypass to veno-venous ECMO during orthotopic liver transplantation. A case report. Perfusion 2020, 36: 861-863. PMID: 33200657, DOI: 10.1177/0267659120973592.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenationLiver transplantationVeno-venous extracorporeal membrane oxygenationExtracorporeal CO<sub>2</sub> removalOrthotopic liver transplantationVeno-veno bypassPerioperative courseMembrane oxygenationReduce bleedingImprove oxygenationHepatic failureAcid base balanceCollateral circulationDocumented caseOptimal preloadTransplantationPatientsBase balanceBiochemistry profileExtracorporeal devicesBleedingInherited diseases of copper metabolism: Wilson’s disease and Menkes’ disease
Schilsky M, Mistry P. Inherited diseases of copper metabolism: Wilson’s disease and Menkes’ disease. 2020, 2115-2120. DOI: 10.1093/med/9780198746690.003.0234.Peer-Reviewed Original ResearchLiver diseaseCopper excretionHigh urinary copper excretionWilson's diseaseDecompensated liver diseasePrevious affected siblingFulminant hepatic failureUrinary copper excretionKayser-Fleischer ringsConnective tissue disordersLow serum ceruloplasminAge 3 yearsFunction mutationsDefective copper transportAutosomal recessive lossLiver copper contentSingle biochemical testFlorid presentationLiver transplantationHepatic failureMedical therapyClinical presentationClinical findingsUncommon disorderTypical presentationGenotype‐phenotype correlation and molecular heterogeneity in pyruvate kinase deficiency
Bianchi P, Fermo E, Lezon‐Geyda K, van Beers E, Morton HD, Barcellini W, Glader B, Chonat S, Ravindranath Y, Newburger PE, Kollmar N, Despotovic JM, Verhovsek M, Sharma M, Kwiatkowski JL, Kuo KHM, Wlodarski MW, Yaish HM, Holzhauer S, Wang H, Kunz J, Addonizio K, Al‐Sayegh H, London WB, Andres O, van Wijk R, Gallagher PG, Grace RFF. Genotype‐phenotype correlation and molecular heterogeneity in pyruvate kinase deficiency. American Journal Of Hematology 2020, 95: 472-482. PMID: 32043619, PMCID: PMC8127999, DOI: 10.1002/ajh.25753.Peer-Reviewed Original ResearchConceptsNon-missense mutationsPyruvate kinase deficiencyRare severe complicationsFrequency of complicationsLower extremity ulcerationsLower hemoglobin levelsKinase deficiencyNatural history studiesDifferent pathogenic variantsTerms of hemoglobinCongenital hemolytic anemiaGenotype-phenotype correlationLifetime transfusionsDeficient womenPregnancy outcomesPulmonary hypertensionSevere complicationsSplenectomy statusHemoglobin levelsHepatic failureNewborn periodClinical similaritiesWide genetic heterogeneityIron overloadHemolytic anemia
2019
Endovascular Treatment of Inferior Vena Cava Thrombosis in Metastatic Malignancy: A Case Report and Review of Literature
Shapero KS, Jelani QU, Mena C. Endovascular Treatment of Inferior Vena Cava Thrombosis in Metastatic Malignancy: A Case Report and Review of Literature. Vascular And Endovascular Surgery 2019, 53: 507-511. PMID: 31216954, DOI: 10.1177/1538574419857992.Peer-Reviewed Original ResearchConceptsInferior vena cava thrombosisLower extremity edemaVena cava thrombosisAcute liver failureRight atriumIVC thrombosisCava thrombosisExtremity edemaLiver failureSevere bilateral lower extremity edemaBilateral lower extremity edemaAdrenal cell carcinomaExtensive clot burdenExtensive IVC thrombosisMetastatic liver massesDeep vein thrombosisClot burdenIVC syndromeReview of literatureGastrointestinal bleedHospital courseVein thrombosisHepatic failureCaudate lobeEndovascular treatmentSUN-019 The Selective Progesterone Receptor Modulator Ulipristal Acetate Blocks Glucocorticoid Receptor Transactivation
Smalls B, Millard C, Kisanga E, Flannery C, Al-Hendy A, Whirledge S. SUN-019 The Selective Progesterone Receptor Modulator Ulipristal Acetate Blocks Glucocorticoid Receptor Transactivation. Journal Of The Endocrine Society 2019, 3: sun-019. PMCID: PMC6553416, DOI: 10.1210/js.2019-sun-019.Peer-Reviewed Original ResearchSelective progesterone receptor modulatorsAnti-glucocorticoid activityUlipristal acetateGlucocorticoid receptorEffect of UPAHuman uterine fibroid tissueLong-term therapeutic agentGR antagonist RU-486Progesterone receptor modulatorsAntagonist RU 486Post-marketing analysisGlucocorticoid-induced expressionLower glucocorticoid receptorUterine fibroid tissueEndogenous glucocorticoid receptorSynthetic glucocorticoid dexamethasoneCell linesUterine fibroid cellsHuman uterine fibroid cellsFemale reproductive systemUtLM cellsHepatic failureLiver injuryPR expressionTherapeutic options
2017
Dual Organ Duel: The Hepatorenal Axis
Golestaneh L, Neugarten J. Dual Organ Duel: The Hepatorenal Axis. Advances In Kidney Disease And Health 2017, 24: 253-260. PMID: 28778366, DOI: 10.1053/j.ackd.2017.05.009.Peer-Reviewed Original ResearchConceptsKidney injuryLiver failureAntiviral therapy of patientsHepatitis C antiviral therapyKidney diseaseTherapeutic strategiesMarker of systemic diseaseAcute kidney injuryTherapy of patientsKidney risk factorsTargeted therapeutic strategiesPathogenesis of kidney diseaseWorsening hepatic failurePortal hypertensionAntiviral therapyHepatitis CBiopsy dataPoor prognosisAltered pharmacodynamicsDifferential diagnosisHepatic failurePathophysiological mechanismsSystemic diseaseRisk factorsClinical potential
2015
Drug-induced fulminant hepatic failure in pregnancy
Firoz T, Webber D, Rowe H. Drug-induced fulminant hepatic failure in pregnancy. Obstetric Medicine 2015, 8: 190-192. PMID: 27512479, PMCID: PMC4935052, DOI: 10.1177/1753495x15598909.Peer-Reviewed Original ResearchFulminant hepatic failureHepatic failureLiver failureGestational ageLiver diseaseDrug-induced liver injuryAbnormal liver functionWeeks gestational agePregnant patientsElevated liverLiver biopsyLiver injuryLiver functionSignificant causePregnancyPatientsMedicationsLabetalolMethyldopaDiseaseFailureCauseJaundiceBiopsyHepatotoxicityFulminant Hepatic Failure Secondary to Primary Hepatic Angiosarcoma
Abegunde A, Aisien E, Mba B, Chennuri R, Sekosan M. Fulminant Hepatic Failure Secondary to Primary Hepatic Angiosarcoma. Case Reports In Gastrointestinal Medicine 2015, 2015: 869746. PMID: 25815217, PMCID: PMC4359886, DOI: 10.1155/2015/869746.Peer-Reviewed Original ResearchPrimary hepatic angiosarcomaHepatic angiosarcomaHepatic failureRapidity of progressionFulminant hepatic failureOnset of symptomsLimited treatment optionsEarly diagnostic strategiesReview of literatureNonspecific symptomsHealthy menTreatment optionsAggressive tumorsCase reportNew therapiesAngiosarcomaAdvanced stageDiagnostic strategiesTwo monthsSymptomsJaundicePatientsFailurePrognosisMalignancy
2012
Short-Term Outcomes of Ablation Therapy for Hepatic Tumors: Evidence from the 2006–2009 Nationwide Inpatient Sample
Fox JP, Gustafson J, Desai MM, Hellan M, Thambi-Pillai T, Ouellette J. Short-Term Outcomes of Ablation Therapy for Hepatic Tumors: Evidence from the 2006–2009 Nationwide Inpatient Sample. Annals Of Surgical Oncology 2012, 19: 3677-3686. PMID: 22588470, DOI: 10.1245/s10434-012-2397-0.Peer-Reviewed Original ResearchConceptsProcedure-specific complicationsNationwide Inpatient SampleMetastatic liver tumorsOpen surgical approachHepatic tumorsPostoperative complicationsSurgical approachInpatient SampleLiver tumorsMultivariable logistic regression analysisTreatment-related morbidityCases/yearLogistic regression analysisResultsMost patientsTransfusion requirementsHospital morbidityAdverse eventsIntraoperative bleedingBackgroundRadiofrequency ablationHeart failureHepatic failurePatient factorsTerm outcomesLaparoscopic proceduresAblation therapy
2011
Fatal Rhabdomyolysis in a Patient with Liver Cirrhosis after Switching from Simvastatin to Fluvastatin
Baek S, Jang S, Park S, Ok T, Leem J, Lee H, Park S, Kim T. Fatal Rhabdomyolysis in a Patient with Liver Cirrhosis after Switching from Simvastatin to Fluvastatin. Journal Of Korean Medical Science 2011, 26: 1634-1637. PMID: 22148003, PMCID: PMC3230026, DOI: 10.3346/jkms.2011.26.12.1634.Peer-Reviewed Original ResearchConceptsFatal rhabdomyolysisLiver cirrhosisContinuous renal replacement therapyAcute renal failureRenal replacement therapyCoronary artery diseaseHMG-CoA reductase inhibitorsSerum creatine kinaseAsymptomatic elevationIntravenous furosemideRenal failureUrine alkalizationArtery diseaseHepatic failureReplacement therapyMassive hydrationRhabdomyolysisPatientsCirrhosisReductase inhibitorsCreatine kinaseAdverse effectsSimvastatinFluvastatinCandesartanAutoimmune Hepatitis: A Review of Current Diagnosis and Treatment
Makol A, Watt KD, Chowdhary VR. Autoimmune Hepatitis: A Review of Current Diagnosis and Treatment. Hepatitis Research And Treatment 2011, 2011: 390916. PMID: 21760995, PMCID: PMC3132488, DOI: 10.1155/2011/390916.Peer-Reviewed Original ResearchAutoimmune hepatitisTreatment end pointsClinical presentationEnd pointChronic indolent diseaseDate diagnostic criteriaEarly liver transplantationNormal liver testsAlternative immunosuppressive agentsImmune-mediated attackLong-term prognosisChronic inflammatory disordersFulminant hepatic failureDiverse clinical manifestationsAggressive initiationAIH patientsCorticosteroid therapyElevated immunoglobulinsLiver testsLiver transplantationHepatic failurePeriportal inflammationImmunosuppressive agentsIndolent diseaseLiver disease
2010
Portal Vein Embolization Prior to Resection
Madoff D, Avritscher R. Portal Vein Embolization Prior to Resection. 2010, 153-183. DOI: 10.1007/978-1-60327-522-4_11.Peer-Reviewed Original ResearchFuture liver remnantFunctional liver massHepatic failureLiver massNormal underlying liverExtended hospital stayMajor hepatic resectionChronic liver diseasePortal vein embolizationMajor technical complicationsFatal hepatic failureImportant risk factorPerioperative failureHospital stayHepatic resectionVein embolizationPerioperative careLiver diseaseUnderlying liverLiver remnantFluid retentionHepatobiliary neoplasiaRisk factorsHigh riskResection
2009
Liver dysfunction in pregnancy: an important cause of maternal and perinatal morbidity and mortality in Pakistan
Hossain N, Shamsi T, Kuczynski E, Lockwood C, Paidas M. Liver dysfunction in pregnancy: an important cause of maternal and perinatal morbidity and mortality in Pakistan. Obstetric Medicine 2009, 2: 17-20. PMID: 27582800, PMCID: PMC4989777, DOI: 10.1258/om.2008.080028.Peer-Reviewed Original ResearchFulminant hepatic failureLiver dysfunctionHepatitis EMaternal deathsPregnant womenStudy populationProspective observational study designAcute hepatitis EOverall perinatal mortalityUnderwent caesarean sectionAcute fatty liverAbnormal coagulation parametersCivil Hospital KarachiObservational study designHELLP syndromeHospital KarachiPerinatal morbidityPerinatal outcomesCaesarean sectionHepatic failureHepatitis A.Perinatal mortalityFatty liverThird trimesterSecond trimester
2008
Delayed intravascular haemolysis following multiple asymptomatic ABO‐incompatible red blood cell transfusions in a patient with hepatic failure
Tormey CA, Stack G. Delayed intravascular haemolysis following multiple asymptomatic ABO‐incompatible red blood cell transfusions in a patient with hepatic failure. Vox Sanguinis 2008, 95: 232-235. PMID: 19121188, DOI: 10.1111/j.1423-0410.2008.01085.x.Peer-Reviewed Original ResearchConceptsABO-incompatible red blood cell (RBC) transfusionsRed blood cell transfusionBlood cell transfusionFresh frozen plasmaCell transfusionHepatic failureDelayed Haemolytic Transfusion ReactionAnamnestic antibody responseLow complement levelsHaemolytic transfusion reactionsOnset of haemolysisFirst transfusionRBC transfusionComplement levelsIncompatible transfusionsAntibody responseAntibody titresHepatic diseaseTransfusion reactionsIntravascular haemolysisTransfusionPatientsRBC unitsB RBCsHaemolysis
2007
A Case of Metastatic Adenocarcinoma Presenting with Fulminant Hepatic Failure and Elevated Alpha Fetoprotein Level
Sivaprakasapillai N, Fayad N, Chaptini L, Deitch C, Depenbusch J. A Case of Metastatic Adenocarcinoma Presenting with Fulminant Hepatic Failure and Elevated Alpha Fetoprotein Level. The American Journal Of Gastroenterology 2007, 102: s375. DOI: 10.14309/00000434-200709002-00699.Peer-Reviewed Case Reports and Technical NotesHepatocyte‐specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure
Chen Y, Yang Y, Miller ML, Shen D, Shertzer HG, Stringer KF, Wang B, Schneider SN, Nebert DW, Dalton TP. Hepatocyte‐specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure. Hepatology 2007, 45: 1118-1128. PMID: 17464988, DOI: 10.1002/hep.21635.Peer-Reviewed Original ResearchConceptsLiver failureMitochondrial injuryLiver biochemistry testsSevere parenchymal damageNumerous liver diseasesMonths of ageGCLC geneHepatic failureLiver injuryParenchymal damageLiver diseaseDepletion of glutathioneHepatic steatosisHistological featuresGSH synthesisHepatic functionPostnatal dayHepatocyte deathKnockout miceRapid onsetBiochemistry testsHepatic GSHSteatosisUltrastructural examinationOxidative stress
1999
Wilson’s disease
Tavill A, Schilsky M. Wilson’s disease. Current Treatment Options In Gastroenterology 1999, 2: 68-71. PMID: 11096575, DOI: 10.1007/s11938-999-0021-6.Peer-Reviewed Original ResearchPharmacologic therapyWilson's diseaseOrthotopic liver transplantationFulminant hepatic failureLiver transplantationCompliant patientsPreventive therapyHepatic failureHepatic insufficiencyMedical therapyOrgan damageMaintenance treatmentTherapyPatientsDiseaseTransplantationPrognosisInsufficiencyDiagnosis
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