2020
The Role of FER rs4957796 in the Risk of Developing and Dying from a Bloodstream Infection: A 23-Year Follow-up of the Population-based Nord-Trøndelag Health Study
Rogne T, Damås JK, Flatby HM, Åsvold BO, DeWan AT, Solligård E. The Role of FER rs4957796 in the Risk of Developing and Dying from a Bloodstream Infection: A 23-Year Follow-up of the Population-based Nord-Trøndelag Health Study. Clinical Infectious Diseases 2020, 73: e297-e303. PMID: 32699877, PMCID: PMC8282309, DOI: 10.1093/cid/ciaa786.Peer-Reviewed Original ResearchConceptsBloodstream infectionsHUNT StudyCC genotypePopulation-based HUNT StudyBloodstream infection incidenceBloodstream infection patientsTotal study populationTerms of mortalityInfection patientsSepsis mortalityCase fatalityImmunoregulatory roleDiagnosis codesProspective dataStudy populationTT genotypeBlood samplesInfection incidencePatientsC alleleInfectionMajor causeHealth lossMortalitySingle nucleotide polymorphisms
2018
A genetic variant in IL‐15Rα correlates with physical activity among European–American adults
Bruneau M, Walsh S, Selinsky E, Ash G, Angelopoulos TJ, Clarkson P, Gordon P, Moyna N, Visich P, Zoeller R, Thompson P, Gordish‐Dressman H, Hoffman E, Devaney J, Pescatello LS. A genetic variant in IL‐15Rα correlates with physical activity among European–American adults. Molecular Genetics & Genomic Medicine 2018, 6: 401-408. PMID: 29624921, PMCID: PMC6014439, DOI: 10.1002/mgg3.368.Peer-Reviewed Original ResearchConceptsPhysical activity phenotypesMuscle strengthPhysical activityPaffenbarger Physical Activity QuestionnaireLight-intensity physical activityHabitual physical activityPhysical Activity QuestionnaireIntensity physical activityActivity phenotypesInterleukin-15Activity QuestionnaireResistance trainingCC genotypeAnalysis of covarianceProtein breakdownEuropean American adultsMenPhenotypeGenotypesMyokinesBMIWomen
2016
IL4 gene polymorphisms in Iranian patients with autoimmune hepatitis
Yousefi A, Mahmoudi E, Bidoki A, Varzaneh F, Noveiry B, Sadr M, Motamed F, Najafi M, Farahmand F, Rezaei N. IL4 gene polymorphisms in Iranian patients with autoimmune hepatitis. Expert Review Of Gastroenterology & Hepatology 2016, 10: 659-663. PMID: 26735262, DOI: 10.1586/17474124.2016.1139449.Peer-Reviewed Original ResearchConceptsAutoimmune hepatitisC alleleAssociation of autoimmune hepatitisMechanisms of autoimmune hepatitisAutoimmune hepatitis patientsAllelic polymorphismInvestigate potential associationsPotential therapeutic interventionsHepatocellular inflammationAuto-antibodiesTT genotypeCC genotypeGene polymorphismsIranian patientsIL4 geneGene variantsIL4RA geneSusceptibility genesIL4Therapeutic interventionsHepatitisPatientsGenetic componentGenesPolymorphism
2014
Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans
Laffer CL, Elijovich F, Eckert GJ, Tu W, Pratt JH, Brown NJ. Genetic variation in CYP4A11 and blood pressure response to mineralocorticoid receptor antagonism or ENaC inhibition: an exploratory pilot study in African Americans. International Journal Of Cardiology Cardiovascular Risk And Prevention 2014, 8: 475-480. PMID: 25064769, PMCID: PMC4115247, DOI: 10.1016/j.jash.2014.04.011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBlack or African AmericanBlood PressureCytochrome P-450 CYP4ACytochrome P-450 Enzyme SystemDNADouble-Blind MethodFemaleGenetic VariationGenotypeHumansHypertensionMaleMiddle AgedMineralocorticoid Receptor AntagonistsPilot ProjectsRadioimmunoassayUnited StatesYoung AdultConceptsBlood pressure responseBlood pressureReceptor antagonismPressure responseMineralocorticoid receptor antagonismSalt-sensitive hypertensionAfrican AmericansExploratory pilot studyGC individualsAldosterone responseResistant hypertensionAntihypertensive effectTreatment responsePrecluded analysisCC genotypeCC homozygotesSpironolactoneC alleleHypertensionPilot studyENaC activationCYP4A11AmilorideActivation of ENaC.ENaC inhibition
2012
CC genotype donors for the interleukin‐28B single nucleotide polymorphism are associated with better outcomes in hepatitis C after liver transplant
Firpi R, Dong H, Clark V, Soldevila‐Pico C, Morelli G, Cabrera R, Norkina O, Shuster J, Nelson D, Liu C. CC genotype donors for the interleukin‐28B single nucleotide polymorphism are associated with better outcomes in hepatitis C after liver transplant. Liver International 2012, 33: 72-78. PMID: 23107586, PMCID: PMC3518691, DOI: 10.1111/liv.12013.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntiviral AgentsBiopsyFemaleFloridaGenotypeHepatitis CHumansInterferonsInterleukinsKaplan-Meier EstimateLiver CirrhosisLiver TransplantationLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPolymorphism, Single NucleotideProportional Hazards ModelsRecurrenceRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTissue DonorsTreatment OutcomeConceptsSustained viral responseInterferon-based therapyLiver transplant patientsCC genotypeRecurrent HCVLiver transplantTransplant patientsIL-28B single nucleotide polymorphismInterleukin (IL) 28B single nucleotide polymorphismsAdult liver transplant patientsPost-transplant HCV recurrenceHepatitis C populationIL-28B genotypeIL-28B polymorphismsInterleukin 28B (IL28B) polymorphismsStrongest pretreatment predictorOverall clinical outcomeBetter treatment responseSingle nucleotide polymorphismsHCV recurrenceHCV patientsHCV therapyLiver transplantationHepatitis COverall survival
2011
Genetic Variation in Base Excision Repair Pathway Genes, Pesticide Exposure, and Prostate Cancer Risk
Barry KH, Koutros S, Berndt SI, Andreotti G, Hoppin JA, Sandler DP, Burdette LA, Yeager M, Freeman LE, Lubin JH, Ma X, Zheng T, Alavanja MC. Genetic Variation in Base Excision Repair Pathway Genes, Pesticide Exposure, and Prostate Cancer Risk. Environmental Health Perspectives 2011, 119: 1726-1732. PMID: 21810555, PMCID: PMC3261977, DOI: 10.1289/ehp.1103454.Peer-Reviewed Original ResearchConceptsProstate cancer riskCancer riskSingle nucleotide polymorphismsPesticide applicatorsCT/TT genotypesPesticide manufacturing workersCase-control studyProstate cancer casesLogistic regression modelsTag single nucleotide polymorphismsBase excision repair pathway genesProstate cancerCancer casesFamily historyOxidative DNA damageTT genotypeCC genotypeMale controlsExposure variablesPesticide exposureBase excision repairManufacturing workersUnderlying mechanismRiskBER genes
2010
A Functional Polymorphism in Renalase (Glu37Asp) Is Associated with Cardiac Hypertrophy, Dysfunction, and Ischemia: Data from the Heart and Soul Study
Farzaneh-Far R, Desir GV, Na B, Schiller NB, Whooley MA. A Functional Polymorphism in Renalase (Glu37Asp) Is Associated with Cardiac Hypertrophy, Dysfunction, and Ischemia: Data from the Heart and Soul Study. PLOS ONE 2010, 5: e13496. PMID: 20975995, PMCID: PMC2958117, DOI: 10.1371/journal.pone.0013496.Peer-Reviewed Original ResearchConceptsPoor exercise capacityExercise capacityInducible ischemiaCardiac hypertrophyDiastolic dysfunctionSystolic dysfunctionStable coronary artery diseaseMissense polymorphismTreadmill exercise capacityCoronary artery diseaseSoul StudyVentricular dysfunctionArtery diseaseVentricular hypertrophyStress echocardiographyCommon missense polymorphismCC genotypeIschemiaTherapeutic implicationsCG genotypeCardiac structureDysfunctionHypertrophyRenalaseLogistic regression
2006
E‐cadherin promoter polymorphism (C‐160A) and risk of recurrence in patients with superficial bladder cancer
Lin J, Dinney C, Grossman H, Jhamb M, Zhu Y, Spitz, Wu X. E‐cadherin promoter polymorphism (C‐160A) and risk of recurrence in patients with superficial bladder cancer. Clinical Genetics 2006, 70: 240-245. PMID: 16922727, DOI: 10.1111/j.1399-0004.2006.00666.x.Peer-Reviewed Original ResearchConceptsSuperficial bladder cancerBladder cancer recurrenceBladder cancerCancer recurrencePromoter polymorphismHazard ratioCaucasian patientsMedian recurrence-free survivalMedical chart reviewRecurrence-free survivalRisk of recurrencePeripheral blood lymphocytesProportional hazards modelHomozygous CC genotypeChart reviewDisease recurrenceSmoking statusTumor recurrenceTumor stageBlood lymphocytesClinical dataCC genotypeHazards modelPatientsRecurrence risk
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