2018
Cellular localization of PD-L1 expression in mismatch-repair-deficient and proficient colorectal carcinomas
Liu S, Gӧnen M, Stadler Z, Weiser M, Hechtman J, Vakiani E, Wang T, Vyas M, Joneja U, Al-Bayati M, Segal N, Smith J, King S, Guercio S, Ntiamoah P, Markowitz A, Zhang L, Cercek A, Garcia-Aguilar J, Saltz L, Diaz L, Klimstra D, Shia J. Cellular localization of PD-L1 expression in mismatch-repair-deficient and proficient colorectal carcinomas. Modern Pathology 2018, 32: 110-121. PMID: 30166615, PMCID: PMC6309293, DOI: 10.1038/s41379-018-0114-7.Peer-Reviewed Original ResearchConceptsPD-L1 expressionMismatch repair-proficient tumorsImmune cell stainingMismatch repair-deficient tumorsPD-L1Tumor-infiltrating-lymphocytesColorectal carcinomaTumor cellsImmune cell PD-L1 expressionMismatch repair-deficient colorectal carcinomasTreatment of colorectal carcinomaMolecular sub-classificationLigand PD-L1Mismatch repair-deficient colorectal cancerHigher lymphocyte countMismatch repair-proficientCell stainingCellular localizationPD-1Mismatch repair deficiencyPredictive biomarkersLymphocyte countMolecular subtypesClinical efficacyTumor types
2017
Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions
Hechtman J, Benayed R, Hyman D, Drilon A, Zehir A, Frosina D, Arcila M, Dogan S, Klimstra D, Ladanyi M, Jungbluth A. Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions. The American Journal Of Surgical Pathology 2017, 41: 1547-1551. PMID: 28719467, PMCID: PMC5636652, DOI: 10.1097/pas.0000000000000911.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBiopsyDNA Copy Number VariationsFemaleGene DosageGene FusionGene RearrangementGenetic Predisposition to DiseaseHumansImmunohistochemistryMaleMembrane GlycoproteinsMutationNeoplasmsPhenotypePredictive Value of TestsProspective StudiesReceptor, trkAReceptor, trkBReceptor, trkCReceptors, Nerve Growth FactorReproducibility of ResultsSequence Analysis, DNAConceptsNeurotrophic tyrosine receptor kinasePan-TRK immunohistochemistryNTRK fusionsETV6-NTRK3 fusionNTRK rearrangementsMembrane accentuationETV6-NTRK3Fusion transcriptsDNA-based next-generation sequencing assaysMismatch repair-deficient colorectal carcinomasCase of secretory carcinomaDetection of NTRK fusionsDetect NTRK fusionsNext-generation sequencing assayLMNA-NTRK1 fusionTyrosine receptor kinaseFunctional fusion transcriptsPositive IHC casesPan-TrkIHC casesSecretory carcinomaAdvanced malignanciesCongenital fibrosarcomaMSK-IMPACTLMNA-NTRK1
2016
Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma
Lee L, Cavalcanti M, Segal N, Hechtman J, Weiser M, Smith J, Garcia-Aguilar J, Sadot E, Ntiamoah P, Markowitz A, Shike M, Stadler Z, Vakiani E, Klimstra D, Shia J. Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma. Modern Pathology 2016, 29: 1433-1442. PMID: 27443512, PMCID: PMC5083129, DOI: 10.1038/modpathol.2016.139.Peer-Reviewed Original ResearchConceptsProgrammed death-ligand 1PD-1-positive tumor-infiltrating lymphocytesProgrammed death-ligand 1 expressionTumor-infiltrating lymphocytesProgrammed death-1Mismatch repair-deficient colorectal carcinomasRecurrence-free survivalAnti-PD-1 therapyPD-L1 expressionColorectal carcinomaMismatch repair-deficient tumorsPredictive markerPrognostic impact of tumor-infiltrating lymphocytesResponse to anti-PD-1 therapyHigh programmed death ligand-1Impact of tumor-infiltrating lymphocytesProgrammed death ligand 1 levelPD-1 levelsTumor PD-L1 expressionProgrammed death-1 expressionAssociated with better prognosisMismatch repair-proficient tumorsImmune checkpoint blockadePD-1 expressionPD-L1 immunohistochemistry
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