2019
Adverse Histologic Features in Colorectal Nonpedunculated Malignant Polyps With Nodal Metastasis
Patel N, Vyas M, Celli R, Jain D, Zhang X. Adverse Histologic Features in Colorectal Nonpedunculated Malignant Polyps With Nodal Metastasis. The American Journal Of Surgical Pathology 2019, 44: 241-246. PMID: 31498179, DOI: 10.1097/pas.0000000000001369.Peer-Reviewed Original ResearchConceptsHigh-grade tumor buddingAdverse histologic featuresMalignant polypsNodal metastasisTumor buddingHistologic featuresLymphovascular invasionNode metastasisLymph node metastatic potentialMargin statusSubsequent resectionColectomy specimenColectomy proceduresDifferentiated clustersTumor differentiationOdds ratioRisk featuresMetastasisMetastatic potentialPiecemeal polypectomyPolypsRiskInvasionColectomyResection
2018
Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations
Druliner B, Wang P, Bae T, Baheti S, Slettedahl S, Mahoney D, Vasmatzis N, Xu H, Kim M, Bockol M, O’Brien D, Grill D, Warner N, Munoz-Gomez M, Kossick K, Johnson R, Mouchli M, Felmlee-Devine D, Washechek-Aletto J, Smyrk T, Oberg A, Wang J, Chia N, Abyzov A, Ahlquist D, Boardman L. Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations. Scientific Reports 2018, 8: 3161. PMID: 29453410, PMCID: PMC5816667, DOI: 10.1038/s41598-018-21525-4.Peer-Reviewed Original ResearchConceptsColorectal cancerManagement of polypsPolyp patientsPolyp groupMalignant polypsPrecursor lesionsColorectal adenomasResidual polypPolyp tissuesPolyp sizePolypsCancerAltered expressionMethylome alterationsPatientsWhole-genome sequencingTissueMore mutationsAlterationsExpression changesSignificant expression changesMolecular determinantsMethylation alterationsMolecular distinctionMolecular characterization
2017
Outcomes following polypectomy for malignant colorectal polyps are similar to those following surgery in the general population
Lopez A, Bouvier A, Jooste V, Cottet V, Romain G, Faivre J, Manfredi S, Lepage C. Outcomes following polypectomy for malignant colorectal polyps are similar to those following surgery in the general population. Gut 2017, 68: 111. PMID: 29074726, DOI: 10.1136/gutjnl-2016-312093.Peer-Reviewed Original ResearchConceptsSessile malignant polypsColorectal malignant polypsMalignant polypsPathological marginsEndoscopic resectionSurgical resectionRecurrence rateGeneral populationAge-standardised incidence ratesFive-year net survivalAge-standardised incidenceCumulative recurrence ratePopulation-based studyMalignant colorectal polypsTransanal resectionIncidence rateResectionColorectal polypsNet survivalPatientsSurvival analysisSurgeryPolypectomyTime trendsOutcomes
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