2025
Dual Prompting for Diverse Count-Level Pet Denoising
Liu X, Huang Y, Marin T, Chemli Y, Eslahi S, Tiss A, Johnson K, Fakhri G, Ouyang J. Dual Prompting for Diverse Count-Level Pet Denoising. 2025, 00: 1-5. DOI: 10.1109/isbi60581.2025.10980695.Peer-Reviewed Original Research
2024
PDM: A Plug-and-Play Perturbed Multi-path Diffusion Module for Simultaneous Medical Image Segmentation Improvement and Uncertainty Estimation
Zhou B, Chen T, Hou J, Zhou Y, Xie H, Liu C, Duncan J. PDM: A Plug-and-Play Perturbed Multi-path Diffusion Module for Simultaneous Medical Image Segmentation Improvement and Uncertainty Estimation. Lecture Notes In Computer Science 2024, 15241: 259-268. DOI: 10.1007/978-3-031-73284-3_26.Peer-Reviewed Original ResearchEfficient plug-and-play moduleDenoising diffusion probabilistic modelPlug-and-play moduleDiffusion probabilistic modelState-of-the-artMedical image analysisDeep modelsSegmentation datasetUncertainty estimationSegmentation resultsImproved segmentationSegmentation modelMorphological operationsBinary segmentationSegmentation improvementProbabilistic modelUncertainty mapsDiffusion moduleReverse pathPerturbation segmentsSegmental inputsImage analysisSegmentsInputModulation
2023
VIP interneurons regulate cortical size tuning and visual perception
Ferguson K, Salameh J, Alba C, Selwyn H, Barnes C, Lohani S, Cardin J. VIP interneurons regulate cortical size tuning and visual perception. Cell Reports 2023, 42: 113088. PMID: 37682710, PMCID: PMC10618959, DOI: 10.1016/j.celrep.2023.113088.Peer-Reviewed Original ResearchConceptsState-dependent modulationPyramidal neuronsVIP-INsBehavioral state-dependent modulationCortical circuit functionVasoactive intestinal peptidePrimary visual cortexAwake behaving miceIntestinal peptideGABAergic interneuronsVIP interneuronsCortical activityVisual cortexBehaving miceFeature selectivityInterneuronsSensory processingSpecialized populationCircuit functionStimulus sizeActivity altersDiverse populationsModulationPopulationCortexThe cellular architecture of memory modules in Drosophila supports stochastic input integration
Hafez O, Escribano B, Ziegler R, Hirtz J, Niebur E, Pielage J. The cellular architecture of memory modules in Drosophila supports stochastic input integration. ELife 2023, 12: e77578. PMID: 36916672, PMCID: PMC10069864, DOI: 10.7554/elife.77578.Peer-Reviewed Original ResearchConceptsKenyon cellsDecision moduleEfficient storageComputational principlesMushroom bodiesMB output neuronsPatch-clamp recordingsSpiking behaviorOutput neuronsMemory modulesInput integrationOdor inputSynaptic inputsStochastic connectionsArchitectureSynaptic localizationSynaptic connectionsDecision makingComputational modelInputMemoryNeuronsCellular architectureValenced informationModulation
2021
Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics
Salvan P, Lazari A, Vidaurre D, Mandino F, Johansen-Berg H, Grandjean J. Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics. Cell Reports 2021, 37: 109954. PMID: 34731612, PMCID: PMC8609366, DOI: 10.1016/j.celrep.2021.109954.Peer-Reviewed Original ResearchConceptsBrain-wide dynamicsFrequency-dependent fashionEntorhinal cortex dysfunctionHuman neuroimaging studiesBasic neuronal mechanismsEntorhinal cortex activityExcitatory neuronsTransgenic modelStimulation frequencyCortex activityFMRI fluctuationsNeuronal mechanismsAnatomical circuitsNeuroimaging studiesNeural activityNeuronal spikingCognitive diseasesFMRI analysisDysfunctionModulationDiseaseMiceNeuronsActivityBrainModulation of Neuronal Potassium Channels During Auditory Processing
Wu J, Kaczmarek LK. Modulation of Neuronal Potassium Channels During Auditory Processing. Frontiers In Neuroscience 2021, 15: 596478. PMID: 33613177, PMCID: PMC7887315, DOI: 10.3389/fnins.2021.596478.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPotassium channelsAuditory brainstem neuronsAuditory brainstem nucleiNeuronal potassium channelsAuditory informationBrainstem neuronsBrainstem nucleiCertain neuronsPotassium currentFiring patternsNeuronsGene mutationsAuditory processingAuditory stimuliHigh rateLong-term modulationComplex auditory informationIntrinsic electrical propertiesSuch modulationHuman gene mutationsIntensity of soundAuditory environmentModulation
2019
The manifold structure of limb coordination in walking Drosophila
DeAngelis BD, Zavatone-Veth JA, Clark DA. The manifold structure of limb coordination in walking Drosophila. ELife 2019, 8: e46409. PMID: 31250807, PMCID: PMC6598772, DOI: 10.7554/elife.46409.Peer-Reviewed Original Research
2018
A novel design of electromagnetic levitation system for high-speed maglev train
Long Z, Zhiqiang L, Wang Z, Zhiqiang W, Cheng H, Hu C, Li X, Xiaolong L. A novel design of electromagnetic levitation system for high-speed maglev train. Transportation Systems And Technology 2018, 4: 212-224. DOI: 10.17816/transsyst201843s1212-224.Peer-Reviewed Original ResearchHigh-speed maglev trainElectromagnetic levitation systemMaglev trainHybrid electromagnetLevitation systemLevitation control strategyAdsorption moduleChopper modulationControl strategyEnergy consumptionOver-heatingSystem architectureElectromagnetismDesignSafety protection strategyLevitationModulationChopperExtraction of Auditory Information by Modulation of Neuronal Ion Channels
Kaczmarek L. Extraction of Auditory Information by Modulation of Neuronal Ion Channels. 2018, 273-300. DOI: 10.1093/oxfordhb/9780190849061.013.23.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsTrapezoid bodyMedial nucleusNeuronal firing patternsGroups of neuronsPotassium channel subunitsAuditory neuronsFiring patternsChannel subunitsAuditory informationIon channelsAuditory inputNeuronal ion channelsSuch modulationComplex soundsSpecific patternsNeuronsIncoming stimuliAuditory environmentIdentical neuronsSame patternVariety of responsesSmall numberModulationReviewGroup
2012
Modulation of finger photoplethysmographic traces during forced respiration: Venous blood in motion?
Phillips J, Belhaj A, Shafqat K, Langford R, Shelley K, Kyriacou P. Modulation of finger photoplethysmographic traces during forced respiration: Venous blood in motion? Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2012, 2012: 3644-3647. PMID: 23366717, DOI: 10.1109/embc.2012.6346756.Peer-Reviewed Original ResearchConceptsVenous oxygen saturationOxygen saturationBlood volumeNegative airway pressureAirway pressureVenous bloodArterial saturationRespiratory modulationHealthy volunteersRespiratory frequencyTissue bedsPilot studyResultant modulationArteryModulationFingerBloodPhotoplethysmographic signalsVolunteers
2011
Components of Cross-Frequency Modulation in Health and Disease
Allen EA, Liu J, Kiehl KA, Gelernter J, Pearlson GD, Perrone-Bizzozero NI, Calhoun VD. Components of Cross-Frequency Modulation in Health and Disease. Frontiers In Systems Neuroscience 2011, 5: 59. PMID: 21808609, PMCID: PMC3139214, DOI: 10.3389/fnsys.2011.00059.Peer-Reviewed Original ResearchHealthy controlsSchizophrenia patientsCross-frequency modulationAbnormal temporal integrationDopamine D2 receptorsHigh-frequency activityAuditory oddball taskD2 receptorsCognitive deficitsFunctional connectivityPatientsRisk allelesGenetic polymorphismsΑ2 subunitFronto-temporal electrodesOddball taskEEG recordingsDiseaseReceptorsRisk lociExploratory analysisHealthTotal numberModulationPolymorphism
2008
Cellular Mechanisms Underlying Stimulus-Dependent Gain Modulation in Primary Visual Cortex Neurons In Vivo
Cardin JA, Palmer LA, Contreras D. Cellular Mechanisms Underlying Stimulus-Dependent Gain Modulation in Primary Visual Cortex Neurons In Vivo. Neuron 2008, 59: 150-160. PMID: 18614036, PMCID: PMC2504695, DOI: 10.1016/j.neuron.2008.05.002.Peer-Reviewed Original ResearchConceptsSynaptic activationPrimary visual cortex neuronsCat primary visual cortexVisual cortex neuronsCellular mechanismsPrimary visual cortexNeuronal gainBackground synaptic activityVisual stimuliPostsynaptic effectsCortex neuronsIntracellular recordingsSynaptic activitySynaptic inputsVisual cortexInput resistanceVisual stimulationGain modulationSustained changesVivoSensory contextMembrane potentialNeuronal phenomenaActivationModulation
2004
Summarized Reflections on Metabolism
Shulman R, Rothman D, Schafer J. Summarized Reflections on Metabolism. 2004, 175-184. DOI: 10.1002/0470011505.ch13.Peer-Reviewed Original Research
2001
Three Pairs of Cysteine Residues Mediate Both Redox and Zn2+ Modulation of the NMDA Receptor
Choi Y, Chen H, Lipton S. Three Pairs of Cysteine Residues Mediate Both Redox and Zn2+ Modulation of the NMDA Receptor. Journal Of Neuroscience 2001, 21: 392-400. PMID: 11160420, PMCID: PMC6763802, DOI: 10.1523/jneurosci.21-02-00392.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCells, CulturedCysteineDithiothreitolDose-Response Relationship, DrugDrug SynergismGlycineHistidineMesylatesMutagenesis, Site-DirectedN-MethylaspartateOocytesOxidation-ReductionPatch-Clamp TechniquesReceptors, N-Methyl-D-AspartateStructure-Activity RelationshipSulfhydryl ReagentsTransfectionXenopusZinc
2000
Intrinsic and Extrinsic Modulation of a Single Central Pattern Generating Circuit
Morgan P, Perrins R, Lloyd P, Weiss K. Intrinsic and Extrinsic Modulation of a Single Central Pattern Generating Circuit. Journal Of Neurophysiology 2000, 84: 1186-1193. PMID: 10979994, DOI: 10.1152/jn.2000.84.3.1186.Peer-Reviewed Original ResearchConceptsCerebral peptide 2CBI-2Extrinsic modulationMotor programsAppetitive behaviorApplication of serotoninCentral pattern-generating (CPG) circuitModulatory actionExtrinsic neuromodulationIntrinsic modulationCell neuronsCell activityNeural circuitsAppetitive phasePeptide 2Protraction phaseForm of modulationCentral pattern generatorNeuronsSequential useMCC activityConcomitant disruptionRhythmic behaviorModulationPattern generatorMolecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation
Choi Y, Tenneti L, Le D, Ortiz J, Bai G, Chen H, Lipton S. Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation. Nature Neuroscience 2000, 3: 15-21. PMID: 10607390, DOI: 10.1038/71090.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineChromatography, High Pressure LiquidCysteineDose-Response Relationship, DrugEthyl MethanesulfonateHumansIndicators and ReagentsIon TransportMesylatesMutagenesis, Site-DirectedN-MethylaspartateNitric OxideNitroso CompoundsOocytesPatch-Clamp TechniquesPeptide FragmentsReceptors, N-Methyl-D-AspartateS-NitrosothiolsTransfectionXenopus laevisConceptsS-nitrosylationMolecular basisIon channelsCritical cysteine residuesEndogenous S-nitrosylationSite-directed mutagenesisEndogenous nitric oxideIon channel activityNR2A subunitNitric oxideCysteine residuesSingle cysteineIon channel modulationChannel activityPhysiological conditionsSubunitsChannel modulationCell systemNMDA receptorsMutagenesisCysteineResiduesRegulationAlanineModulationEngineering a Living Cell to Desired Metabolite Concentrations and Fluxes: Pathways with Multifunctional Enzymes
Kholodenko B, Westerhoff H, Schwaber J, Cascante M. Engineering a Living Cell to Desired Metabolite Concentrations and Fluxes: Pathways with Multifunctional Enzymes. Metabolic Engineering 2000, 2: 1-13. PMID: 10935931, DOI: 10.1006/mben.1999.0132.Peer-Reviewed Original ResearchConceptsMultifunctional enzymeRest of metabolismMetabolic engineeringMetabolic control analysisCellular pathwaysCellular metabolismMolecular geneticsCellular enzymesLiving cellsEnzymeMetabolismPathwayGeneticsMachineryMetabolic patternsEnzyme concentrationSingle intermediateModulationCellsMetabolite concentrationsPatterns
1999
Modulation of a pacemaker current through Ca2+-induced stimulation of cAMP production
Lüthi A, McCormick D. Modulation of a pacemaker current through Ca2+-induced stimulation of cAMP production. Nature Neuroscience 1999, 2: 634-641. PMID: 10404196, DOI: 10.1038/10189.Peer-Reviewed Original ResearchConceptsHyperpolarization-activated cation currentIh activationThalamocortical rhythmsThalamocortical activityCation currentNeuronal propertiesPacemaker currentCAMP productionPersistent activationProlonged changesProlonged activationBrief increaseDependent modulationSlow recurrenceActivationSubsequent productionCa2RecurrenceModulationProtein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP–32 and spinophilin
Yan Z, Hsieh–Wilson L, Feng J, Tomizawa K, Allen P, Fienberg A, Nairn A, Greengard P. Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP–32 and spinophilin. Nature Neuroscience 1999, 2: 13-17. PMID: 10195174, DOI: 10.1038/4516.Peer-Reviewed Original ResearchConceptsPP-1Protein phosphatase 1DARPP-32Distinct molecular mechanismsPhosphatase 1Molecular mechanismsAMPA receptor-mediated synaptic transmissionPostsynaptic densityAMPA channelsRegulationSynaptic plasticitySpinophilinNeostriatal neuronsPlasticityPhysiological evidenceGlutamate channelsSynaptic transmissionAMPA receptorsPhosphoproteinProteinMechanismBindingActivityModulationCatalytic activity
1995
Defining control coefficients in non-ideal metabolic pathways
Kholodenko B, Molenaar D, Schuster S, Heinrich R, Westerhoff H. Defining control coefficients in non-ideal metabolic pathways. Biophysical Chemistry 1995, 56: 215-226. PMID: 17023325, DOI: 10.1016/0301-4622(95)00039-z.Peer-Reviewed Original ResearchMetabolic pathwaysFlux control coefficientsHigh enzyme concentrationsMetabolic control analysisBiochemical pathwaysElemental stepsMetabolite channellingMetabolic channellingRelevant pathwaysEnzyme activityPathwayEnzymeControl coefficientsEnzyme concentrationMoiety-conserved cyclesEqual modulationsSpeciesReverse rateElemental processesModulationActivity
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