2024
Weight-loss therapy in patients with obesity with endometrial intraepithelial neoplasia and uterine cancer
Suzuki Y, Chen L, Matsuo K, Ferris J, Elkin E, Melamed A, Kong C, Bickell N, Myers E, Havrilesky L, Xu X, Blank S, Hazelton W, Hershman D, Wright J. Weight-loss therapy in patients with obesity with endometrial intraepithelial neoplasia and uterine cancer. Gynecologic Oncology 2024, 190: 78-83. PMID: 39163750, PMCID: PMC11560631, DOI: 10.1016/j.ygyno.2024.08.003.Peer-Reviewed Original ResearchConceptsEndometrial intraepithelial neoplasiaWeight loss therapyUterine cancerIntraepithelial neoplasiaDiagnosis of uterine cancerDiagnosis of endometrial intraepithelial neoplasiaWeight management medicationsMultivariate logistic regression modelCochran-Armitage testPrimary hysterectomyHormone therapyAdjunctive therapyBariatric surgeryTherapy useMarketScan databasePrimary treatmentLogistic regression modelsNutritional counselingMultivariate regression modelComorbidity scoreRegression modelsTherapyRisk factorsPatientsObesityRisk of new‐onset diabetes and efficacy of pharmacological weight loss therapy
Moura F, Bellavia A, Berg D, Melloni G, Feinberg M, Leiter L, Bohula E, Morrow D, Scirica B, Wiviott S, Sabatine M. Risk of new‐onset diabetes and efficacy of pharmacological weight loss therapy. Diabetes Obesity And Metabolism 2024, 26: 4441-4449. PMID: 39056220, PMCID: PMC11410501, DOI: 10.1111/dom.15798.Peer-Reviewed Original ResearchNew-onset diabetesRisk of new-onset diabetesClinical risk modelWeight loss therapyRisk groupsWeight loss pharmacotherapyMultivariate Cox regressionStable cardiovascular patientsTherapeutic decision makingAbsolute risk reductionHigh-risk groupType 2 diabetesIndependent predictorsValidation cohortFollow-upPersonalized patient careCox regressionHazard ratioPrimary outcomeRisk modelHigh riskInterquartile rangePatientsDiabetesCardiovascular patients
2023
Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial
Grilo C, Lydecker J, Gueorguieva R. Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial. Psychological Medicine 2023, 53: 7775-7784. PMID: 37366017, PMCID: PMC10751383, DOI: 10.1017/s0033291723001800.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderBinge-eating remissionAcute treatmentMaintenance treatmentBinge-eating frequencyDouble-blind placebo-controlled trialBehavioral weight loss therapyWeight lossCo-occurring obesitySuccessful acute treatmentPlacebo-controlled trialWeight loss therapySignificant additional weight lossSingle-site trialAdditional weight lossAcute efficacyRemission rateAdult patientsComorbid obesityBupropionInitial interventionPosttreatment assessmentRespondersPlacebo
2022
Naltrexone-Bupropion and Behavior Therapy, Alone and Combined, for Binge-Eating Disorder: Randomized Double-Blind Placebo-Controlled Trial
Grilo CM, Lydecker JA, Fineberg SK, Moreno JO, Ivezaj V, Gueorguieva R. Naltrexone-Bupropion and Behavior Therapy, Alone and Combined, for Binge-Eating Disorder: Randomized Double-Blind Placebo-Controlled Trial. American Journal Of Psychiatry 2022, 179: 927-937. PMID: 36285406, PMCID: PMC9722598, DOI: 10.1176/appi.ajp.20220267.Peer-Reviewed Original ResearchConceptsBehavioral weight loss therapyBinge-eating disorderPlacebo groupBupropion groupWeight lossRandomized double-blind placebo-controlled trialDouble-blind placebo-controlled trialLogistic regressionBinge-eating remissionPlacebo-controlled trialWeight loss therapyDouble-blind placeboSerious public health problemPublic health problemEvidence-based treatmentsRate of participantsBinge-eating frequencyBinge Eating DisorderMedical comorbiditiesRemission rateLoss therapyPercent weight lossMixed modelsFunctional impairmentSecondary measures
2017
Psychological and Behavioral Treatments for Binge-Eating Disorder.
Grilo CM. Psychological and Behavioral Treatments for Binge-Eating Disorder. The Journal Of Clinical Psychiatry 2017, 78 Suppl 1: 20-24. PMID: 28125175, DOI: 10.4088/jcp.sh16003su1c.04.Peer-Reviewed Original ResearchConceptsBinge-eating disorderBehavioral treatmentBehavioral weight loss therapyCognitive behavioral therapyBinge Eating DisorderBehavioral treatment optionsInterpersonal psychotherapyIntervention protocolBetter outcomesSignificant predictorsWeight lossModest weight lossWeight loss therapyBody shapeReliable predictorTreatment outcomesLoss therapyTreatment optionsDisordersInterventionModeratorPredictorsPsychotherapyPatientsTherapy
2016
Bariatric Surgery Overview of Procedures and Outcomes
Azagury DE, Morton JM. Bariatric Surgery Overview of Procedures and Outcomes. Endocrinology And Metabolism Clinics Of North America 2016, 45: 647-656. PMID: 27519136, DOI: 10.1016/j.ecl.2016.04.013.Peer-Reviewed Original ResearchConceptsBariatric surgeryType 2 diabetic patientsWeight loss therapyMultiple randomized control trialsDiabetes-related mortalityAdvent of laparoscopyRandomized control trialGastric bypassDiabetic patientsLoss therapyObservational studyControl trialMortality ratePatientsSurgeryRemissionBMIDiabetesLaparoscopyBypassTherapyMortalityTrials
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