2025
Utilization of Low‐Dose Phentermine for Weight Loss Prior to Metabolic and Bariatric Surgery: A Prospective, Randomized, and Placebo‐Controlled Trial
Garcia L, Rivas H, Morton J. Utilization of Low‐Dose Phentermine for Weight Loss Prior to Metabolic and Bariatric Surgery: A Prospective, Randomized, and Placebo‐Controlled Trial. Obesity Science & Practice 2025, 11: e70043. PMID: 39830713, PMCID: PMC11739713, DOI: 10.1002/osp4.70043.Peer-Reviewed Original ResearchBody mass indexPreoperative weight lossLow-dose formulationsPlacebo groupWeight lossBariatric surgeryLaparoscopic Roux-en-Y gastric bypassPercentage total weight lossRoux-en-Y gastric bypassPlacebo-controlled trialPreoperative medication useTreatment groupsPost-operative complicationsFollow-up visitImprove weight lossMultivariate regression analysisAverage weight lossSleeve gastrectomyGastric bypassMass indexBariatric patientsTotal weight lossPhenterminePatientsOR time
2020
Sodium glucose cotransporter 2 inhibitors as diuretic adjuvants in acute decompensated heart failure: a case series
Griffin M, Riello R, Rao VS, Ivey-Miranda J, Fleming J, Maulion C, McCallum W, Sarnak M, Collins S, Inzucchi SE, Testani JM. Sodium glucose cotransporter 2 inhibitors as diuretic adjuvants in acute decompensated heart failure: a case series. ESC Heart Failure 2020, 7: 1966-1971. PMID: 32476296, PMCID: PMC7373933, DOI: 10.1002/ehf2.12759.Peer-Reviewed Original ResearchConceptsAcute decompensated heart failureSodium-glucose cotransporter 2 inhibitorsGlucose cotransporter 2 inhibitorsDecompensated heart failureCotransporter 2 inhibitorsType 2 diabetesSGLT-2iBlood pressureHeart failureUrine outputYale-New Haven HospitalWeight lossIncidence of hypokalaemiaSGLT-2i initiationSGLT-2i therapyGlucose-lowering medicationsHeart failure outcomesCohort of patientsAverage weight lossDiuretic dosingDiuretic resistanceAdjunctive therapyWorsened survivalDiuretic efficiencyDiuretic monotherapy
2019
1056 Incorporation of Obesity Management into the Care of Patients With Nonalcoholic Steatohepatitis: The Yale Fatty Liver Disease Model
Mankash M, Kelly M, Dean J, Duffy A, Mehal W, Do A. 1056 Incorporation of Obesity Management into the Care of Patients With Nonalcoholic Steatohepatitis: The Yale Fatty Liver Disease Model. The American Journal Of Gastroenterology 2019, 114: s599-s599. DOI: 10.14309/01.ajg.0000593756.22484.ae.Peer-Reviewed Original ResearchNonalcoholic fatty liver diseaseWeight loss medicationsNonalcoholic steatohepatitisBariatric surgeryWeight lossClinical characteristicsLiver diseaseObesity managementEffective treatmentDisease programsAverage age 55Meal replacement therapySurgical weight lossWeight loss optionsAlanine aminotransferase levelsChronic liver diseaseFatty liver diseaseObstructive sleep apneaManagement of patientsCare of patientsLimited efficacy dataClinical care modelsLiver disease modelAverage weight lossHepatology clinic
2018
Early weight loss predicts weight loss treatment response regardless of binge‐eating disorder status and pretreatment weight change
Barnes RD, Ivezaj V, Pittman BP, Grilo CM. Early weight loss predicts weight loss treatment response regardless of binge‐eating disorder status and pretreatment weight change. International Journal Of Eating Disorders 2018, 51: 558-564. PMID: 29637592, PMCID: PMC6002900, DOI: 10.1002/eat.22860.Peer-Reviewed Original ResearchConceptsEarly weight lossWeight loss treatmentBinge-eating disorderLoss treatmentWeight lossBed statusWeight loss treatment outcomesOverweight/obesityWeight loss trialAverage weight lossWeight-related variablesPrognostic significancePrimary careTreatment outcomesTreatment responseLoss trialWeight trajectoriesTreatment studiesDisorder statusWeight changeOutcomesTreatmentIndividual responsesStatusPositive outcomes
2017
Characteristics of Weight Loss Trajectories in a Comprehensive Lifestyle Intervention
Marek RJ, Coulon SM, Brown JD, Lydecker JA, Marek S, Malcolm R, O'Neil PM. Characteristics of Weight Loss Trajectories in a Comprehensive Lifestyle Intervention. Obesity 2017, 25: 2062-2067. PMID: 29086487, DOI: 10.1002/oby.21942.Peer-Reviewed Original ResearchConceptsWeight loss trajectoriesAverage weight lossWeight lossLifestyle interventionWeight changeWeight gainComprehensive lifestyle interventionLatent class analysisMeal replacement dietMore tailored interventionsLifestyle change counselingWeekly weight changesWeekly weight gainPercent weight lossLess optimal outcomesLifestyle programEfficacy dataGroup 2Group 1Group 3Class analysisPatientsTailored interventionsOptimal outcomesPercent weight gainAcoustic speech analysis of patients with decompensated heart failure: A pilot study
Murton O, Daher M, Cunningham T, Verkouw K, Tabtabai S, Steiner J, Hillman R, Dec G, Ausiello D, Mehta D. Acoustic speech analysis of patients with decompensated heart failure: A pilot study. The Journal Of The Acoustical Society Of America 2017, 142: 2639-2640. DOI: 10.1121/1.5014673.Peer-Reviewed Original ResearchHeart failureIntracardiac filling pressuresDecompensated heart failureImpaired cardiac functionMean length of stayAverage weight lossLength of stayPeripheral edemaCardiac functionPrevent decompensationFilling pressurePatientsDecompensationMonitoring PatientsEdemaWeight lossMean lengthInpatient treatmentEarly indicatorPilot studyChronic conditionsAcoustic speech analysisTreatmentMental health and behavioral weight loss: 24-month outcomes in Veterans
Janney CA, Masheb RM, Lutes LD, Holleman RG, Kim HM, Gillon LR, Damschroder LJ, Richardson CR. Mental health and behavioral weight loss: 24-month outcomes in Veterans. Journal Of Affective Disorders 2017, 215: 197-204. PMID: 28340446, DOI: 10.1016/j.jad.2017.03.003.Peer-Reviewed Original ResearchConceptsBehavioral weight loss interventionSerious mental illnessWeight loss interventionMH diagnosisLoss interventionAffective disordersWeight lossModest weight lossOverweight/obeseBehavioral weight lossWeight loss trialMental health disordersAverage weight lossWeight loss differencesSecondary data analysisLoss trialThree-armHealth disordersWeight loss patternsLinear mixed effects modelsMental illnessDiagnostic groupsDiagnosisMental healthMonths
2012
Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes
Petersen KF, Dufour S, Morino K, Yoo PS, Cline GW, Shulman GI. Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 8236-8240. PMID: 22547801, PMCID: PMC3361376, DOI: 10.1073/pnas.1205675109.Peer-Reviewed Original ResearchConceptsMuscle insulin resistanceInsulin-resistant offspringType 2 diabetesBranched-chain amino acidsInsulin resistanceIR offspringInsulin-stimulated muscle glucose uptakeWeight lossPeripheral insulin responsivenessReduction of IMCLModest weight lossPeripheral glucose metabolismC-reactive proteinHyperinsulinemic-euglycemic clampIntramyocellular lipid accumulationMuscle glucose uptakeAverage weight lossWeight reductionTotal adiponectinHypocaloric dietIL-6IMCL contentPlasma concentrationsWeight stabilizationIMCL accumulation
2010
Testing a new cognitive behavioural treatment for obesity: A randomized controlled trial with three-year follow-up
Cooper Z, Doll HA, Hawker DM, Byrne S, Bonner G, Eeley E, O’Connor M, Fairburn CG. Testing a new cognitive behavioural treatment for obesity: A randomized controlled trial with three-year follow-up. Behaviour Research And Therapy 2010, 48: 706-713. PMID: 20691328, PMCID: PMC2923743, DOI: 10.1016/j.brat.2010.03.008.Peer-Reviewed Original ResearchConceptsNew cognitive behavioural treatmentCognitive-behavioral treatmentBehavioral treatmentPsychological treatmentPsychological methodsBehavior therapyLong-term effectsFemale participantsWeight regainWeight lossNew treatmentsParticipantsFurther supportAverage weight lossObesityPresent studyMain treatmentTreatmentThree yearsShort-term perspectiveAbsence of dataPeopleFindingsSupportGreat majority
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