2023
Autophagy markers, cognitive deficits and depressive symptoms in Parkinson’s disease
Li Y, Yang H, Zhao P, Yang J, Yao C, Zhou C, Yang C, Sun X, Li S, Li J. Autophagy markers, cognitive deficits and depressive symptoms in Parkinson’s disease. Journal Of Neural Transmission 2023, 131: 73-81. PMID: 37801108, DOI: 10.1007/s00702-023-02702-w.Peer-Reviewed Original ResearchConceptsDepressed PD patientsDepressive symptomsNaming abilityPD patientsHamilton Depression Rating Scale-17Cognitive impairmentNon-depressed PD patientsLC3-II/LC3-IAssociated with delayed recallParkinson's diseaseAssociated with cognitive functionAssociated with MoCA scoresHAMD-17Cognitive deficitsMontreal Cognitive AssessmentDelayed RecallCognitive functionCognitive AssessmentGlycolipid parametersAutophagy markersMoCA scoresSymptomsMotor functionImpairmentRecall
2018
d-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer
Yu X, Lin H, Wang Y, Lv W, Zhang S, Qian Y, Deng X, Feng N, Yu H, Qian B. d-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer. OncoTargets And Therapy 2018, 11: 1833-1847. PMID: 29670359, PMCID: PMC5894671, DOI: 10.2147/ott.s155716.Peer-Reviewed Original ResearchLung cancer cellsLung cancerCancer cellsTherapeutic effectUse of chloroquineXenograft animal modelCell Counting Kit-8Real-time quantitative polymerase chain reactionCounting Kit-8Flow cytometric analysisQuantitative polymerase chain reactionMechanism of actionExpression of apoptosisPolymerase chain reactionApoptosis-related gene expressionAnimal modelsNude miceCytometric analysisKit-8Western blotAutophagy markersAutophagy inhibitorCancerAntitumor activityProapoptotic effects
2015
Autophagy Alleviates Melamine-Induced Cell Death in PC12 Cells Via Decreasing ROS Level
Wang H, Gao N, Li Z, Yang Z, Zhang T. Autophagy Alleviates Melamine-Induced Cell Death in PC12 Cells Via Decreasing ROS Level. Molecular Neurobiology 2015, 53: 1718-1729. PMID: 25724280, DOI: 10.1007/s12035-014-9073-2.Peer-Reviewed Original ResearchConceptsPC12 cellsLC3-II/LC3Western blot assaysCell deathReactive oxygen species levelsSuperoxide dismutase activityMDA levelsOxygen species levelsGeneration of ROSATG-7Autophagy markersBlot assaysIncrease of autophagosomesBeclin-1Oxidative stressDismutase activityROS levelsRapamycinExcessive generationExpression levelsCell viabilityOxidative damageAutophagyMalondialdehydeDeath
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